The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Slc22a5  -  solute carrier family 22 (organic cation...

Mus musculus

Synonyms: High-affinity sodium-dependent carnitine cotransporter, Lstpl, Octn2, Organic cation/carnitine transporter 2, Solute carrier family 22 member 5, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on Slc22a5


Biological context of Slc22a5


Anatomical context of Slc22a5


Associations of Slc22a5 with chemical compounds

  • Carnitine-deficient jvs mice expressed reduced levels of a group of genes which are preferentially expressed in the liver, including urea cycle enzyme genes (Biochim. Biophys. Acta 1138, 167-171, 1992) [5].
  • Externally added ALCAR showed significantly slower initial uptake across the BBB in jvs mouse [8].

Other interactions of Slc22a5

  • On the other hand, GR protein accumulated in the nuclear fraction in jvs mice [5].
  • The expression of alpha-fetoprotein and aldolase A was elevated, indicating that the liver of jvs mice is undifferentiated or dedifferentiated (FEBS Lett. 311, 63-66, 1992) [5].


  1. Primary systemic carnitine deficiency is caused by mutations in a gene encoding sodium ion-dependent carnitine transporter. Nezu, J., Tamai, I., Oku, A., Ohashi, R., Yabuuchi, H., Hashimoto, N., Nikaido, H., Sai, Y., Koizumi, A., Shoji, Y., Takada, G., Matsuishi, T., Yoshino, M., Kato, H., Ohura, T., Tsujimoto, G., Hayakawa, J., Shimane, M., Tsuji, A. Nat. Genet. (1999) [Pubmed]
  2. Loss of wild-type carrier-mediated L-carnitine transport activity in hepatocytes of juvenile visceral steatosis mice. Yokogawa, K., Yonekawa, M., Tamai, I., Ohashi, R., Tatsumi, Y., Higashi, Y., Nomura, M., Hashimoto, N., Nikaido, H., Hayakawa, J., Nezu, J., Oku, A., Shimane, M., Miyamoto, K., Tsuji, A. Hepatology (1999) [Pubmed]
  3. Organic cation/carnitine transporter OCTN2 (Slc22a5) is responsible for carnitine transport across apical membranes of small intestinal epithelial cells in mouse. Kato, Y., Sugiura, M., Sugiura, T., Wakayama, T., Kubo, Y., Kobayashi, D., Sai, Y., Tamai, I., Iseki, S., Tsuji, A. Mol. Pharmacol. (2006) [Pubmed]
  4. Tissue distribution and ontogeny of organic cation transporters in mice. Alnouti, Y., Petrick, J.S., Klaassen, C.D. Drug Metab. Dispos. (2006) [Pubmed]
  5. Abnormal gene expression and regulation in the liver of jvs mice with systemic carnitine deficiency. Tomomura, M., Imamura, Y., Tomomura, A., Horiuchi, M., Saheki, T. Biochim. Biophys. Acta (1994) [Pubmed]
  6. Activities of cytochrome p450 enzymes in liver and kidney microsomes from systemic carnitine deficiency mice with a gene mutation of carnitine/organic cation transporter. Yamazaki, H., Iketaki, H., Shibata, A., Nakajima, M., Yokoi, T. Drug Metab. Pharmacokinet. (2002) [Pubmed]
  7. Mapping of jvs (juvenile visceral steatosis) gene, which causes systemic carnitine deficiency in mice, on chromosome 11. Nikaido, H., Horiuchi, M., Hashimoto, N., Saheki, T., Hayakawa, J. Mamm. Genome (1995) [Pubmed]
  8. Acetyl-L-carnitine permeability across the blood-brain barrier and involvement of carnitine transporter OCTN2. Inano, A., Sai, Y., Nikaido, H., Hasimoto, N., Asano, M., Tsuji, A., Tamai, I. Biopharmaceutics & drug disposition. (2003) [Pubmed]
WikiGenes - Universities