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Gene Review

ELF1  -  E74-like factor 1 (ets domain...

Homo sapiens

Synonyms: E74-like factor 1, ETS-related transcription factor Elf-1
 
 
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Disease relevance of ELF1

 

High impact information on ELF1

  • Characterization of NERF, a novel transcription factor related to the Ets factor ELF-1 [3].
  • Comparison of the deduced amino acid sequence of NERF with those of other members of the Ets family reveals that the level of homology to ELF-1, which is involved in the regulation of several T- and B-cell-specific genes, is highest [3].
  • Elf-1 (E-74-like factor) is a member of the Ets (E-26-specific) family and is crucial for the basal transcription of TCR zeta-chain in Jurkat cells [4].
  • A number of the ETS family of transcription factors are expressed in T cells, including ETS1 and ELF1 [5].
  • Exogenous ETS1, but not ELF1, can transactivate GM-CSF, through the GM5 site, in a PMA/ionomycin dependent manner [5].
 

Biological context of ELF1

  • Transcription factors Ets1, Ets2, and Elf1 exhibit differential localization in human endometrium across the menstrual cycle and alternate isoforms in cultured endometrial cells [6].
  • Alterations of Fli1 and Elf1 expression are associated with autoimmunity, emphasizing the role of ETS factors as not only positive, but also negative regulators of immunity [7].
 

Anatomical context of ELF1

 

Other interactions of ELF1

  • We now report on the cloning and characterization of a novel ETS family member, ELFR, displaying 92% homology to ELF-1 in its DNA binding domain while diverging in the rest of the protein [9].
 

Analytical, diagnostic and therapeutic context of ELF1

References

  1. Regulation of the Ets-related transcription factor Elf-1 by binding to the retinoblastoma protein. Wang, C.Y., Petryniak, B., Thompson, C.B., Kaelin, W.G., Leiden, J.M. Science (1993) [Pubmed]
  2. The level of MEF but not ELF-1 correlates with FAB subtype of acute myeloid leukemia and is low in good prognosis cases. Fukushima, T., Miyazaki, Y., Tsushima, H., Tsutsumi, C., Taguchi, J., Yoshida, S., Kuriyama, K., Scadden, D., Nimer, S., Tomonaga, M. Leuk. Res. (2003) [Pubmed]
  3. Characterization of NERF, a novel transcription factor related to the Ets factor ELF-1. Oettgen, P., Akbarali, Y., Boltax, J., Best, J., Kunsch, C., Libermann, T.A. Mol. Cell. Biol. (1996) [Pubmed]
  4. Defective production of functional 98-kDa form of Elf-1 is responsible for the decreased expression of TCR zeta-chain in patients with systemic lupus erythematosus. Juang, Y.T., Tenbrock, K., Nambiar, M.P., Gourley, M.F., Tsokos, G.C. J. Immunol. (2002) [Pubmed]
  5. ETS1 transactivates the human GM-CSF promoter in Jurkat T cells stimulated with PMA and ionomycin. Thomas, R.S., Tymms, M.J., Seth, A., Shannon, M.F., Kola, I. Oncogene (1995) [Pubmed]
  6. Transcription factors Ets1, Ets2, and Elf1 exhibit differential localization in human endometrium across the menstrual cycle and alternate isoforms in cultured endometrial cells. Kilpatrick, L.M., Kola, I., Salamonsen, L.A. Biol. Reprod. (1999) [Pubmed]
  7. ETS transcription factors and regulation of immunity. Gallant, S., Gilkeson, G. Arch. Immunol. Ther. Exp. (Warsz.) (2006) [Pubmed]
  8. Opposing functions of the Ets factors NERF and ELF-1 during chicken blood vessel development. Gaspar, J., Thai, S., Voland, C., Dube, A., Libermann, T.A., Iruela-Arispe, M.L., Oettgen, P. Arterioscler. Thromb. Vasc. Biol. (2002) [Pubmed]
  9. Cloning of a novel human ELF-1-related ETS transcription factor, ELFR, its characterization and chromosomal assignment relative to ELF-1. Aryee, D.N., Petermann, R., Kos, K., Henn, T., Haas, O.A., Kovar, H. Gene (1998) [Pubmed]
 
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