Disease relevance of ELF1

• Regulation of the Ets-related transcription factor Elf-1 by binding to the retinoblastoma protein [1].
• We examined the expression of the ELF subfamily of ETS genes (ELF-1, MEF and NERF) in acute myeloid leukemia (AML) cells using Northern blot analysis [2].

High impact information on ELF1

• Characterization of NERF, a novel transcription factor related to the Ets factor ELF-1 [3].
• Comparison of the deduced amino acid sequence of NERF with those of other members of the Ets family reveals that the level of homology to ELF-1, which is involved in the regulation of several T- and B-cell-specific genes, is highest [3].
• Elf-1 (E-74-like factor) is a member of the Ets (E-26-specific) family and is crucial for the basal transcription of TCR zeta-chain in Jurkat cells [4].
• A number of the ETS family of transcription factors are expressed in T cells, including ETS1 and ELF1 [5].
• Exogenous ETS1, but not ELF1, can transactivate GM-CSF, through the GM5 site, in a PMA/ionomycin dependent manner [5].

Biological context of ELF1

• Transcription factors Ets1, Ets2, and Elf1 exhibit differential localization in human endometrium across the menstrual cycle and alternate isoforms in cultured endometrial cells [6].
• Alterations of Fli1 and Elf1 expression are associated with autoimmunity, emphasizing the role of ETS factors as not only positive, but also negative regulators of immunity [7].

Anatomical context of ELF1

• Elf1 was found by immunohistochemistry to be predominantly localized to the glandular epithelium [6].
• Opposing functions of the Ets factors NERF and ELF-1 during chicken blood vessel development [8].

Other interactions of ELF1

• We now report on the cloning and characterization of a novel ETS family member, ELFR, displaying 92% homology to ELF-1 in its DNA binding domain while diverging in the rest of the protein [9].

Analytical, diagnostic and therapeutic context of ELF1

• We also report the chromosomal assignment of ELFR and ELF-1 to Xq26 and 13q13, respectively, by means of fluorescence in-situ hybridization (FISH) [9].

References