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Gene Review

EPYC  -  epiphycan

Homo sapiens

Synonyms: DSPG3, Dermatan sulfate proteoglycan 3, Epiphycan, PG-Lb, PGLB, ...
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High impact information on EPYC

  • There are 14 potential binding sites for SOX9, a transcription factor present in cartilage, in the promoter, and in the first intron of DSPG3 [1].
  • In this study, we have determined that the human DSPG3 gene is composed of seven exons: Exon 2 of DSPG3 includes the start codon, exons 4-7 code for the leucine-rich repeats, exons 3 and 7 contain the potential glycosaminoglycan attachment sites, and exon 7 contains the potential N-glycosylation sites and the stop codon [1].
  • In contrast to the tissue distribution of the other SLRPs, DSPG3 is predominantly expressed in cartilage [1].
  • Analysis of 1.6 kb of upstream promoter sequence of DSPG3 reveals three TATA boxes, one of which is 20 nucleotides before the transcription start site [1].
  • After Sepharose CL-4B chromatography, newly synthesized scleral proteoglycans isolated from normal, form-deprived, and contralateral control eyes, resolved into one major peak that eluted in the position of decorin, a small chondroitin-dermatan sulfate proteoglycan [2].

Biological context of EPYC


Anatomical context of EPYC

  • In the developing limb, chick PG-Lb appears to be exclusively expressed in the zone of flattened chondrocytes [3].
  • Thus in these respects they were unlike the small proteochondroitins (PG-Lb or PG-Lt) that have been found in chick-embryo cartilage [4].

Associations of EPYC with chemical compounds

  • Characterization of human DSPG3, a small dermatan sulfate proteoglycan [3].

Other interactions of EPYC


  1. Genomic characterization of human DSPG3. Deere, M., Dieguez, J.L., Yoon, S.J., Hewett-Emmett, D., de la Chapelle, A., Hecht, J.T. Genome Res. (1999) [Pubmed]
  2. Decreased proteoglycan synthesis associated with form deprivation myopia in mature primate eyes. Rada, J.A., Nickla, D.L., Troilo, D. Invest. Ophthalmol. Vis. Sci. (2000) [Pubmed]
  3. Characterization of human DSPG3, a small dermatan sulfate proteoglycan. Deere, M., Johnson, J., Garza, S., Harrison, W.R., Yoon, S.J., Elder, F.F., Kucherlapati, R., Hook, M., Hecht, J.T. Genomics (1996) [Pubmed]
  4. Formation of two species of nascent proteochondroitin in separate loci of a microsomal preparation from chick-embryo epiphyseal cartilage. Sugumaran, G., Silbert, J.E. Biochem. J. (1991) [Pubmed]
  5. Cloning and characterization of opticin cDNA: evaluation as a candidate for canine oculo-skeletal dysplasia. Pellegrini, B., Acland, G.M., Ray, J. Gene (2002) [Pubmed]
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