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Gene Review:

Rsph1 - radial spoke head 1 homolog (Chlamydomonas)

Mus musculus

Synonyms: MCA, Male meiotic metaphase chromosome-associated acidic protein, Meichroacidin, Radial spoke head 1 homolog, Testis-specific gene A2 protein, ...

Ju, T.K. et al., Tsuchida, J. et al., Hui, L. et al.

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High impact information on Tsga2

The highly regulated stage-specific expression of meichroacidin and its specific association with the metaphase chromosomes and spindles suggest that the protein plays important roles in male meiosis [1].
Surprisingly, these TSGA2 isoforms appear to localize in the vicinity of the anterior acrosome, as well, suggesting that Tsga2 may also play a role in sperm-egg interaction [2].
Carp MSAP is exclusively transcribed in testis, while mouse meichroacidin message is present in gonads of both sexes, although especially enriched in testis [3].
In mouse, meichroacidin is expressed in male germ cells of meiotic stages, while carp MSAP is expressed during late spermiogenesis and accumulated in mature spermatozoa, in which MSAP is localized to the basal body and flagellum [3].

Analytical, diagnostic and therapeutic context of Tsga2

Molecular cloning and characterization of meichroacidin (male meiotic metaphase chromosome-associated acidic protein) [1].

References

Molecular cloning and characterization of meichroacidin (male meiotic metaphase chromosome-associated acidic protein). Tsuchida, J., Nishina, Y., Wakabayashi, N., Nozaki, M., Sakai, Y., Nishimune, Y. Dev. Biol. (1998) [Pubmed]
The mouse T complex gene Tsga2, encoding polypeptides located in the sperm tail and anterior acrosome, maps to a locus associated with sperm motility and sperm-egg interaction abnormalities. Hui, L., Lu, J., Han, Y., Pilder, S.H. Biol. Reprod. (2006) [Pubmed]
MSAP, the meichroacidin homolog of carp (Cyprinus carpio), differs from the rodent counterpart in germline expression and involves flagellar differentiation. Ju, T.K., Huang, F.L. Biol. Reprod. (2004) [Pubmed]

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RSPH1	Bos taurus
RSPH1	Canis lupus familiaris
im:6909388	Danio rerio
RSPH1	Gallus gallus
RSPH1	Homo sapiens
RSPH1	Macaca mulatta
RSPH1	Pan troglodytes
Rsph1	Rattus norvegicus
LOC100489385	Xenopus (Silurana) tropicalis

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