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Gene Review:

Naip5 - NLR family, apoptosis inhibitory protein 5

Mus musculus

Synonyms: Birc1e, Lgn1, Naip-rs3

Wright, E.K. et al., Zamboni, D.S. et al., Fortier, A. et al., Akamine, M. et al., Growney, J.D. et al., et al.

Akamine, Higa, Haranaga, Tateyama, Mori, Heuner, Fujita,

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Disease relevance of Naip5

Birc1e is the gene within the Lgn1 locus associated with resistance to Legionella pneumophila [1].
Caspase-1 was required for Birc1e-dependent antibacterial responses ex vivo in macrophages and in a mouse model of Legionnaires' disease [2].

Psychiatry related information on Naip5

Detailed recombination mapping and analysis of expression implicates Naip5 in the Legionella permissiveness differences among mouse strains [3].

High impact information on Naip5

Here we describe a Birc1e-dependent signaling pathway that restricted replication of the intracellular pathogen Legionella pneumophila in mouse macrophages [2].
Translocation of bacterial products into host-cell cytosol was essential for Birc1e-mediated control of bacterial replication [2].
High-resolution genetic and physical map of the Lgn1 interval in C57BL/6J implicates Naip2 or Naip5 in Legionella pneumophila pathogenesis [4].
Naip5 encodes a protein that is homologous to plant innate immunity (so-called "resistance") proteins and has been implicated in signaling pathways related to apoptosis regulation [3].
A bacterial artificial chromosome (BAC) transgenic line expressing a nonpermissive allele of Naip5 exhibits a reduction in macrophage Legionella permissiveness [3].

Biological context of Naip5

These results suggest that sensing of L. pneumophila products by Birc1e/Naip5 in macrophages occurs rapidly following phagocytosis, a process that antagonizes the ability of L. pneumophila to remodel its phagosome into a specialized vacuole with ER characteristics [5].
We speculate that Naip5 is a functional mammalian homolog of plant "resistance" proteins that monitor for, and initiate host response to, the presence of secreted bacterial virulence proteins [3].

Anatomical context of Naip5

Birc1e/Naip5 rapidly antagonizes modulation of phagosome maturation by Legionella pneumophila [5].

Other interactions of Naip5

Interferon-Gamma Reverses the Evasion of Birc1e/Naip5 Gene Mediated Murine Macrophage Immunity by Legionella pneumophila Mutant Lacking Flagellin [6].

References

Birc1e is the gene within the Lgn1 locus associated with resistance to Legionella pneumophila. Diez, E., Lee, S.H., Gauthier, S., Yaraghi, Z., Tremblay, M., Vidal, S., Gros, P. Nat. Genet. (2003) [Pubmed]
The Birc1e cytosolic pattern-recognition receptor contributes to the detection and control of Legionella pneumophila infection. Zamboni, D.S., Kobayashi, K.S., Kohlsdorf, T., Ogura, Y., Long, E.M., Vance, R.E., Kuida, K., Mariathasan, S., Dixit, V.M., Flavell, R.A., Dietrich, W.F., Roy, C.R. Nat. Immunol. (2006) [Pubmed]
Naip5 affects host susceptibility to the intracellular pathogen Legionella pneumophila. Wright, E.K., Goodart, S.A., Growney, J.D., Hadinoto, V., Endrizzi, M.G., Long, E.M., Sadigh, K., Abney, A.L., Bernstein-Hanley, I., Dietrich, W.F. Curr. Biol. (2003) [Pubmed]
High-resolution genetic and physical map of the Lgn1 interval in C57BL/6J implicates Naip2 or Naip5 in Legionella pneumophila pathogenesis. Growney, J.D., Dietrich, W.F. Genome Res. (2000) [Pubmed]
Birc1e/Naip5 rapidly antagonizes modulation of phagosome maturation by Legionella pneumophila. Fortier, A., de Chastellier, C., Balor, S., Gros, P. Cell. Microbiol. (2007) [Pubmed]
Interferon-Gamma Reverses the Evasion of Birc1e/Naip5 Gene Mediated Murine Macrophage Immunity by Legionella pneumophila Mutant Lacking Flagellin. Akamine, M., Higa, F., Haranaga, S., Tateyama, M., Mori, N., Heuner, K., Fujita, J. Microbiol. Immunol. (2007) [Pubmed]

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Naip1	Mus musculus
Naip6	Mus musculus
Naip5	Rattus norvegicus
Naip6	Rattus norvegicus

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