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Gene Review

Vpreb1  -  pre-B lymphocyte gene 1

Mus musculus

Synonyms: CD179a, Immunoglobulin iota chain, Protein VPreB1, Vpreb-1
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Disease relevance of Vpreb1


High impact information on Vpreb1


Biological context of Vpreb1


Anatomical context of Vpreb1


Regulatory relationships of Vpreb1

  • The VpreB1 protein is thought to be expressed on the surface of pre-B cells in association with lambda 5 and mu heavy chain, and to play an important role on B cell differentiation [11].

Other interactions of Vpreb1


  1. A monoclonal antibody (BA-1) reactive with cells of human B lymphocyte lineage. Abramson, C.S., Kersey, J.H., LeBien, T.W. J. Immunol. (1981) [Pubmed]
  2. Murine plasmacytomas constitute a class of natural heat-shock variants in which the major inducible hsp-68 gene is not expressed. Aujame, L. Can. J. Genet. Cytol. (1986) [Pubmed]
  3. A complex of glycoproteins is associated with VpreB/lambda 5 surrogate light chain on the surface of mu heavy chain-negative early precursor B cell lines. Karasuyama, H., Rolink, A., Melchers, F. J. Exp. Med. (1993) [Pubmed]
  4. The ltk receptor tyrosine kinase is expressed in pre-B lymphocytes and cerebral neurons and uses a non-AUG translational initiator. Bernards, A., de la Monte, S.M. EMBO J. (1990) [Pubmed]
  5. Hyperexpression of interleukin-7 is not necessary or sufficient for transformation of a pre-B lymphoid cell line. Young, J.C., Gishizky, M.L., Witte, O.N. Mol. Cell. Biol. (1991) [Pubmed]
  6. Transgenic human lambda 5 rescues the murine lambda 5 nullizygous phenotype. Donohoe, M.E., Beck-Engeser, G.B., Lonberg, N., Karasuyama, H., Riley, R.L., Jäck, H.M., Blomberg, B.B. J. Immunol. (2000) [Pubmed]
  7. Pre-B lymphocyte-specific transcriptional control of the mouse VpreB gene. Okabe, T., Bauer, S.R., Kudo, A. Eur. J. Immunol. (1992) [Pubmed]
  8. The Vpreb1 and comt genes are closely linked and sublocalized to rat chromosome 11q23. Yeung, R.S., Bell, D.W., Testa, J.R. Mamm. Genome (1996) [Pubmed]
  9. The role of polycyclic aromatic hydrocarbon metabolism in dimethylbenz[a]anthracene-induced pre-B lymphocyte apoptosis. Mann, K.K., Matulka, R.A., Hahn, M.E., Trombino, A.F., Lawrence, B.P., Kerkvliet, N.I., Sherr, D.H. Toxicol. Appl. Pharmacol. (1999) [Pubmed]
  10. Fetal liver pro-B and pre-B lymphocyte clones: expression of lymphoid-specific genes, surface markers, growth requirements, colonization of the bone marrow, and generation of B lymphocytes in vivo and in vitro. Palacios, R., Samaridis, J. Mol. Cell. Biol. (1992) [Pubmed]
  11. A pre-B- and B cell-specific DNA-binding protein, EBB-1, which binds to the promoter of the VpreB1 gene. Okabe, T., Watanabe, T., Kudo, A. Eur. J. Immunol. (1992) [Pubmed]
  12. Lack of the Polycomb-group gene rae28 causes maturation arrest at the early B-cell developmental stage. Tokimasa, S., Ohta, H., Sawada, A., Matsuda, Y., Kim, J.Y., Nishiguchi, S., Hara, J., Takihara, Y. Exp. Hematol. (2001) [Pubmed]
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