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Gene Review

smd-1  -  Protein SMD-1

Caenorhabditis elegans

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Disease relevance of smd-1

  • The best inhibitor, BW-1, was about 10-fold more effective against O. volvulus AdoMetDC than against the human enzyme [1].

High impact information on smd-1


Chemical compound and disease context of smd-1


Associations of smd-1 with chemical compounds

  • In conclusion, a similar minimal promoter architecture was found for C. elegans as well as C. briggsae AdoMetDC and spermidine synthase, two genes that participate in the same metabolic pathway [3].
  • S-Adenosylmethionine decarboxylase (AdoMetDC) is a key enzyme in polyamine biosynthesis [1].

Analytical, diagnostic and therapeutic context of smd-1

  • S-Adenosylmethionine decarboxylase (SAMDC) is a major regulatory enzyme in the polyamine biosynthesis and is considered a potentially important drug target for the chemotherapy of proliferative and parasitic diseases [2].
  • Furthermore, site-directed mutagenesis revealed that at least Glu33, Ser83, Arg91 and Lys95 are involved in posttranslational processing of C. elegans AdoMetDC [4].


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