Disease relevance of OSCAR

• OSCAR costa-mandry and posthurricane bacillary dysentery [1].
• We carried out an independent evaluation of the OSCAR 2 oscillometric ambulatory blood pressure monitor (SunTech Medical model 222) according to the European Society of Hypertension International Protocol [2].
• Prevalence rate of pressure ulcers in California nursing homes: using the OSCAR database to develop a risk-adjustment model [3].
• The physiological and behavioural responses of two size groups of oscar (Astronotus ocellatus) to hypoxia were studied [4].
• Oscar Wilde's skin disease: allergic contact dermatitis [5]?

Psychiatry related information on OSCAR

• Such a "blooming, buzzing confusion" of internal and external referents might appear to be psychotic and imply a loss of "reality testing." Chassaguet-Smirgel (1988), citing Oscar Wilde's The Picture of Dorian Gray as an example, contended that the artist narrowly averts psychosis by transforming it into a work of art [6].

High impact information on OSCAR

• Here we show that ligation of hOSCAR by specific antibodies promotes dendritic cell (DC) survival by an extracellular signal-regulated kinase (ERK)- and phosphatidylinositol 3-kinase (PI3K)-dependent pathway, linked to expression of the Bcl-2 and Bcl-x(L) antiapoptotic molecules [7].
• Fc receptor gamma-chain activation via hOSCAR induces survival and maturation of dendritic cells and modulates Toll-like receptor responses [7].
• The percentage of interferon (IFN)-gamma-producing T cells is decreased when hOSCAR engagement is combined with LPS stimulation [7].
• We previously reported the characterization of human osteoclast-associated receptor (hOSCAR), a novel Fc receptor gamma-chain (FcRgamma)-associated receptor expressed by myeloid cells [7].
• Stimulation of hOSCAR acts in conjunction with the Toll-like receptor (TLR) ligands, lipopolysaccharide (LPS), R-848, and polyinosinic-polycytidylic acid (poly(I:C)), to increase the expression of maturation markers, and to modulate cytokine release [7].

Chemical compound and disease context of OSCAR

• In this second in a series of famous historic personages who suffered from ear disease (see Yardley M, Rutka J. Troy, Mycenae, and the Otologic Demise of Herr Heinrich Schliemann. J Otolaryngol 1998; 27:217-221), we review the life and otology-related death of the legendary playwright Oscar Wilde [8].

Biological context of OSCAR

• OSCAR is an FcRgamma-associated receptor that is expressed by myeloid cells and is involved in antigen presentation and activation of human dendritic cells [9].
• In an effort to identify genetic polymorphisms in potential candidate genes for osteoporosis, 10 variants were identified in the OSCAR gene using direct DNA sequencing, and 560 postmenopausal women were genotyped at five SNP loci, using the TaqMan method [10].
• Finally, because hOSCAR prevents apoptosis of DCs in the absence of growth/survival factors, CD85j cross-linking was able to counteract completely this antiapoptotic effect and to reduce Bcl-2 expression enhanced by hOSCAR stimulation [11].
• OBJECTIVE: This study was undertaken to evaluate the performance of a 1-stop clinic for first-trimester assessment of risk (OSCAR) for trisomy 21 by a combination of maternal age, fetal nuchal translucency (NT) thickness, and maternal serum-free ss- human chorionic gonadotrophin (hCG) and pregnancy-associated plasma protein-A (PAPP-A) [12].
• STUDY DESIGN: OSCAR was carried out in 30,564 pregnancies at 11 to 13 + 6 weeks [12].

Anatomical context of OSCAR

• CD85j and hOSCAR were expressed consistently at the same density on monocytes and on monocyte-derived DCs (both immature and mature) [11].
• CD85j (leukocyte Ig-like receptor-1/Ig-like transcript 2) inhibits human osteoclast-associated receptor-mediated activation of human dendritic cells [11].
• Inhibition of DCs via CD85j also impaired their ability to enhance Ag-specific T cell proliferation induced by hOSCAR [11].
• Immature dendritic cells (DCs) derived from freshly isolated human monocytes were used to evaluate the effect of the inhibiting receptor CD85j (leukocyte Ig-like receptor-1/ILT2) on activation induced by cross-linking of the human osteoclast-associated receptor (hOSCAR) [11].
• Overall, our data demonstrate that hOSCAR is a functional receptor on monocytes and neutrophils, involved in the induction of the primary proinflammatory cascade and the initiation of downstream immune responses [13].

Associations of OSCAR with chemical compounds

• Cross-linking of hOSCAR, which activates via the FcR-associated gamma-chain, induced Ca(2+) flux in DCs [11].
• Low level cadmium exposure, renal and bone effects--the OSCAR study [14].
• According to two of the models--the Phonological Loop model (Hitch, Burgess, Towse, & Culpin, 1996) and the OSCAR model (Brown, Preece, & Hulme, 2000)--contextual information depends critically on the timing of item presentation with reference to group onset [15].
• The OSCAR-project (Optimal Speech Communication Assistance for Residual Abilities) within the TIDE frame is aiming at processing the speech signal in such a way so that it can be more effectively aurally perceived than with an ordinary hearing aid in case of a very small residual hearing [16].
• The 2,3-BPG effect in rHb Oscar also appears to be slightly enhanced compared to that in Hb A [17].
• OSCAR was expressed by osteoclasts at the erosion front and by mononuclear cells around synovial microvessels [18].

Other interactions of OSCAR

• We measured the expression of ERM gene, a nuclear transcription factor belonging to the ets family, in a series of 364 unselected primary breast cancers from patients who underwent locoregional surgery in the Centre Oscar Lambret between May 1989 and December 1991 [19].
• Thymosin beta 12 also shows 84% sequence homology to thymosin beta 11, a beta 4 analog which replaces beta 4 in two species of bony fish, oscar and rainbow trout [20].
• The marginal adaptation was rated as partly sealed (Oscar-Alpha) in 107 (92.2) of the restorations [21].
• Introduction. An Oscar for TGF-beta and its performance in the kidney [22].
• A theory of scandal: Victorians, homosexuality, and the fall of Oscar Wilde [23].

Analytical, diagnostic and therapeutic context of OSCAR

• Microchips versus stethoscopes, part 2: Revisiting OSCAR at the Foothills Hospital [24].
• We also interviewed 105 informed individuals of different ethnicities, all members of the multi-ethnic patients and carriers' organization 'OSCAR Nederland'. RESULTS: On average, 68% of the Surinamese Hindustanis and 42% of the Surinamese Afro-Americans were in favor of selective abortion in case of affected pregnancy [25].
• This surgical approach has been modified such that with the aid of an ultrasonically driven cement removal instrument (OSCAR) the length of the osteotomy is reduced, preserving bone stock, and it is possible to implant a shorter prosthesis in approximately 60% of cases [26].
• An objective scaling of facial nerve function based on area analysis (OSCAR) was developed using the variations of luminance produced by changes of facial expression [27].
• Subzero isoelectric focusing experiments suggest that rHb Oscar does not have dissociation properties like those of Hb A [17].

References