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Gene Review:

Oscar - osteoclast associated receptor

Mus musculus

Synonyms: Ocl178, Osteoclast-associated immunoglobulin-like receptor, Osteoclast-associated receptor, mOSCAR, mOSCAR-M1, ...

So, H. et al., Kim, Y. et al., Kim, N. et al., Ishikawa, S. et al., Kim, K. et al., et al.

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Disease relevance of Oscar

PTH, IL-6, and antibodies against osteoclast-associated receptor did not affect bone resorption [1].

High impact information on Oscar

Here we report the identification and characterization of OC-associated receptor (OSCAR), a novel member of the leukocyte receptor complex (LRC)-encoded family expressed specifically in OCs [2].
Moreover, addition of a soluble form of OSCAR in coculture with osteoblasts inhibits the formation of OCs from bone marrow precursor cells in the presence of bone-resorbing factors, indicating that OSCAR may be an important bone-specific regulator of OC differentiation [2].
Overexpression of Id2 in BMMs attenuates the gene induction of nuclear factor of activated T cells c1 (NFATc1) and osteoclast-associated receptor (OSCAR) during TRANCE-mediated osteoclastogenesis [3].
Thus, OSCAR but not TREM-2 is involved in the positive feedback loop of the immunoreceptor-NFATc1 pathway during osteoclastogenesis [4].
Nuclear factor of activated T cells c1 induces osteoclast-associated receptor gene expression during tumor necrosis factor-related activation-induced cytokine-mediated osteoclastogenesis [5].

Biological context of Oscar

Here, we have cloned the OSCAR promoter region to examine its regulation by transcription factors [6].
In addition, we have shown that the combination of MITF and constitutively active MKK6-expressing plasmids synergistically activates OSCAR reporter activity [6].
The 1.7-kb promoter region of the mouse OSCAR gene contains two potential E-box elements for microphthalmia transcription factor (MITF) and three putative PU.1 sites [6].
Furthermore, FcRgamma is required for signal transduction by OSCAR [7].
During osteoclast differentiation, NFATc1 is further activated via calcium signaling when costimulatory receptors expressed on osteoclast precursors, such as osteoclast-associated receptor (OSCAR), are stimulated [5].

Anatomical context of Oscar

Contribution of nuclear factor of activated T cells c1 to the transcriptional control of immunoreceptor osteoclast-associated receptor but not triggering receptor expressed by myeloid cells-2 during osteoclastogenesis [4].
We have recently reported the identification of a novel member of the leukocyte receptor family, osteoclast-associated receptor (OSCAR), which has two Ig-like domains and functions as a bone-specific regulator of osteoclast differentiation [6].
Microphthalmia transcription factor and PU.1 synergistically induce the leukocyte receptor osteoclast-associated receptor gene expression [6].

Other interactions of Oscar

Here, we found that the FcRgamma chain, a signal transducing adaptor molecule for Fc receptors, is associated with OSCAR and is involved in the cell surface expression of OSCAR [7].

References

Murine osteoclast formation and function: differential regulation by humoral agents. Fuller, K., Kirstein, B., Chambers, T.J. Endocrinology (2006) [Pubmed]
A novel member of the leukocyte receptor complex regulates osteoclast differentiation. Kim, N., Takami, M., Rho, J., Josien, R., Choi, Y. J. Exp. Med. (2002) [Pubmed]
Id helix-loop-helix proteins negatively regulate TRANCE-mediated osteoclast differentiation. Lee, J., Kim, K., Kim, J.H., Jin, H.M., Choi, H.K., Lee, S.H., Kook, H., Kim, K.K., Yokota, Y., Lee, S.Y., Choi, Y., Kim, N. Blood (2006) [Pubmed]
Contribution of nuclear factor of activated T cells c1 to the transcriptional control of immunoreceptor osteoclast-associated receptor but not triggering receptor expressed by myeloid cells-2 during osteoclastogenesis. Kim, Y., Sato, K., Asagiri, M., Morita, I., Soma, K., Takayanagi, H. J. Biol. Chem. (2005) [Pubmed]
Nuclear factor of activated T cells c1 induces osteoclast-associated receptor gene expression during tumor necrosis factor-related activation-induced cytokine-mediated osteoclastogenesis. Kim, K., Kim, J.H., Lee, J., Jin, H.M., Lee, S.H., Fisher, D.E., Kook, H., Kim, K.K., Choi, Y., Kim, N. J. Biol. Chem. (2005) [Pubmed]
Microphthalmia transcription factor and PU.1 synergistically induce the leukocyte receptor osteoclast-associated receptor gene expression. So, H., Rho, J., Jeong, D., Park, R., Fisher, D.E., Ostrowski, M.C., Choi, Y., Kim, N. J. Biol. Chem. (2003) [Pubmed]
Involvement of FcRgamma in signal transduction of osteoclast-associated receptor (OSCAR). Ishikawa, S., Arase, N., Suenaga, T., Saita, Y., Noda, M., Kuriyama, T., Arase, H., Saito, T. Int. Immunol. (2004) [Pubmed]

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