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EGR4  -  early growth response 4

Homo sapiens

Synonyms: AT133, EGR-4, Early growth response protein 4, NGFI-C, NGFIC, ...
 
 
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Disease relevance of EGR4

  • We therefore examined the effect of 5 and 10 min of global ischemia on the expression of the IEGs NGFI-A, NGFI-B, NGFI-C, egr-2, egr-3, and Nurr1 in gerbil brain [1].
  • In order to characterise the function of the EGR-4 zinc finger protein, we have expressed the protein in the eukaryotic baculovirus system [2].
  • KCC2 luciferase reporter constructs containing the Egr4 site (Egr4(KCC2)) were strongly induced by Egr4 overexpression in neuro-2a neuroblastoma cells and in cultured neurons [3].
 

High impact information on EGR4

 

Biological context of EGR4

  • In NG108-15 cells, dbcAMP excerted a strong enhancing activity on the transactivation properties of NGFI-C while this was not observed when cells were transfected with NGFI-A [7].
  • CAT activity after transfection of the p4000 ChAT-CAT reporter into both neuronal cell lines (NG108-15 and SN6 cells) was increased up to 5-fold in the presence of co-transfected NGFI-A and up to 5- and 12-fold after co-transfection of NGFI-C expression vector in NG108-15 and SN6 cells, respectively [7].
  • The human zinc finger protein EGR-4 acts as autoregulatory transcriptional repressor [2].
  • A G-rich region in the EGR-4 promoter, located at position -106 to -82, could be identified as binding site for the recombinant EGR-4 protein [2].
  • Upregulation of the neuron-specific K+/Cl- cotransporter expression by transcription factor early growth response 4 [3].
 

Analytical, diagnostic and therapeutic context of EGR4

References

  1. Global ischemia induces immediate-early genes encoding zinc finger transcription factors. Honkaniemi, J., Sharp, F.R. J. Cereb. Blood Flow Metab. (1996) [Pubmed]
  2. The human zinc finger protein EGR-4 acts as autoregulatory transcriptional repressor. Zipfel, P.F., Decker, E.L., Holst, C., Skerka, C. Biochim. Biophys. Acta (1997) [Pubmed]
  3. Upregulation of the neuron-specific K+/Cl- cotransporter expression by transcription factor early growth response 4. Uvarov, P., Ludwig, A., Markkanen, M., Rivera, C., Airaksinen, M.S. J. Neurosci. (2006) [Pubmed]
  4. Expression of the early growth response 1 and 2 zinc finger genes during induction of monocytic differentiation. Kharbanda, S., Nakamura, T., Stone, R., Hass, R., Bernstein, S., Datta, R., Sukhatme, V.P., Kufe, D. J. Clin. Invest. (1991) [Pubmed]
  5. Neural-specific expression, genomic structure, and chromosomal localization of the gene encoding the zinc-finger transcription factor NGFI-C. Crosby, S.D., Veile, R.A., Donis-Keller, H., Baraban, J.M., Bhat, R.V., Simburger, K.S., Milbrandt, J. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  6. Expression and function of TRK-B and BDNF in human neuroblastomas. Nakagawara, A., Azar, C.G., Scavarda, N.J., Brodeur, G.M. Mol. Cell. Biol. (1994) [Pubmed]
  7. Transcriptional activation of human choline acetyltransferase by AP2- and NGF-induced factors. Quirin-Stricker, C., Mauvais, C., Schmitt, M. Brain Res. Mol. Brain Res. (1997) [Pubmed]
 
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