Gene Review:
Psap - prosaposin
Mus musculus
Synonyms:
AI037048, Prosaposin, SGP-1, Sgp1, Sulfated glycoprotein 1
- Conditional expression of human acid {beta}-glucosidase improves the visceral phenotype in a Gaucher disease mouse model. Sun, Y., Quinn, B., Xu, Y.H., Leonova, T., Witte, D.P., Grabowski, G.A. J. Lipid Res. (2006)
- The trafficking of prosaposin (SGP-1) and GM2AP to the lysosomes of TM4 Sertoli cells is mediated by sortilin and monomeric adaptor proteins. Hassan, A.J., Zeng, J., Ni, X., Morales, C.R. Mol. Reprod. Dev. (2004)
- Prosaposin: threshold rescue and analysis of the "neuritogenic" region in transgenic mice. Sun, Y., Qi, X., Witte, D.P., Ponce, E., Kondoh, K., Quinn, B., Grabowski, G.A. Mol. Genet. Metab. (2002)
- Targeted disruption of the mouse prosaposin gene affects the development of the prostate gland and other male reproductive organs. Morales, C.R., Zhao, Q., El-Alfy, M., Suzuki, K. J. Androl. (2000)
- Procathepsin D interacts with prosaposin in cancer cells but its internalization is not mediated by LDL receptor-related protein. Laurent-Matha, V., Lucas, A., Huttler, S., Sandhoff, K., Garcia, M., Rochefort, H. Exp. Cell Res. (2002)
- Cell death prevention, mitogen-activated protein kinase stimulation, and increased sulfatide concentrations in Schwann cells and oligodendrocytes by prosaposin and prosaptides. Hiraiwa, M., Taylor, E.M., Campana, W.M., Darin, S.J., O'Brien, J.S. Proc. Natl. Acad. Sci. U.S.A. (1997)
- Identification of prosaposin as a neurotrophic factor. O'Brien, J.S., Carson, G.S., Seo, H.C., Hiraiwa, M., Kishimoto, Y. Proc. Natl. Acad. Sci. U.S.A. (1994)
- Saposin C promotes survival and prevents apoptosis via PI3K/Akt-dependent pathway in prostate cancer cells. Lee, T.J., Sartor, O., Luftig, R.B., Koochekpour, S. Mol. Cancer (2004)
- Genetic mapping of the mouse prosaposin gene (Psap) to mouse chromosome 10. Kozak, C.A., Adamson, M.C., Horowitz, M. Genomics (1994)
- Sphingolipid activator proteins are required for epidermal permeability barrier formation. Doering, T., Holleran, W.M., Potratz, A., Vielhaber, G., Elias, P.M., Suzuki, K., Sandhoff, K. J. Biol. Chem. (1999)
- Gaucher disease mouse models: point mutations at the acid beta-glucosidase locus combined with low-level prosaposin expression lead to disease variants. Sun, Y., Quinn, B., Witte, D.P., Grabowski, G.A. J. Lipid Res. (2005)
- The exon 8-containing prosaposin gene splice variant is dispensable for mouse development, lysosomal function, and secretion. Cohen, T., Auerbach, W., Ravid, L., Bodennec, J., Fein, A., Futerman, A.H., Joyner, A.L., Horowitz, M. Mol. Cell. Biol. (2005)
- Saposin C is required for normal resistance of acid beta-glucosidase to proteolytic degradation. Sun, Y., Qi, X., Grabowski, G.A. J. Biol. Chem. (2003)
- Study of the mouse sortilin gene: Effects of its transient silencing by RNA interference in TM4 Sertoli cells. Zeng, J., Hassan, A.J., Morales, C.R. Mol. Reprod. Dev. (2004)
- A mutation in the saposin A domain of the sphingolipid activator protein (prosaposin) gene results in a late-onset, chronic form of globoid cell leukodystrophy in the mouse. Matsuda, J., Vanier, M.T., Saito, Y., Tohyama, J., Suzuki, K., Suzuki, K. Hum. Mol. Genet. (2001)
- In vivo roles of RORalpha and Sp4 in the regulation of murine prosaposin gene. Jin, P., Sun, Y., Grabowski, G.A. DNA Cell Biol. (2001)
- Identification of a novel sequence involved in lysosomal sorting of the sphingolipid activator protein prosaposin. Zhao, Q., Morales, C.R. J. Biol. Chem. (2000)
- Structural analysis of the mouse prosaposin (SGP-1) gene reveals the presence of an exon that is alternatively spliced in transcribed mRNAs. Zhao, Q., Hay, N., Morales, C.R. Mol. Reprod. Dev. (1997)
- Developmental and tissue-specific expression of prosaposin mRNA in murine tissues. Sun, Y., Witte, D.P., Grabowski, G.A. Am. J. Pathol. (1994)
- Murine prosaposin: expression in the reproductive system of a gene implicated in human genetic diseases. Sprecher-Levy, H., Orr-Urtreger, A., Lonai, P., Horowitz, M. Cell. Mol. Biol. (Noisy-le-grand) (1993)
- Structural requirements for lysosomal targeting of the prosaposin precursor protein. Ham, D. Cell Biol. Int. (2003)