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Gene Review

Slc22a5  -  solute carrier family 22 (organic...

Rattus norvegicus

Synonyms: CT1, High-affinity sodium-dependent carnitine cotransporter, OCTN2, Octn2, Organic cation/carnitine transporter 2, ...
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Disease relevance of Slc22a5


High impact information on Slc22a5


Biological context of Slc22a5


Anatomical context of Slc22a5


Associations of Slc22a5 with chemical compounds

  • The replacement of extracellular sodium with Li reduced CT1-mediated L-carnitine uptake to 19.8% [12].
  • CT1 did not transport typical substrates for either organic anion or organic cation transporters, such as p-aminohippurate and tetraethylammonium [12].
  • Octanoylcarnitine, acetylcarnitine, and gamma-butyrobetaine showed potent inhibitory effects on CT1-mediated L-carnitine uptake; betaine and d-carnitine showed moderate inhibition [12].
  • Simvastatin was proved, in a dose-independent manner, to decrease cardiacmyocytes size as well as protein synthesis, and inhibit ANP mRNA synthesis and JAK-STAT protein expression induced by CT-1 in cardiacmyocytes.Conclusion: These results suggest that simvastatin can ameliorate cardiacmyocytes hypertrophyin vitrovia JAK-STAT signaling pathways [14].
  • OCTN2 transports organic cations without involving Na(+), but it transports carnitine only in the presence of Na(+) [7].

Other interactions of Slc22a5


Analytical, diagnostic and therapeutic context of Slc22a5


  1. Organic cation transporter mRNA and function in the rat superior cervical ganglion. Kristufek, D., Rudorfer, W., Pifl, C., Huck, S. J. Physiol. (Lond.) (2002) [Pubmed]
  2. Gene transfer of glial cell-derived neurotrophic factor and cardiotrophin-1 protects PC12 cells from injury: involvement of the phosphatidylinositol 3-kinase and mitogen-activated protein kinase kinase pathways. Toth, G., Yang, H., Anguelov, R.A., Vettraino, J., Wang, Y., Acsadi, G. J. Neurosci. Res. (2002) [Pubmed]
  3. Therapeutic potential of cardiotrophin 1 in fulminant hepatic failure: dual roles in antiapoptosis and cell repair. Ho, D.W., Yang, Z.F., Lau, C.K., Tam, K.H., To, J.Y., Poon, R.T., Fan, S.T. Archives of surgery (Chicago, Ill. : 1960) (2006) [Pubmed]
  4. Increase of Cardiotrophin-1 immunoreactivity in regenerating and overloaded but not denervated muscles of rats. Nishikawa, J., Sakuma, K., Sorimachi, Y., Yoshimoto, K., Yasuhara, M. Neuropathology : official journal of the Japanese Society of Neuropathology. (2005) [Pubmed]
  5. beta-lactam antibiotics as substrates for OCTN2, an organic cation/carnitine transporter. Ganapathy, M.E., Huang, W., Rajan, D.P., Carter, A.L., Sugawara, M., Iseki, K., Leibach, F.H., Ganapathy, V. J. Biol. Chem. (2000) [Pubmed]
  6. Transplantation of cardiotrophin-1-expressing myoblasts to the left ventricular wall alleviates the transition from compensatory hypertrophy to congestive heart failure in Dahl salt-sensitive hypertensive rats. Toh, R., Kawashima, S., Kawai, M., Sakoda, T., Ueyama, T., Satomi-Kobayashi, S., Hirayama, S., Yokoyama, M. J. Am. Coll. Cardiol. (2004) [Pubmed]
  7. Functional characteristics and tissue distribution pattern of organic cation transporter 2 (OCTN2), an organic cation/carnitine transporter. Wu, X., Huang, W., Prasad, P.D., Seth, P., Rajan, D.P., Leibach, F.H., Chen, J., Conway, S.J., Ganapathy, V. J. Pharmacol. Exp. Ther. (1999) [Pubmed]
  8. Functional relevance of carnitine transporter OCTN2 to brain distribution of L-carnitine and acetyl-L-carnitine across the blood-brain barrier. Kido, Y., Tamai, I., Ohnari, A., Sai, Y., Kagami, T., Nezu, J., Nikaido, H., Hashimoto, N., Asano, M., Tsuji, A. J. Neurochem. (2001) [Pubmed]
  9. Organic cation/carnitine transporter, OCTN2, is differentially expressed in the adult rat epididymis. Rodríguez, C.M., Labus, J.C., Hinton, B.T. Biol. Reprod. (2002) [Pubmed]
  10. L-carnitine transport in kidney of normotensive, Wistar-Kyoto rats: effect of chronic L-carnitine administration. Gómez-Amores, L., Mate, A., Vázquez, C.M. Pharm. Res. (2003) [Pubmed]
  11. Molecular cloning and functional characterization of the OCTN2 transporter at the RBE4 cells, an in vitro model of the blood-brain barrier. Friedrich, A., Prasad, P.D., Freyer, D., Ganapathy, V., Brust, P. Brain Res. (2003) [Pubmed]
  12. Molecular cloning and characterization of high-affinity carnitine transporter from rat intestine. Sekine, T., Kusuhara, H., Utsunomiya-Tate, N., Tsuda, M., Sugiyama, Y., Kanai, Y., Endou, H. Biochem. Biophys. Res. Commun. (1998) [Pubmed]
  13. OCTN3: A Na+-independent L-carnitine transporter in enterocytes basolateral membrane. Durán, J.M., Peral, M.J., Calonge, M.L., Ilundáin, A.A. J. Cell. Physiol. (2005) [Pubmed]
  14. Simvastatin attenuates hypertrophic responses induced by cardiotrophin-1 via JAK-STAT pathway in cultured cardiomyocytes. Wu, L., Zhao, L., Zheng, Q., Shang, F., Wang, X., Wang, L., Lang, B. Mol. Cell. Biochem. (2006) [Pubmed]
  15. Oligonucleotide microarray analysis of differential transporter regulation in the regenerating rat liver. Dransfeld, O., Gehrmann, T., Köhrer, K., Kircheis, G., Holneicher, C., Häussinger, D., Wettstein, M. Liver Int. (2005) [Pubmed]
  16. Acetyl-L-carnitine prevents total body hydroxyl free radical and uric acid production induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in the rat. Loots, d.u. .T., Mienie, L.J., Bergh, J.J., Van der Schyf, C.J. Life Sci. (2004) [Pubmed]
  17. Studies on intestinal absorption of sulpiride (3): intestinal absorption of sulpiride in rats. Watanabe, K., Sawano, T., Jinriki, T., Sato, J. Biol. Pharm. Bull. (2004) [Pubmed]
  18. Na(+)-coupled transport of L-carnitine via high-affinity carnitine transporter OCTN2 and its subcellular localization in kidney. Tamai, I., China, K., Sai, Y., Kobayashi, D., Nezu, J., Kawahara, E., Tsuji, A. Biochim. Biophys. Acta (2001) [Pubmed]
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