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Gene Review

Nptx1  -  neuronal pentraxin 1

Mus musculus

Synonyms: D11Bwg1004e, NP-I, NP1, Neuronal pentraxin I, Neuronal pentraxin-1, ...
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Disease relevance of Nptx1

  • A dose-dependent decrease was observed in terminal body weights of males of the F1 generation; however, a very small negative effect was only found in the females of the NP1/10 group [1].

High impact information on Nptx1

  • Here, we report human cDNA and mouse genomic DNA sequences for NP1 (gene symbol NPTX1) [2].
  • The human and mouse NP1 genes are localized to chromosome 17q25.1-q25.2 and chromosome 11e2-e1.3, respectively [2].
  • Human NP1 and mouse NP1 show 95 and 99% amino acid identity, respectively, with rat NP1 and conserve all potential glycosylation sites [2].
  • In addition to monoclonal immunoglobulin, two kinds of nucleoproteins, NP1 and NP2, were isolated from the supernatants of hybridoma cultures set up in a protein-free medium [3].
  • The weights of the testis and epididymis were slightly decreased in the NP1/10 group [1].

Biological context of Nptx1

  • In addition, a specific subset of NP-1-negative and olfactory cell adhesion molecule-positive glomeruli, especially those in the anteromedial region, disappeared from the mutant OB [4].

Anatomical context of Nptx1

  • However, the overall mortality of fetuses/embryos was increased considerably in the NP1/100 (male: 13.9%) and NP1/10 (female: 9.8%) groups [1].

Analytical, diagnostic and therapeutic context of Nptx1

  • Based upon an N. caninum-specific DNA fragment that we have recently cloned, 5 sense (Np1, Np3, Np5, Np7, Np21) and 4 antisense (Np2, Np4, Np6, Np8) oligonucleotides were designed for a sensitive and specific polymerase chain reaction (PCR) [5].


  1. Effect of gestational exposure to nonylphenol on the development and fertility of mouse offspring. Kimura, N., Kimura, T., Suzuki, M., Totsukawa, K. J. Reprod. Dev. (2006) [Pubmed]
  2. Mouse and human neuronal pentraxin 1 (NPTX1): conservation, genomic structure, and chromosomal localization. Omeis, I.A., Hsu, Y.C., Perin, M.S. Genomics (1996) [Pubmed]
  3. Nucleosomes occurring in protein-free hybridoma cell culture. Evidence for programmed cell death. Franĕk, F., Dolníková, J. FEBS Lett. (1991) [Pubmed]
  4. Distorted odor maps in the olfactory bulb of semaphorin 3A-deficient mice. Taniguchi, M., Nagao, H., Takahashi, Y.K., Yamaguchi, M., Mitsui, S., Yagi, T., Mori, K., Shimizu, T. J. Neurosci. (2003) [Pubmed]
  5. Neospora caninum: specific oligonucleotide primers for the detection of brain "cyst" DNA of experimentally infected nude mice by the polymerase chain reaction (PCR). Yamage, M., Flechtner, O., Gottstein, B. J. Parasitol. (1996) [Pubmed]
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