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Gene Review

Sell  -  selectin, lymphocyte

Mus musculus

Synonyms: AI528707, CD62 antigen-like family member L, CD62L, L-selectin, LAM-1, ...
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Disease relevance of Sell


High impact information on Sell

  • Autoreactive T cells specific to these autoantigens are present in most normal individuals but are kept under control by a number of peripheral tolerance mechanisms, among which CD4(+) CD25(+) CD62L(+) T cell-mediated regulation probably plays a central role [6].
  • These results identify Core1-beta 3GlcNAcT and its cognate extended core1 O-glycans as essential participants in the expression of the MECA-79-positive, HEV-specific L-selectin ligands required for lymphocyte homing [7].
  • L-selectin mediates lymphocyte homing by facilitating lymphocyte adhesion to addressins expressed in the high endothelial venules (HEV) of secondary lymphoid organs [7].
  • These observations demonstrate an essential role for Fuc-TVII in E-, P-, and L-selectin ligand biosynthesis and imply that this locus can control leukocyte trafficking in health and disease [8].
  • Moreover, alpha 4 beta 7 mediates L-selectin (CD62L)-independent attachment of blood-borne lymphocytes to lamina propria venules in situ [9].

Chemical compound and disease context of Sell


Biological context of Sell


Anatomical context of Sell


Associations of Sell with chemical compounds


Physical interactions of Sell

  • At concentrations just above its mean serum level (approximately 1.5 microg/ml or approximately 30 nM), GlyCAM-1 binds multivalently to immobilized CD62L [24].
  • Initially we used fluorescent microspheres to study the potential of L-selectin and the minimal selectin ligand sialyl Lewis(x) (sLe(x)) to interact with postcapillary venules in the absence of PSGL-1 [25].
  • Compounds 1 and 2 were 2 times more potent than the sLe(X) tetrasaccharide toward E-selectin binding and up to 4 times more potent than sLe(X) toward P- and L-selectin binding [26].

Regulatory relationships of Sell


Other interactions of Sell


Analytical, diagnostic and therapeutic context of Sell


  1. Dermal and pulmonary inflammatory disease in E-selectin and P-selectin double-null mice is reduced in triple-selectin-null mice. Collins, R.G., Jung, U., Ramirez, M., Bullard, D.C., Hicks, M.J., Smith, C.W., Ley, K., Beaudet, A.L. Blood (2001) [Pubmed]
  2. L-selectin facilitation of metastasis involves temporal induction of Fut7-dependent ligands at sites of tumor cell arrest. Läubli, H., Stevenson, J.L., Varki, A., Varki, N.M., Borsig, L. Cancer Res. (2006) [Pubmed]
  3. Pathophysiologic importance of E- and L-selectin for neutrophil-induced liver injury during endotoxemia in mice. Lawson, J.A., Burns, A.R., Farhood, A., Lynn Bajt, M., Collins, R.G., Smith, C.W., Jaeschke, H. Hepatology (2000) [Pubmed]
  4. The cutaneous reverse Arthus reaction requires intercellular adhesion molecule 1 and L-selectin expression. Kaburagi, Y., Hasegawa, M., Nagaoka, T., Shimada, Y., Hamaguchi, Y., Komura, K., Saito, E., Yanaba, K., Takehara, K., Kadono, T., Steeber, D.A., Tedder, T.F., Sato, S. J. Immunol. (2002) [Pubmed]
  5. Functions of glycans revealed by gene inactivation of L-selectin ligand sulfotransferases in mice. Kawashima, H. Meth. Enzymol. (2006) [Pubmed]
  6. Tolerance to islet autoantigens in type 1 diabetes. Bach, J.F., Chatenoud, L. Annu. Rev. Immunol. (2001) [Pubmed]
  7. Novel sulfated lymphocyte homing receptors and their control by a Core1 extension beta 1,3-N-acetylglucosaminyltransferase. Yeh, J.C., Hiraoka, N., Petryniak, B., Nakayama, J., Ellies, L.G., Rabuka, D., Hindsgaul, O., Marth, J.D., Lowe, J.B., Fukuda, M. Cell (2001) [Pubmed]
  8. The alpha(1,3)fucosyltransferase Fuc-TVII controls leukocyte trafficking through an essential role in L-, E-, and P-selectin ligand biosynthesis. Malý, P., Thall, A., Petryniak, B., Rogers, C.E., Smith, P.L., Marks, R.M., Kelly, R.J., Gersten, K.M., Cheng, G., Saunders, T.L., Camper, S.A., Camphausen, R.T., Sullivan, F.X., Isogai, Y., Hindsgaul, O., von Andrian, U.H., Lowe, J.B. Cell (1996) [Pubmed]
  9. alpha 4 integrins mediate lymphocyte attachment and rolling under physiologic flow. Berlin, C., Bargatze, R.F., Campbell, J.J., von Andrian, U.H., Szabo, M.C., Hasslen, S.R., Nelson, R.D., Berg, E.L., Erlandsen, S.L., Butcher, E.C. Cell (1995) [Pubmed]
  10. Intercellular adhesion molecule-1 and L-selectin regulate bleomycin-induced lung fibrosis. Hamaguchi, Y., Nishizawa, Y., Yasui, M., Hasegawa, M., Kaburagi, Y., Komura, K., Nagaoka, T., Saito, E., Shimada, Y., Takehara, K., Kadono, T., Steeber, D.A., Tedder, T.F., Sato, S. Am. J. Pathol. (2002) [Pubmed]
  11. Evaluation of antiinflammatory and antiadhesive effects of heparins in human endotoxemia. Derhaschnig, U., Pernerstorfer, T., Knechtelsdorfer, M., Hollenstein, U., Panzer, S., Jilma, B. Crit. Care Med. (2003) [Pubmed]
  12. The polysaccharide fucoidan inhibits microvascular thrombus formation independently from P- and L-selectin function in vivo. Thorlacius, H., Vollmar, B., Seyfert, U.T., Vestweber, D., Menger, M.D. Eur. J. Clin. Invest. (2000) [Pubmed]
  13. Fever-range hyperthermia stimulates alpha4beta7 integrin-dependent lymphocyte-endothelial adhesion. Evans, S.S., Bain, M.D., Wang, W.C. International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group. (2000) [Pubmed]
  14. Selectin-mucin interactions as a probable molecular explanation for the association of Trousseau syndrome with mucinous adenocarcinomas. Wahrenbrock, M., Borsig, L., Le, D., Varki, N., Varki, A. J. Clin. Invest. (2003) [Pubmed]
  15. Regulation of adhesion molecule expression by CD8 T cells in vivo. II. Expression of L-selectin (CD62L) by memory cytolytic T cells responding to minor histocompatibility antigens. Mobley, J.L., Rigby, S.M., Dailey, M.O. J. Immunol. (1994) [Pubmed]
  16. Functional properties and lineage relationship of CD8+ T cell subsets identified by expression of IL-7 receptor alpha and CD62L. Bachmann, M.F., Wolint, P., Schwarz, K., Jäger, P., Oxenius, A. J. Immunol. (2005) [Pubmed]
  17. Structure and chromosomal localization of the murine gene encoding GLYCAM 1. A mucin-like endothelial ligand for L selectin. Dowbenko, D., Andalibi, A., Young, P.E., Lusis, A.J., Lasky, L.A. J. Biol. Chem. (1993) [Pubmed]
  18. The Trypanosoma cruzi membrane mucin AgC10 inhibits T cell activation and IL-2 transcription through L-selectin. Alcaide, P., Fresno, M. Int. Immunol. (2004) [Pubmed]
  19. A novel, high endothelial venule-specific sulfotransferase expresses 6-sulfo sialyl Lewis(x), an L-selectin ligand displayed by CD34. Hiraoka, N., Petryniak, B., Nakayama, J., Tsuboi, S., Suzuki, M., Yeh, J.C., Izawa, D., Tanaka, T., Miyasaka, M., Lowe, J.B., Fukuda, M. Immunity (1999) [Pubmed]
  20. Characterization of a functionally important and evolutionarily well-conserved epitope mapped to the short consensus repeats of E-selectin and L-selectin. Jutila, M.A., Watts, G., Walcheck, B., Kansas, G.S. J. Exp. Med. (1992) [Pubmed]
  21. P-selectin glycoprotein ligand-1 mediates L-selectin-dependent leukocyte rolling in venules. Sperandio, M., Smith, M.L., Forlow, S.B., Olson, T.S., Xia, L., McEver, R.P., Ley, K. J. Exp. Med. (2003) [Pubmed]
  22. Lymphocyte homing to bronchus-associated lymphoid tissue (BALT) is mediated by L-selectin/PNAd, alpha4beta1 integrin/VCAM-1, and LFA-1 adhesion pathways. Xu, B., Wagner, N., Pham, L.N., Magno, V., Shan, Z., Butcher, E.C., Michie, S.A. J. Exp. Med. (2003) [Pubmed]
  23. Lymphocyte-HEV interactions in lymph nodes of a sulfotransferase-deficient mouse. van Zante, A., Gauguet, J.M., Bistrup, A., Tsay, D., von Andrian, U.H., Rosen, S.D. J. Exp. Med. (2003) [Pubmed]
  24. Affinity and kinetic analysis of L-selectin (CD62L) binding to glycosylation-dependent cell-adhesion molecule-1. Nicholson, M.W., Barclay, A.N., Singer, M.S., Rosen, S.D., van der Merwe, P.A. J. Biol. Chem. (1998) [Pubmed]
  25. L- and P-selectins collaborate to support leukocyte rolling in vivo when high-affinity P-selectin-P-selectin glycoprotein ligand-1 interaction is inhibited. Ridger, V.C., Hellewell, P.G., Norman, K.E. Am. J. Pathol. (2005) [Pubmed]
  26. Studies on selectin blockers. 2. Novel selectin blocker as potential therapeutics for inflammatory disorders. Wada, Y., Saito, T., Matsuda, N., Ohmoto, H., Yoshino, K., Ohashi, M., Kondo, H., Ishida, H., Kiso, M., Hasegawa, A. J. Med. Chem. (1996) [Pubmed]
  27. Gene-targeted mice reveal importance of L-selectin-dependent rolling for neutrophil adhesion. Jung, U., Ramos, C.L., Bullard, D.C., Ley, K. Am. J. Physiol. (1998) [Pubmed]
  28. P-Selectin glycoprotein ligand 1 (PSGL-1) is a physiological ligand for E-selectin in mediating T helper 1 lymphocyte migration. Hirata, T., Merrill-Skoloff, G., Aab, M., Yang, J., Furie, B.C., Furie, B. J. Exp. Med. (2000) [Pubmed]
  29. A novel endothelial L-selectin ligand activity in lymph node medulla that is regulated by alpha(1,3)-fucosyltransferase-IV. M'Rini, C., Cheng, G., Schweitzer, C., Cavanagh, L.L., Palframan, R.T., Mempel, T.R., Warnock, R.A., Lowe, J.B., Quackenbush, E.J., von Andrian, U.H. J. Exp. Med. (2003) [Pubmed]
  30. Hematopoietic progenitor cell rolling in bone marrow microvessels: parallel contributions by endothelial selectins and vascular cell adhesion molecule 1. Mazo, I.B., Gutierrez-Ramos, J.C., Frenette, P.S., Hynes, R.O., Wagner, D.D., von Andrian, U.H. J. Exp. Med. (1998) [Pubmed]
  31. Dendritic cell-expanded, islet-specific CD4+ CD25+ CD62L+ regulatory T cells restore normoglycemia in diabetic NOD mice. Tarbell, K.V., Petit, L., Zuo, X., Toy, P., Luo, X., Mqadmi, A., Yang, H., Suthanthiran, M., Mojsov, S., Steinman, R.M. J. Exp. Med. (2007) [Pubmed]
  32. The subpopulation of CD4+CD25+ splenocytes that delays adoptive transfer of diabetes expresses L-selectin and high levels of CCR7. Szanya, V., Ermann, J., Taylor, C., Holness, C., Fathman, C.G. J. Immunol. (2002) [Pubmed]
  33. Differential expression and function of L-selectin on CD56bright and CD56dim natural killer cell subsets. Frey, M., Packianathan, N.B., Fehniger, T.A., Ross, M.E., Wang, W.C., Stewart, C.C., Caligiuri, M.A., Evans, S.S. J. Immunol. (1998) [Pubmed]
  34. L-selectin is involved in lymphocyte migration to sites of inflammation in the skin: delayed rejection of allografts in L-selectin-deficient mice. Tang, M.L., Hale, L.P., Steeber, D.A., Tedder, T.F. J. Immunol. (1997) [Pubmed]
  35. L- and E-selectin can recognize the same naturally occurring ligands on high endothelial venules. Mebius, R.E., Watson, S.R. J. Immunol. (1993) [Pubmed]
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