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MeSH Review

Legionnaires' Disease

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Disease relevance of Legionnaires' Disease


High impact information on Legionnaires' Disease


Chemical compound and disease context of Legionnaires' Disease


Biological context of Legionnaires' Disease


Anatomical context of Legionnaires' Disease

  • The lack of reactivity with negative control sera and strong reactivity from a small group of patients in whom seroconversion was demonstrated has led us to conclude that formolised yolk-sac antigen is a reliable antigen for the diagnosis of Legionnaires' disease by the FA method [19].
  • The standard selective Legionella medium that contains cefamandole failed to grow legionella pneumophila serogroup 1, subtype Bellingham, from a sputum sample from a patient with nosocomial Legionnaires' disease; the isolate did grow on a similar selective medium that substitutes vancomycin for cefamandole [20].

Gene context of Legionnaires' Disease


Analytical, diagnostic and therapeutic context of Legionnaires' Disease


  1. Intracellular multiplication of Legionnaires' disease bacteria (Legionella pneumophila) in human monocytes is reversibly inhibited by erythromycin and rifampin. Horwitz, M.A., Silverstein, S.C. J. Clin. Invest. (1983) [Pubmed]
  2. Legionnaires' disease in patients with associated serious disease. Gump, D.W., Frank, R.O., Winn, W.C., Foster, R.S., Broome, C.V., Cherry, W.B. Ann. Intern. Med. (1979) [Pubmed]
  3. Sporadic cases of Legionnaires' disease in Great Britain. Bartlett, C.L. Ann. Intern. Med. (1979) [Pubmed]
  4. Pulmonary function after adult respiratory distress syndrome associated with Legionnaires' disease pneumonia. Shaw, R.A., Whitcomb, M.E., Schonfeld, S.A. Arch. Intern. Med. (1981) [Pubmed]
  5. Legionnaires' disease: antigenic peculiarities, strain differences, and antibiotic sensitivities of the agent. Ormsbee, R.A., Peacock, M.G., Lattimer, G.L., Page, L.A., Fiset, P. J. Infect. Dis. (1978) [Pubmed]
  6. Legionnaires' disease: concentrations of selenium and other elements. Chen, J.R., Anderson, J.M. Science (1979) [Pubmed]
  7. Major cytoplasmic membrane protein of Legionella pneumophila, a genus common antigen and member of the hsp 60 family of heat shock proteins, induces protective immunity in a guinea pig model of Legionnaires' disease. Blander, S.J., Horwitz, M.A. J. Clin. Invest. (1993) [Pubmed]
  8. Outbreak of Legionnaires' disease among cruise ship passengers exposed to a contaminated whirlpool spa. Jernigan, D.B., Hofmann, J., Cetron, M.S., Genese, C.A., Nuorti, J.P., Fields, B.S., Benson, R.F., Carter, R.J., Edelstein, P.H., Guerrero, I.C., Paul, S.M., Lipman, H.B., Breiman, R. Lancet (1996) [Pubmed]
  9. Treatment of experimental Legionnaires' disease by aerosol administration of rifampicin, ciprofloxacin, and erythromycin. Fitzgeorge, R.B., Baskerville, A., Featherstone, A.S. Lancet (1986) [Pubmed]
  10. Imipenem in Legionnaires' disease. Edelstein, P.H. Lancet (1984) [Pubmed]
  11. Legionnaires' disease treated with doxycycline. Cunha, B.A., Jonas, M. Lancet (1981) [Pubmed]
  12. Minocycline in legionnaires' disease. Nash, P., Sideman, L., Pidcoe, V., Kleger, B. Lancet (1978) [Pubmed]
  13. Fine structure of the Legionnaires' disease bacterium. In-vitro and in-vivo studies of four isolates. Keel, J.A., Finnerty, W.R., Feeley, J.C. Ann. Intern. Med. (1979) [Pubmed]
  14. Summertime pneumonias in Philadelphia in 1976. An epidemiologic study. Sharrar, R.G., Friedman, H.M., Miller, W.T., Yanak, M.J., Abrutyn, E. Ann. Intern. Med. (1979) [Pubmed]
  15. Legionella pneumophila entry gene rtxA is involved in virulence. Cirillo, S.L., Bermudez, L.E., El-Etr, S.H., Duhamel, G.E., Cirillo, J.D. Infect. Immun. (2001) [Pubmed]
  16. Identification of a novel adhesion molecule involved in the virulence of Legionella pneumophila. Chang, B., Kura, F., Amemura-Maekawa, J., Koizumi, N., Watanabe, H. Infect. Immun. (2005) [Pubmed]
  17. Legionella: macrolides or quinolones? Pedro-Botet, L., Yu, V.L. Clin. Microbiol. Infect. (2006) [Pubmed]
  18. Cellular immunity in typhoid fever, Legionnaires' disease, amebiasis: role of transfer factor and Levamisole in typhoid fever. Tanphaichitra, D. Dev. Biol. Stand. (1983) [Pubmed]
  19. False positive reactions in the indirect fluorescent antibody test for Legionnaires' disease eliminated by use of formolised yolk-sac antigen. Taylor, A.G., Harrison, T.G., Dighero, M.W., Bradstreet, C.M. Ann. Intern. Med. (1979) [Pubmed]
  20. Cefamandole-susceptible strains of Legionella pneumophila serogroup 1: implications for diagnosis and utility as an epidemiological marker. Vickers, R.M., Stout, J.E., Tompkins, L.S., Troup, N.J., Yu, V.L. J. Clin. Microbiol. (1992) [Pubmed]
  21. Immunomodulatory role of endogenous interleukin-18 in gamma interferon-mediated resolution of replicative Legionella pneumophila lung infection. Brieland, J.K., Jackson, C., Hurst, S., Loebenberg, D., Muchamuel, T., Debets, R., Kastelein, R., Churakova, T., Abrams, J., Hare, R., O'Garra, A. Infect. Immun. (2000) [Pubmed]
  22. Prevalence of antibodies to Legionnaires' disease. A seroepidemiologic survey of Michigan residents using the hemagglutination test. Edson, D.C., Stiefel, H.E., Wentworth, B.B., Wilson, D.L. Ann. Intern. Med. (1979) [Pubmed]
  23. Crystal structure of Mip, a prolylisomerase from Legionella pneumophila. Riboldi-Tunnicliffe, A., König, B., Jessen, S., Weiss, M.S., Rahfeld, J., Hacker, J., Fischer, G., Hilgenfeld, R. Nat. Struct. Biol. (2001) [Pubmed]
  24. Legionnaires' disease in a patient with systemic lupus erythematosus. Jacox, R.F., Stuard, I.D. Arthritis Rheum. (1978) [Pubmed]
  25. Antibiotic treatment of guinea-pigs infected with agent of Legionnaires' disease. Fraser, D.W., Wachsmuth, I., Bopp, C., Feeley, J.C., Tsai, T.F. Lancet (1978) [Pubmed]
  26. Fatal Legionnaires' disease coincident with initiation of immunosuppressive therapy. Sheldon, P.A., Tight, R.R., Renner, E.D. Arch. Intern. Med. (1985) [Pubmed]
  27. Activities of tigecycline (GAR-936) against Legionella pneumophila in vitro and in guinea pigs with L. pneumophila pneumonia. Edelstein, P.H., Weiss, W.J., Edelstein, M.A. Antimicrob. Agents Chemother. (2003) [Pubmed]
  28. Intravenous azithromycin as salvage therapy in a patient with Legionnaire's disease. Dorrell, L., Fulton, B., Ong, E.L. Thorax (1994) [Pubmed]
  29. Erythromycin prophylaxis for Legionnaire's disease in immunosuppressed patients in a contaminated hospital environment. Vereerstraeten, P., Stolear, J.C., Schoutens-Serruys, E., Maes, N., Thys, J.P., Liesnard, C., Rost, F., Kinnaert, P., Toussaint, C. Transplantation (1986) [Pubmed]
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