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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Prdx3  -  peroxiredoxin 3

Rattus norvegicus

Synonyms: PRX-3, PRx III, Peroxiredoxin-3, Thioredoxin-dependent peroxide reductase, mitochondrial
 
 
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Disease relevance of Prdx3

  • Furthermore, in vivo adenoviral gene transfer of Prx-3 completely inhibited protein nitration and markedly reduced gliosis, a post-neuronal cell death event [1].
  • Since mitochondrial Prx-3 seems to be neuroprotective against oxidative insults, our findings suggest that Prx-3 up-regulation might be a useful novel approach for the management of neurodegenerative diseases [1].
 

High impact information on Prdx3

  • In the present study, we focused on a mitochondrial antioxidant protein, peroxiredoxin-3 (Prx-3), to investigate the mechanism by which toxic properties of ROS were up-regulated in mitochondria of damaged nerve cells [1].
  • Immunohistochemical analysis revealed that Prx-3 protein exists in mitochondria of rat hippocampus, whereas we found a significant decrease in Prx-3 mRNA and protein levels associated with an increase in nitrated proteins in the rat hippocampus injured by microinjection of ibotenic acid [1].
  • Malate dehydrogenase, peroxiredoxin 3, vacuolar ATP synthase subunit beta and mitogen-activated protein kinase kinase 1 were found to have altered expression levels in the groups treated with antipsychotics compared with the matched controls [2].

References

  1. Mitochondrial peroxiredoxin-3 protects hippocampal neurons from excitotoxic injury in vivo. Hattori, F., Murayama, N., Noshita, T., Oikawa, S. J. Neurochem. (2003) [Pubmed]
  2. Hippocampus protein profiling reveals aberration of malate dehydrogenase in chlorpromazine/clozapine treated rats. La, Y., Wan, C., Zhu, H., Yang, Y., Chen, Y., Pan, Y., Ji, B., Feng, G., He, L. Neurosci. Lett. (2006) [Pubmed]
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