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Gene Review

Epyc  -  epiphycan

Mus musculus

Synonyms: Dermatan sulfate proteoglycan 3, Dspg3, Epiphycan, PG-Lb, Pglb, ...
 
 
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Disease relevance of Epyc

  • One of these monoclonal antibodies (IgM; designated MO-225) reacts with PG-M, chick embryo cartilage proteoglycans (PG-H, PG-Lb, and PG-Lt), and bovine nasal cartilage proteoglycan, but not with Swarm rat chondrosarcoma proteoglycan [1].
 

High impact information on Epyc

 

Biological context of Epyc

 

Anatomical context of Epyc

 

Analytical, diagnostic and therapeutic context of Epyc

  • Reverse transcriptase PCR using degenerate oligonucleotide primers gave a cDNA fragment that might correspond to mouse PG-Lb [3].

References

  1. A monoclonal antibody that specifically recognizes a glucuronic acid 2-sulfate-containing determinant in intact chondroitin sulfate chain. Yamagata, M., Kimata, K., Oike, Y., Tani, K., Maeda, N., Yoshida, K., Shimomura, Y., Yoneda, M., Suzuki, S. J. Biol. Chem. (1987) [Pubmed]
  2. The gene structure and organization of mouse PG-Lb, a small chondroitin/dermatan sulphate proteoglycan. Iwata, Y., Shinomura, T., Kurita, K., Zako, M., Kimata, K. Biochem. J. (1998) [Pubmed]
  3. Occurrence of PG-Lb, a leucine-rich small chondroitin/dermatan sulphate proteoglycan in mammalian epiphyseal cartilage: molecular cloning and sequence analysis of the mouse cDNA. Kurita, K., Shinomura, T., Ujita, M., Zako, M., Kida, D., Iwata, H., Kimata, K. Biochem. J. (1996) [Pubmed]
  4. Decorin, epiphycan, and lumican genes are closely linked on murine Chromosome 10 and are deleted in lethal steel mutants. Danielson, K.G., Siracusa, L.D., Donovan, P.J., Iozzo, R.V. Mamm. Genome (1999) [Pubmed]
  5. Expression and localization of PG-Lb/epiphycan during mouse development. Johnson, J., Shinomura, T., Eberspaecher, H., Pinero, G., Decrombrugghe, B., Höök, M. Dev. Dyn. (1999) [Pubmed]
 
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