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Gene Review:

Vpreb1 - pre-B lymphocyte gene 1

Mus musculus

Synonyms: CD179a, Immunoglobulin iota chain, Protein VPreB1, Vpreb-1

Donohoe, M.E. et al., Abramson, C.S. et al., Bernards, A. et al., Palacios, R. et al., Okabe, T. et al., et al.

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Disease relevance of Vpreb1

NALM-6-M1 is an acute lymphoblastic leukemia cell line previously shown in our laboratory to express the pre-B lymphocyte phenotype, i.e., cytoplasmic IgM+, surface immunoglobulin-. Hybridomas were produced against this cell line by fusing spleen cells from hyperimmunized mice with NS-1 mouse myeloma cells [1].
Cell lines examined included a T lymphoma, a pre-B lymphocyte, and a non-B-non-T tumor cell line, as well as an Ig-nonproducing myeloma of undetermined differentiated status [2].

High impact information on Vpreb1

A complex of glycoproteins (200, 130, 105, and 65-35 kD) was identified as coprecipitated with the Vpreb/lamba 5 surrogate L chain in mu H chain-negative precursor B cell lines [3].
Ltk is expressed at a very low level in only a few cell lines and tissues and may be the receptor for a pre-B lymphocyte growth or differentiation factor, because 10 tested pre-B lines each contained 2.4 and 2.8 kb mRNAs [4].
Interleukin-7 (IL-7) is a potent stimulator of pre-B-lymphocyte proliferation [5].
Finally, we found that the hu lambda 5 transgene is able to rescue the pre-B lymphocyte block when bred onto the m lambda 5-/- background [6].
Pre-B lymphocyte-specific transcriptional control of the mouse VpreB gene [7].

Biological context of Vpreb1

The Vpreb1 and comt genes are closely linked and sublocalized to rat chromosome 11q23 [8].
The role of polycyclic aromatic hydrocarbon metabolism in dimethylbenz[a]anthracene-induced pre-B lymphocyte apoptosis [9].

Anatomical context of Vpreb1

Fetal liver pro-B and pre-B lymphocyte clones: expression of lymphoid-specific genes, surface markers, growth requirements, colonization of the bone marrow, and generation of B lymphocytes in vivo and in vitro [10].

Regulatory relationships of Vpreb1

The VpreB1 protein is thought to be expressed on the surface of pre-B cells in association with lambda 5 and mu heavy chain, and to play an important role on B cell differentiation [11].

Other interactions of Vpreb1

Therefore, we conclude that the hu lambda 5 polypeptide can biochemically and functionally substitute for m lambda 5 in vivo in pre-B lymphocyte differentiation and proliferation [6].
Severe B-cell maturation arrest was observed in rae28-/- between pro- and pre-B lymphocyte stages [12].

References

A monoclonal antibody (BA-1) reactive with cells of human B lymphocyte lineage. Abramson, C.S., Kersey, J.H., LeBien, T.W. J. Immunol. (1981) [Pubmed]
Murine plasmacytomas constitute a class of natural heat-shock variants in which the major inducible hsp-68 gene is not expressed. Aujame, L. Can. J. Genet. Cytol. (1986) [Pubmed]
A complex of glycoproteins is associated with VpreB/lambda 5 surrogate light chain on the surface of mu heavy chain-negative early precursor B cell lines. Karasuyama, H., Rolink, A., Melchers, F. J. Exp. Med. (1993) [Pubmed]
The ltk receptor tyrosine kinase is expressed in pre-B lymphocytes and cerebral neurons and uses a non-AUG translational initiator. Bernards, A., de la Monte, S.M. EMBO J. (1990) [Pubmed]
Hyperexpression of interleukin-7 is not necessary or sufficient for transformation of a pre-B lymphoid cell line. Young, J.C., Gishizky, M.L., Witte, O.N. Mol. Cell. Biol. (1991) [Pubmed]
Transgenic human lambda 5 rescues the murine lambda 5 nullizygous phenotype. Donohoe, M.E., Beck-Engeser, G.B., Lonberg, N., Karasuyama, H., Riley, R.L., Jäck, H.M., Blomberg, B.B. J. Immunol. (2000) [Pubmed]
Pre-B lymphocyte-specific transcriptional control of the mouse VpreB gene. Okabe, T., Bauer, S.R., Kudo, A. Eur. J. Immunol. (1992) [Pubmed]
The Vpreb1 and comt genes are closely linked and sublocalized to rat chromosome 11q23. Yeung, R.S., Bell, D.W., Testa, J.R. Mamm. Genome (1996) [Pubmed]
The role of polycyclic aromatic hydrocarbon metabolism in dimethylbenz[a]anthracene-induced pre-B lymphocyte apoptosis. Mann, K.K., Matulka, R.A., Hahn, M.E., Trombino, A.F., Lawrence, B.P., Kerkvliet, N.I., Sherr, D.H. Toxicol. Appl. Pharmacol. (1999) [Pubmed]
Fetal liver pro-B and pre-B lymphocyte clones: expression of lymphoid-specific genes, surface markers, growth requirements, colonization of the bone marrow, and generation of B lymphocytes in vivo and in vitro. Palacios, R., Samaridis, J. Mol. Cell. Biol. (1992) [Pubmed]
A pre-B- and B cell-specific DNA-binding protein, EBB-1, which binds to the promoter of the VpreB1 gene. Okabe, T., Watanabe, T., Kudo, A. Eur. J. Immunol. (1992) [Pubmed]
Lack of the Polycomb-group gene rae28 causes maturation arrest at the early B-cell developmental stage. Tokimasa, S., Ohta, H., Sawada, A., Matsuda, Y., Kim, J.Y., Nishiguchi, S., Hara, J., Takihara, Y. Exp. Hematol. (2001) [Pubmed]

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VPREB1	Canis lupus familiaris
VPREB1	Homo sapiens
VPREB1	Macaca mulatta
Vpreb2	Mus musculus
LOC458686	Pan troglodytes
Vpreb1	Rattus norvegicus
Vpreb2	Rattus norvegicus

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