Gene Review:
Sp4 - trans-acting transcription factor 4
Mus musculus
Synonyms:
5730497N03Rik, HF-1b, HF1-b, Transcription factor Sp4
- Tolfenamic acid and pancreatic cancer growth, angiogenesis, and Sp protein degradation. Abdelrahim, M., Baker, C.H., Abbruzzese, J.L., Safe, S. J. Natl. Cancer Inst. (2006)
- A novel genetic pathway for sudden cardiac death via defects in the transition between ventricular and conduction system cell lineages. Nguyên-Trân, V.T., Kubalak, S.W., Minamisawa, S., Fiset, C., Wollert, K.C., Brown, A.B., Ruiz-Lozano, P., Barrere-Lemaire, S., Kondo, R., Norman, L.W., Gourdie, R.G., Rahme, M.M., Feld, G.K., Clark, R.B., Giles, W.R., Chien, K.R. Cell (2000)
- Knockout of the neural and heart expressed gene HF-1b results in apical deficits of ventricular structure and activation. Hewett, K.W., Norman, L.W., Sedmera, D., Barker, R.J., Justus, C., Zhang, J., Kubalak, S.W., Gourdie, R.G. Cardiovasc. Res. (2005)
- An inhibitor domain in Sp3 regulates its glutamine-rich activation domains. Dennig, J., Beato, M., Suske, G. EMBO J. (1996)
- Expression of an LMNA-N195K variant of A-type lamins results in cardiac conduction defects and death in mice. Mounkes, L.C., Kozlov, S.V., Rottman, J.N., Stewart, C.L. Hum. Mol. Genet. (2005)
- Inhibition of cyclin D1 kinase activity is associated with E2F-mediated inhibition of cyclin D1 promoter activity through E2F and Sp1. Watanabe, G., Albanese, C., Lee, R.J., Reutens, A., Vairo, G., Henglein, B., Pestell, R.G. Mol. Cell. Biol. (1998)
- An HF-1a/HF-1b/MEF-2 combinatorial element confers cardiac ventricular specificity and established an anterior-posterior gradient of expression. Ross, R.S., Navankasattusas, S., Harvey, R.P., Chien, K.R. Development (1996)
- Transcriptional regulation of the mouse gene encoding the alpha-4 subunit of the GABAA receptor. Ma, L., Song, L., Radoi, G.E., Harrison, N.L. J. Biol. Chem. (2004)
- Complex phenotype of mice homozygous for a null mutation in the Sp4 transcription factor gene. Göllner, H., Bouwman, P., Mangold, M., Karis, A., Braun, H., Rohner, I., Del Rey, A., Besedovsky, H.O., Meinhardt, A., van den Broek, M., Cutforth, T., Grosveld, F., Philipsen, S., Suske, G. Genes Cells (2001)
- Characterization and promoter analysis of the mouse gene for transcription factor Sp4. Song, J., Mangold, M., Suske, G., Geltinger, C., Kanazawa, I., Sun, K., Yokoyama, K.K. Gene (2001)
- In vivo roles of RORalpha and Sp4 in the regulation of murine prosaposin gene. Jin, P., Sun, Y., Grabowski, G.A. DNA Cell Biol. (2001)
- Distinct roles of HF-1b/Sp4 in ventricular and neural crest cells lineages affect cardiac conduction system development. St Amand, T.R., Lu, J.T., Zamora, M., Gu, Y., Stricker, J., Hoshijima, M., Epstein, J.A., Ross, J.J., Ruiz-Lozano, P., Chien, K.R. Dev. Biol. (2006)
- Positive regulatory elements (HF-1a and HF-1b) and a novel negative regulatory element (HF-3) mediate ventricular muscle-specific expression of myosin light-chain 2-luciferase fusion genes in transgenic mice. Lee, K.J., Hickey, R., Zhu, H., Chien, K.R. Mol. Cell. Biol. (1994)
- Reduced expression of the Sp4 gene in mice causes deficits in sensorimotor gating and memory associated with hippocampal vacuolization. Zhou, X., Long, J.M., Geyer, M.A., Masliah, E., Kelsoe, J.R., Wynshaw-Boris, A., Chien, K.R. Mol. Psychiatry (2005)