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Gene Review

OPN5  -  opsin 5

Homo sapiens

Synonyms: G-protein coupled receptor 136, G-protein coupled receptor PGR12, GPR136, GRP136, Neuropsin, ...
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Disease relevance of OPN5


High impact information on OPN5

  • Human kallikrein 8 (hK8; neuropsin) is a serine protease and new member of the hK family [3].
  • All splice junctions follow the GT/AG rule, and the intron phases are identical to those of many other genes belonging to the same family, i.e., the kallikreins, NES1, and neuropsin [4].
  • Here we have cloned a cDNA and analyzed the gene for human neuropsin by polymerase chain reaction-based strategies [5].
  • The gene for human neuropsin had six exons and five introns, and the gene organization is similar to trypsin-type serine proteases [5].
  • The amino acid sequences of the two types of human neuropsin were identical, except that type 2 carried an insert of 45 amino acids at the C-terminus of the leader sequence [6].

Biological context of OPN5


Anatomical context of OPN5


Other interactions of OPN5


Analytical, diagnostic and therapeutic context of OPN5


  1. The human KLK8 (neuropsin/ovasin) gene: identification of two novel splice variants and its prognostic value in ovarian cancer. Magklara, A., Scorilas, A., Katsaros, D., Massobrio, M., Yousef, G.M., Fracchioli, S., Danese, S., Diamandis, E.P. Clin. Cancer Res. (2001) [Pubmed]
  2. Association of the progesterone receptor gene with breast cancer risk: a single-nucleotide polymorphism tagging approach. Pooley, K.A., Healey, C.S., Smith, P.L., Pharoah, P.D., Thompson, D., Tee, L., West, J., Jordan, C., Easton, D.F., Ponder, B.A., Dunning, A.M. Cancer Epidemiol. Biomarkers Prev. (2006) [Pubmed]
  3. Human kallikrein 8, a novel biomarker for ovarian carcinoma. Kishi, T., Grass, L., Soosaipillai, A., Scorilas, A., Harbeck, N., Schmalfeldt, B., Dorn, J., Mysliwiec, M., Schmitt, M., Diamandis, E.P. Cancer Res. (2003) [Pubmed]
  4. Molecular characterization of zyme/protease M/neurosin (PRSS9), a hormonally regulated kallikrein-like serine protease. Yousef, G.M., Luo, L.Y., Scherer, S.W., Sotiropoulou, G., Diamandis, E.P. Genomics (1999) [Pubmed]
  5. Sequence analysis and expression of human neuropsin cDNA and gene. Yoshida, S., Taniguchi, M., Hirata, A., Shiosaka, S. Gene (1998) [Pubmed]
  6. A novel form of human neuropsin, a brain-related serine protease, is generated by alternative splicing and is expressed preferentially in human adult brain. Mitsui, S., Tsuruoka, N., Yamashiro, K., Nakazato, H., Yamaguchi, N. Eur. J. Biochem. (1999) [Pubmed]
  7. Expression of the kallikrein gene family in normal and Alzheimer's disease brain. Shimizu-Okabe, C., Yousef, G.M., Diamandis, E.P., Yoshida, S., Shiosaka, S., Fahnestock, M. Neuroreport (2001) [Pubmed]
  8. Plasticity-related serine proteases in the brain (review). Yoshida, S., Shiosaka, S. Int. J. Mol. Med. (1999) [Pubmed]
  9. Role of kallikrein enzymes in the central nervous system. Yousef, G.M., Kishi, T., Diamandis, E.P. Clin. Chim. Acta (2003) [Pubmed]
  10. Proteases involved in long-term potentiation. Tomimatsu, Y., Idemoto, S., Moriguchi, S., Watanabe, S., Nakanishi, H. Life Sci. (2002) [Pubmed]
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