Disease relevance of ORAOV1

• The data suggest that TAOS1 may be an amplification-dependent candidate oncogene with a role in the development and/or progression of human tumors, including oral squamous cell carcinomas [1].
• High-resolution mapping of the 11q13 amplicon and identification of a gene, TAOS1, that is amplified and overexpressed in oral cancer cells [1].
• The examination of the correlation of TAOS1 overexpression with the clinicopathological features revealed a significant difference in lymph node metastasis (p = 0.014) and a trend towards advanced TNM stages (p = 0.074) [2].
• Fluorescence imaging and its applications, ranging from nano-bioscience to small-animal imaging and imaging of disease progression in humans, were the main topics, with opportunities for further discussion in the cantinas of the town and on the ski slopes of Taos mountain [3].

High impact information on ORAOV1

• We have analyzed one of these expressed sequence tag clusters and now report that it contains a previously uncharacterized gene, TAOS1 (tumor amplified and overexpressed sequence 1), which is both amplified and overexpressed in oral cancer cells [1].
• The 3rd such meeting, held 8-11 September 2000 in Taos, New Mexico, covered research on technologies for SNP scoring, analytical tools for using SNPs to map disease genes, examples from researchers using SNPs for specific disease studies, and databases and tools for facilitating these activities [4].
• Tris(dimethylamino)oxosulfonium difluorotrimethylsilicate, (Me(2)N)(3)SO(+)Me(3)SiF(2)(-) (TAOS Fluoride) [5].
• MATERIALS AND METHODS: Quantitative RT-PCR was performed to determine the possible relationship between TAOS1 gene expression levels and clinicopathological features in esophageal SCC [2].
• Keystone symposium. Melanoma and biology of the neural crest. Taos City Hall, Taos, New Mexico, USA, 1-8 February 1992 [6].

Biological context of ORAOV1

• Suppressing times. Negative Controls on Cell Growth: a UCLA symposium, sponsored by ICI Pharmaceuticals and Smith Kline and French, Taos, NM, USA, March 3-9, 1990 [7].
• RNA today. Molecular Evolution of Introns and Other RNA Elements: a Keystone Symposium, Taos, NM, USA, February 2-8, 1991 [8].
• Replication, recombination, and red chilli amidst the Pueblos. Molecular mechanisms in DNA replication and recombination. A U.S. Biochemical Corporation Keystone symposia, Taos, New Mexico, January 25 to February 1, 1992 [9].

Other interactions of ORAOV1

• This region contained several genes previously shown to be amplified and overexpressed in HNSCC, including CCDN1, CTTN, SHANK2, and ORAOV1 [10].

References