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Chemical Compound Review

clotame     2-[(4-chloro-3-methyl- phenyl)amino]benzoic...

Synonyms: SureCN1649780, NINDS_000791, AC1L1KHV, AC1Q3RDV, LS-20482, ...
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Disease relevance of C12583


High impact information on C12583


Chemical compound and disease context of C12583


Biological context of C12583


Anatomical context of C12583

  • The present work was designed to study the pharmacological control of the receptor-mediated activation of human neutrophils by tolfenamic acid (2(-)[(3-chloro-2-methylphenyl)-amino]benzoic acid) [19].
  • Tolfenamic acid did not significantly alter 12-HETE generation or white blood cell accumulation in inflammatory exudate [16].
  • Tolfenamic acid was administered to beagle dogs at 2, 4 and 8 mg/kg bodyweight i.m. and the concentration of drug in plasma and in inflamed (administered carrageenan) and non-inflamed subcutaneous tissue cage fluid was measured [16].
  • The findings of this study are comparable to those of other studies and it is concluded that tolfenamic acid, in the relatively high dosage employed in this trial, is free from any irritant effect on the gastric mucosa [5].
  • Comparison of in vitro effects of flunixin and tolfenamic acid on human leukocyte and platelet functions [20].

Associations of C12583 with other chemical compounds


Gene context of C12583


Analytical, diagnostic and therapeutic context of C12583


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  3. Pharmacokinetics of tolfenamic acid in patients with cirrhosis of the liver. Stenderup, J., Eriksen, J., Pedersen, S.B., Christiansen, L.V. Eur. J. Clin. Pharmacol. (1985) [Pubmed]
  4. Pharmacokinetics of tolfenamic acid and its detection time in urine after intravenous administration of the drug in camels (Camelus dromedarius). Wasfi, I.A., ElGhazali, M., Hadi, A.A., Zorob, O., Boni, N.S., Alkatheeri, N.A., Barezaiq, I.M. Am. J. Vet. Res. (1998) [Pubmed]
  5. Comparative effects of tolfenamic acid and acetylsalicylic acid on human gastric mucosa. A double-blind crossover trial employing gastroscopy, extern gastrocamera and multiple biopsies. Axelsson, C.K., Christiansen, L.V., Johansen, A., Poulsen, P.E. Scand. J. Rheumatol. (1977) [Pubmed]
  6. Evidence of a cyclooxygenase-related prostaglandin synthesis in coral. The allene oxide pathway is not involved in prostaglandin biosynthesis. Varvas, K., Järving, I., Koljak, R., Valmsen, K., Brash, A.R., Samel, N. J. Biol. Chem. (1999) [Pubmed]
  7. Migrating motor complex of the intestine and absorption of a biliary excreted drug in the dog. Priymenko, N., Ferre, J.P., Rascol, A., Costes, G., Toutain, P.L. J. Pharmacol. Exp. Ther. (1993) [Pubmed]
  8. Hangover headache and prostaglandins: prophylactic treatment with tolfenamic acid. Kaivola, S., Parantainen, J., Osterman, T., Timonen, H. Cephalalgia : an international journal of headache. (1983) [Pubmed]
  9. Multi-residue liquid chromatography/tandem mass spectrometry method for the detection of non-steroidal anti-inflammatory drugs in bovine muscle: optimisation of ion trap parameters. Van Hoof, N., De Wasch, K., Poelmans, S., Noppe, H., De Brabander, H. Rapid Commun. Mass Spectrom. (2004) [Pubmed]
  10. Spectrofluorimetric determination of anthranilic acid derivatives based on terbium sensitized fluorescence. Ioannou, P.C., Rusakova, N.V., Andrikopoulou, D.A., Glynou, K.M., Tzompanaki, G.M. The Analyst. (1998) [Pubmed]
  11. Effects of migraine attack and metoclopramide on the absorption of tolfenamic acid. Tokola, R.A., Neuvonen, P.J. British journal of clinical pharmacology. (1984) [Pubmed]
  12. Tolfenamic acid rapid release versus sumatriptan in the acute treatment of migraine: comparable effect in a double-blind, randomized, controlled, parallel-group study. Myllylä, V.V., Havanka, H., Herrala, L., Kangasniemi, P., Rautakorpi, I., Turkka, J., Vapaatalo, H., Eskerod, O. Headache. (1998) [Pubmed]
  13. Prophylactic treatment of migraine with tolfenamic acid, propranolol and placebo. Mikkelsen, B., Pedersen, K.K., Christiansen, L.V. Acta neurologica Scandinavica. (1986) [Pubmed]
  14. Randomized double-blind comparison of tolfenamic acid and paracetamol in migraine. Larsen, B.H., Christiansen, L.V., Andersen, B., Olesen, J. Acta neurologica Scandinavica. (1990) [Pubmed]
  15. Geriatric pharmacology. Dowling, P.M. Vet. Clin. North Am. Small Anim. Pract. (2005) [Pubmed]
  16. Pharmacodynamics of tolfenamic acid in dogs. Evaluation of dose response relationships. McKellar, Q.A., Lees, P., Gettinby, G. Eur. J. Pharmacol. (1994) [Pubmed]
  17. Inhibition of prostaglandin biosynthesis by tolfenamic acid in vitro. Lindén, I.B., Parantainen, J., Vapaatalo, H. Scand. J. Rheumatol. (1976) [Pubmed]
  18. Protein binding of tolfenamic acid in the plasma from patients with renal and hepatic disease. Láznícek, M., Senius, K.E. Eur. J. Clin. Pharmacol. (1986) [Pubmed]
  19. Inhibition of human neutrophil function by tolfenamic acid involves inhibition of Ca2+ influx. Kankaanranta, H., Wuorela, H., Siltaloppi, E., Vuorinen, P., Vapaatalo, H., Moilanen, E. Eur. J. Pharmacol. (1995) [Pubmed]
  20. Comparison of in vitro effects of flunixin and tolfenamic acid on human leukocyte and platelet functions. Kankaanranta, H., Moilanen, E., Vapaatalo, H. Inflammation (1993) [Pubmed]
  21. Effect of diclofenac sodium, tolfenamic acid and indomethacin on the production of superoxide induced by N-formyl-methionyl-leucyl-phenylalanine in normal human polymorphonuclear leukocytes. Friman, C., Johnston, C., Chew, C., Davis, P. Scand. J. Rheumatol. (1986) [Pubmed]
  22. In vitro effects of nonsteroidal anti-inflammatory drugs on cyclooxygenase activity in dogs. Kay-Mugford, P., Benn, S.J., LaMarre, J., Conlon, P. Am. J. Vet. Res. (2000) [Pubmed]
  23. Infrared studies of the polymorphic states of the fenamates. Gilpin, R.K., Zhou, W. Journal of pharmaceutical and biomedical analysis. (2005) [Pubmed]
  24. Determination of expression of cyclooxygenase-1 and -2 isozymes in canine tissues and their differential sensitivity to nonsteroidal anti-inflammatory drugs. Wilson, J.E., Chandrasekharan, N.V., Westover, K.D., Eager, K.B., Simmons, D.L. Am. J. Vet. Res. (2004) [Pubmed]
  25. Tolfenamic acid and pancreatic cancer growth, angiogenesis, and Sp protein degradation. Abdelrahim, M., Baker, C.H., Abbruzzese, J.L., Safe, S. J. Natl. Cancer Inst. (2006) [Pubmed]
  26. Evaluation of selective inhibition of canine cyclooxygenase 1 and 2 by carprofen and other nonsteroidal anti-inflammatory drugs. Ricketts, A.P., Lundy, K.M., Seibel, S.B. Am. J. Vet. Res. (1998) [Pubmed]
  27. Tolfenamic acid inhibits leukotriene B4-induced chemotaxis of polymorphonuclear leukocytes in vitro. Kankaanranta, H., Moilanen, E., Vapaatalo, H. Inflammation (1991) [Pubmed]
  28. Anti-prostglandin therapy in prevention of side-effects of intrauterine contraceptive devices. Ylikorkala, O., Kauppila, A., Siljander, M. Lancet (1978) [Pubmed]
  29. Purification and 1H NMR spectroscopic characterization of phase II metabolites of tolfenamic acid. Sidelmann, U.G., Christiansen, E., Krogh, L., Cornett, C., Tjørnelund, J., Hansen, S.H. Drug Metab. Dispos. (1997) [Pubmed]
  30. Pharmacokinetics of tolfenamic acid: disposition in bile, blood and urine after intravenous administration to man. Pentikäinen, P.J., Tokola, O., Alhava, E., Penttilä, A. Eur. J. Clin. Pharmacol. (1984) [Pubmed]
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