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Gene Review

St3gal4  -  ST3 beta-galactoside alpha-2,3...

Mus musculus

Synonyms: Alpha 2,3-ST 4, Alpha 2,3-sialyltransferase IV, Beta-galactoside alpha-2,3-sialyltransferase 4, CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4, Gal-beta-1,4-GalNAc-alpha-2,3-sialyltransferase, ...
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High impact information on St3gal4

  • Among neutrophils, only ST3Gal-IV was found to play a role in the synthesis of selectin ligands [1].
  • Our findings indicate a high degree of functional specificity among sialyltransferases and a substantial role for ST3Gal-IV in selectin ligand formation [1].
  • In cremaster muscle venules with or without TNF-alpha treatment, L-selectin-dependent rolling was almost completely abolished in ST3Gal-IV(-/-) mice [2].
  • Time course analyses revealed early (within 48 h of infection) induction of Siat4c, Sprr2A, and Relmbeta and later (within 120 h) induction of Mcpt-1 and -2 [3].
  • The early epithelial responses may be associated both with repair (Sprr2A) and with the development of innate immunity (Siat4c and Relmbeta) [3].

Biological context of St3gal4


Anatomical context of St3gal4

  • We used lectin binding and flow cytometry combined with relative real-time PCR to show that MAH and PNA binding are tightly correlated with the abundance of ST3Gal IV and ST3Gal I mRNA, respectively, under several different conditions of B cell stimulation [6].

Other interactions of St3gal4

  • Mouse gene knockout studies have provided unimpeachable evidence of immune-relevant functions for several sialyltransferase enzymes including ST6Gal I, ST3Gal I, and ST3Gal IV [6].


  1. Sialyltransferase specificity in selectin ligand formation. Ellies, L.G., Sperandio, M., Underhill, G.H., Yousif, J., Smith, M., Priatel, J.J., Kansas, G.S., Ley, K., Marth, J.D. Blood (2002) [Pubmed]
  2. alpha2,3-Sialyltransferase-IV is essential for L-selectin ligand function in inflammation. Sperandio, M., Frommhold, D., Babushkina, I., Ellies, L.G., Olson, T.S., Smith, M.L., Fritzsching, B., Pauly, E., Smith, D.F., Nobiling, R., Linderkamp, O., Marth, J.D., Ley, K. Eur. J. Immunol. (2006) [Pubmed]
  3. Expression profiling reveals novel innate and inflammatory responses in the jejunal epithelial compartment during infection with Trichinella spiralis. Knight, P.A., Pemberton, A.D., Robertson, K.A., Roy, D.J., Wright, S.H., Miller, H.R. Infect. Immun. (2004) [Pubmed]
  4. Comparison of genomic structures of four members of beta-galactoside alpha2,3-sialyltransferase genes in the mouse. Takashima, S., Tsuji, S. Cytogenet. Cell Genet. (2000) [Pubmed]
  5. Region-specific and epileptogenic-dependent expression of six subtypes of alpha2,3-sialyltransferase in the adult mouse brain. Matsuhashi, H., Horii, Y., Kato, K. J. Neurochem. (2003) [Pubmed]
  6. Sialyltransferase mRNA abundances in B cells are strictly controlled, correlated with cognate lectin binding, and differentially responsive to immune signaling in vitro. Marino, J.H., Hoffman, M., Meyer, M., Miller, K.S. Glycobiology (2004) [Pubmed]
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