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Gene Review

Egr4  -  early growth response 4

Mus musculus

Synonyms: EGR-4, Early growth response protein 4, NGF1-C, NGFI-C, NGFIC, ...
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Disease relevance of Egr4

  • These data raise the possibility that Egr4 may contribute to some forms of human idiopathic male infertility [1].
  • Infertility associated with incomplete spermatogenic arrest and oligozoospermia in Egr4-deficient mice [1].
  • The nerve growth factor-induced clone C (NGFI-C) gene encodes a zinc-finger transcription factor that is rapidly induced by nerve growth factor in rat pheochromocytoma PC12 cells and by seizure in brain [2].

High impact information on Egr4


Biological context of Egr4


Anatomical context of Egr4

  • The pAT133-promoter functions as an inducible promoter in human T cells and in fibroblasts, as constructs containing the bacterial chloramphenicol acetyl transferase (CAT) gene driven by a 943 bp pAT133-promoter fragment were induced in these cells by stimulation with PHA/PMA or by serum, respectively [6].

Associations of Egr4 with chemical compounds


Other interactions of Egr4

  • The genes are closely linked, with 0/215 recombinants between Anx4 and Tgfa and 1/215 recombinants between these genes and Egr4 [5].

Analytical, diagnostic and therapeutic context of Egr4


  1. Infertility associated with incomplete spermatogenic arrest and oligozoospermia in Egr4-deficient mice. Tourtellotte, W.G., Nagarajan, R., Auyeung, A., Mueller, C., Milbrandt, J. Development (1999) [Pubmed]
  2. Neural-specific expression, genomic structure, and chromosomal localization of the gene encoding the zinc-finger transcription factor NGFI-C. Crosby, S.D., Veile, R.A., Donis-Keller, H., Baraban, J.M., Bhat, R.V., Simburger, K.S., Milbrandt, J. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  3. The neuroplasticity-associated arc gene is a direct transcriptional target of early growth response (Egr) transcription factors. Li, L., Carter, J., Gao, X., Whitehead, J., Tourtellotte, W.G. Mol. Cell. Biol. (2005) [Pubmed]
  4. Functional compensation by Egr4 in Egr1-dependent luteinizing hormone regulation and Leydig cell steroidogenesis. Tourtellotte, W.G., Nagarajan, R., Bartke, A., Milbrandt, J. Mol. Cell. Biol. (2000) [Pubmed]
  5. Conserved linkage of early growth response 4, annexin 4, and transforming growth factor alpha on mouse chromosome 6. Barrow, L.L., Simin, K., Jones, J.M., Lee, D.C., Meisler, M.H. Genomics (1994) [Pubmed]
  6. Genomic organization, chromosomal localization and promoter function of the human zinc-finger gene pAT133. Holst, C., Skerka, C., Lichter, P., Bialonski, A., Zipfel, P.F. Hum. Mol. Genet. (1993) [Pubmed]
  7. Early growth response proteins EGR-4 and EGR-3 interact with immune inflammatory mediators NF-kappaB p50 and p65. Wieland, G.D., Nehmann, N., Müller, D., Eibel, H., Siebenlist, U., Sühnel, J., Zipfel, P.F., Skerka, C. J. Cell. Sci. (2005) [Pubmed]
  8. Cloning and characterization of the bovine EGR4 gene and evaluation as candidate gene for bovine spinal dysmyelination. Nissen, P.H., Thomsen, B., Offenberg, H., Thomsen, P.D., Bendixen, C. Anim. Genet. (2003) [Pubmed]
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