The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

prdx-3  -  Protein PRDX-3

Caenorhabditis elegans

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of prdx-3


High impact information on prdx-3

  • The G. rostochiensis peroxiredoxin catalyses the breakdown of hydrogen peroxide, but not cumene or t-butyl hydroperoxide, in a trypanosomatid reducing system comprising trypanothione reductase, trypanothione and tryparedoxin [2].
  • The protein encoded by nDiTPx had a predicted molecular mass of 22.1 kDa and the deduced amino acid sequence was homologous to thioredoxin peroxidase-like sequences described in other filarial nematodes, yeast, bacteria and mammals [3].
  • A Dirofilaria immitis cDNA clone encoding a nucleic acid homolog of thioredoxin peroxidase (nDiTPx) was isolated from a fourth-stage larval cDNA library, using serum from dogs vaccinated by chemotherapeutically-abbreviated D. immitis larval infections [3].

Analytical, diagnostic and therapeutic context of prdx-3


  1. Removal of hydrogen peroxide by a 1-cysteine peroxiredoxin enzyme of the filarial parasite Dirofilaria immitis. Chandrashekar, R., Tsuji, N., Morales, T.H., Carmody, A.B., Ozols, V.O., Welton, J., Tang, L. Parasitol. Res. (2000) [Pubmed]
  2. Cloning, expression and functional characterisation of a peroxiredoxin from the potato cyst nematode Globodera rostochiensis. Robertson, L., Robertson, W.M., Sobczak, M., Helder, J., Tetaud, E., Ariyanayagam, M.R., Ferguson, M.A., Fairlamb, A., Jones, J.T. Mol. Biochem. Parasitol. (2000) [Pubmed]
  3. Molecular cloning, expression and enzymatic activity of a thioredoxin peroxidase from Dirofilaria immitis. Klimowski, L., Chandrashekar, R., Tripp, C.A. Mol. Biochem. Parasitol. (1997) [Pubmed]
WikiGenes - Universities