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Gene Review

EPB41L1  -  erythrocyte membrane protein band 4.1-like 1

Homo sapiens

Synonyms: 4.1N, Band 4.1-like protein 1, KIAA0338, MRD11, Neuronal protein 4.1
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Disease relevance of EPB41L1


High impact information on EPB41L1

  • C-terminal palmitoylation decreases interaction of the AMPA receptor with the 4.1N protein and regulates AMPA- and NMDA-induced AMPA receptor internalization [2].
  • Association of the type 1 inositol (1,4,5)-trisphosphate receptor with 4.1N protein in neurons [3].
  • From our findings we hypothesize that InsP(3)R1-4.1N association may play a role in InsP(3)R1 localization or Ca(2+) signaling in neurons [3].
  • In yeast two-hybrid screen of rat brain cDNA library with the InsP(3)R1 carboxy-terminal bait we isolated multiple clones of neuronal cytoskeletal protein 4.1N [3].
  • We showed that both 4.1N and InsP(3)R1 were enriched in synaptic locations and immunoprecipitated the 4.1N-InsP(3)R1 complex from rat brain synaptosomes [3].

Biological context of EPB41L1


Anatomical context of EPB41L1


Associations of EPB41L1 with chemical compounds

  • We identified protein 4.1N as a D2-like dopamine receptor-interacting protein in a yeast two-hybrid screen [1].
  • Using comparative immunoblot analysis, we found that treatment with either haloperidol or clozapine increased D2 dopamine receptors, calcium activator protein for secretion, protein 4.1N, and neuronal calcium sensor-1 expression [8].

Physical interactions of EPB41L1


Other interactions of EPB41L1

  • We also found that 4.1N can associate with GluR1 in vivo and colocalizes with AMPA receptors at excitatory synapses [6].
  • Thus, 4.1N, 4.1B and 4.1G all show high accumulation in nervous tissues. mRNA for betaIISigma2-spectrin is ubiquitous, but most abundant in cardiac and nervous tissues [7].


  1. D2 and D3 dopamine receptor cell surface localization mediated by interaction with protein 4.1N. Binda, A.V., Kabbani, N., Lin, R., Levenson, R. Mol. Pharmacol. (2002) [Pubmed]
  2. Differential regulation of AMPA receptor subunit trafficking by palmitoylation of two distinct sites. Hayashi, T., Rumbaugh, G., Huganir, R.L. Neuron (2005) [Pubmed]
  3. Association of the type 1 inositol (1,4,5)-trisphosphate receptor with 4.1N protein in neurons. Maximov, A., Tang, T.S., Bezprozvanny, I. Mol. Cell. Neurosci. (2003) [Pubmed]
  4. Radiation hybrid mapping of EPB41L1, a novel protein 4.1 homologue, to human chromosome 20q11.2-q12. Kim, A.C., Van Huffel, C., Lutchman, M., Chishti, A.H. Genomics (1998) [Pubmed]
  5. Protein 4.1N binding to nuclear mitotic apparatus protein in PC12 cells mediates the antiproliferative actions of nerve growth factor. Ye, K., Compton, D.A., Lai, M.M., Walensky, L.D., Snyder, S.H. J. Neurosci. (1999) [Pubmed]
  6. Regulation of AMPA receptor GluR1 subunit surface expression by a 4. 1N-linked actin cytoskeletal association. Shen, L., Liang, F., Walensky, L.D., Huganir, R.L. J. Neurosci. (2000) [Pubmed]
  7. Expression of human membrane skeleton protein genes for protein 4.1 and betaIISigma2-spectrin assayed by real-time RT-PCR. Taylor-Harris, P.M., Felkin, L.E., Birks, E.J., Franklin, R.C., Yacoub, M.H., Baines, A.J., Barton, P.J., Pinder, J.C. Cell. Mol. Biol. Lett. (2005) [Pubmed]
  8. Antipsychotic-induced alterations in D2 dopamine receptor interacting proteins within the cortex. Kabbani, N., Levenson, R. Neuroreport (2006) [Pubmed]
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