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Gene Review

Naip5  -  NLR family, apoptosis inhibitory protein 5

Mus musculus

Synonyms: Birc1e, Lgn1, Naip-rs3
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Disease relevance of Naip5


Psychiatry related information on Naip5


High impact information on Naip5


Biological context of Naip5

  • These results suggest that sensing of L. pneumophila products by Birc1e/Naip5 in macrophages occurs rapidly following phagocytosis, a process that antagonizes the ability of L. pneumophila to remodel its phagosome into a specialized vacuole with ER characteristics [5].
  • We speculate that Naip5 is a functional mammalian homolog of plant "resistance" proteins that monitor for, and initiate host response to, the presence of secreted bacterial virulence proteins [3].

Anatomical context of Naip5


Other interactions of Naip5


  1. Birc1e is the gene within the Lgn1 locus associated with resistance to Legionella pneumophila. Diez, E., Lee, S.H., Gauthier, S., Yaraghi, Z., Tremblay, M., Vidal, S., Gros, P. Nat. Genet. (2003) [Pubmed]
  2. The Birc1e cytosolic pattern-recognition receptor contributes to the detection and control of Legionella pneumophila infection. Zamboni, D.S., Kobayashi, K.S., Kohlsdorf, T., Ogura, Y., Long, E.M., Vance, R.E., Kuida, K., Mariathasan, S., Dixit, V.M., Flavell, R.A., Dietrich, W.F., Roy, C.R. Nat. Immunol. (2006) [Pubmed]
  3. Naip5 affects host susceptibility to the intracellular pathogen Legionella pneumophila. Wright, E.K., Goodart, S.A., Growney, J.D., Hadinoto, V., Endrizzi, M.G., Long, E.M., Sadigh, K., Abney, A.L., Bernstein-Hanley, I., Dietrich, W.F. Curr. Biol. (2003) [Pubmed]
  4. High-resolution genetic and physical map of the Lgn1 interval in C57BL/6J implicates Naip2 or Naip5 in Legionella pneumophila pathogenesis. Growney, J.D., Dietrich, W.F. Genome Res. (2000) [Pubmed]
  5. Birc1e/Naip5 rapidly antagonizes modulation of phagosome maturation by Legionella pneumophila. Fortier, A., de Chastellier, C., Balor, S., Gros, P. Cell. Microbiol. (2007) [Pubmed]
  6. Interferon-Gamma Reverses the Evasion of Birc1e/Naip5 Gene Mediated Murine Macrophage Immunity by Legionella pneumophila Mutant Lacking Flagellin. Akamine, M., Higa, F., Haranaga, S., Tateyama, M., Mori, N., Heuner, K., Fujita, J. Microbiol. Immunol. (2007) [Pubmed]
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