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Gene Review

KLK10  -  kallikrein-related peptidase 10

Homo sapiens

Synonyms: Kallikrein-10, NES1, Normal epithelial cell-specific 1, PRSSL1, Protease serine-like 1
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Disease relevance of KLK10


Psychiatry related information on KLK10

  • Dependent variables included four subtests from NES1 (tapping, reaction time, pattern comparison, and Benton visual retention), as well as VEP-latencies (N2, P100, N3) evoked by checkerboard patterns of different size and contrast [5].

High impact information on KLK10

  • The serum concentration of human kallikrein 10 represents a novel biomarker for ovarian cancer diagnosis and prognosis [6].
  • Using methylation-specific PCR and sequence analysis of sodium bisulfite-treated genomic DNA, we demonstrate a strong correlation between exon 3 hypermethylation and loss of NES1 mRNA expression in a panel of breast cancer cell lines and in primary tumors [7].
  • We suggest that hypermethylation is responsible for tumor-specific loss of NES1 gene expression [7].
  • Using a luciferase reporter system, we demonstrate that most tumor cell lines are able to support full or partial transcription from the NES1 promoter, suggesting a role for promoter-independent cis-acting mechanisms of loss of NES1 expression [7].
  • Now, we have cloned and characterized the active promoter region of NES1 [7].

Chemical compound and disease context of KLK10


Biological context of KLK10


Anatomical context of KLK10


Associations of KLK10 with chemical compounds


Other interactions of KLK10


Analytical, diagnostic and therapeutic context of KLK10


  1. Overexpression of kallikrein 10 in epithelial ovarian carcinomas. Shvartsman, H.S., Lu, K.H., Lee, J., Lillie, J., Deavers, M.T., Clifford, S., Wolf, J.K., Mills, G.B., Bast, R.C., Gershenson, D.M., Schmandt, R. Gynecol. Oncol. (2003) [Pubmed]
  2. The new human kallikrein gene family: implications in carcinogenesis. Diamandis, E.P., Yousef, G.M., Luo, L.Y., Magklara, A., Obiezu, C.V. Trends Endocrinol. Metab. (2000) [Pubmed]
  3. Expression of the human kallikrein genes 10 (KLK10) and 11 (KLK11) in cancerous and non-cancerous lung tissues. Planque, C., Aïnciburu, M., Heuzé-Vourc'h, N., Régina, S., de Monte, M., Courty, Y. Biol. Chem. (2006) [Pubmed]
  4. Identification of new splice variants and differential expression of the human kallikrein 10 gene, a candidate cancer biomarker. Yousef, G.M., White, N.M., Michael, I.P., Cho, J.C., Robb, J.D., Kurlender, L., Khan, S., Diamandis, E.P. Tumour Biol. (2005) [Pubmed]
  5. Neurobehavioral and neurophysiological observations in six year old children with low lead levels in East and West Germany. Winneke, G., Altmann, L., Krämer, U., Turfeld, M., Behler, R., Gutsmuths, F.J., Mangold, M. Neurotoxicology (1994) [Pubmed]
  6. The serum concentration of human kallikrein 10 represents a novel biomarker for ovarian cancer diagnosis and prognosis. Luo, L.Y., Katsaros, D., Scorilas, A., Fracchioli, S., Bellino, R., van Gramberen, M., de Bruijn, H., Henrik, A., Stenman, U.H., Massobrio, M., van der Zee, A.G., Vergote, I., Diamandis, E.P. Cancer Res. (2003) [Pubmed]
  7. CpG methylation as a basis for breast tumor-specific loss of NES1/kallikrein 10 expression. Li, B., Goyal, J., Dhar, S., Dimri, G., Evron, E., Sukumar, S., Wazer, D.E., Band, V. Cancer Res. (2001) [Pubmed]
  8. Steroid hormone regulation of the human kallikrein 10 (KLK10) gene in cancer cell lines and functional characterization of the KLK10 gene promoter. Luo, L.Y., Grass, L., Diamandis, E.P. Clin. Chim. Acta (2003) [Pubmed]
  9. Higher expression of human kallikrein 10 in breast cancer tissue predicts tamoxifen resistance. Luo, L.Y., Diamandis, E.P., Look, M.P., Soosaipillai, A.P., Foekens, J.A. Br. J. Cancer (2002) [Pubmed]
  10. The normal epithelial cell-specific 1 (NES1) gene is up-regulated by steroid hormones in the breast carcinoma cell line BT-474. Luo, L.Y., Grass, L., Diamandis, E.P. Anticancer Res. (2000) [Pubmed]
  11. Identification of single nucleotide polymorphisms in the human kallikrein 10 (KLK10) gene and their association with prostate, breast, testicular, and ovarian cancers. Bharaj, B.B., Luo, L.Y., Jung, K., Stephan, C., Diamandis, E.P. Prostate (2002) [Pubmed]
  12. Downregulation of human kallikrein 10 (KLK10/NES1) by CpG island hypermethylation in breast, ovarian and prostate cancers. Sidiropoulos, M., Pampalakis, G., Sotiropoulou, G., Katsaros, D., Diamandis, E.P. Tumour Biol. (2005) [Pubmed]
  13. Clinical significance of human kallikrein 10 gene expression in colorectal cancer and gastric cancer. Feng, B., Xu, W.B., Zheng, M.H., Ma, J.J., Cai, Q., Zhang, Y., Ji, J., Lu, A.G., Qu, Y., Li, J.W., Wang, M.L., Hu, W.G., Liu, B.Y., Zhu, Z.G. J. Gastroenterol. Hepatol. (2006) [Pubmed]
  14. Identification of a novel serine protease-like gene, the expression of which is down-regulated during breast cancer progression. Liu, X.L., Wazer, D.E., Watanabe, K., Band, V. Cancer Res. (1996) [Pubmed]
  15. Immunofluorometric assay of human kallikrein 10 and its identification in biological fluids and tissues. Luo, L.Y., Grass, L., Howarth, D.J., Thibault, P., Ong, H., Diamandis, E.P. Clin. Chem. (2001) [Pubmed]
  16. Molecular characterization of zyme/protease M/neurosin (PRSS9), a hormonally regulated kallikrein-like serine protease. Yousef, G.M., Luo, L.Y., Scherer, S.W., Sotiropoulou, G., Diamandis, E.P. Genomics (1999) [Pubmed]
  17. In-silico analysis of kallikrein gene expression in pancreatic and colon cancers. Yousef, G.M., Borgoño, C.A., Popalis, C., Yacoub, G.M., Polymeris, M.E., Soosaipillai, A., Diamandis, E.P. Anticancer Res. (2004) [Pubmed]
  18. Structural characterization and mapping of the normal epithelial cell-specific 1 gene. Luo, L., Herbrick, J.A., Scherer, S.W., Beatty, B., Squire, J., Diamandis, E.P. Biochem. Biophys. Res. Commun. (1998) [Pubmed]
  19. Human kallikrein 10 expression in normal tissues by immunohistochemistry. Petraki, C.D., Karavana, V.N., Luo, L.Y., Diamandis, E.P. J. Histochem. Cytochem. (2002) [Pubmed]
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