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Gene Review:

Nlrp5 - NLR family, pyrin domain containing 5

Mus musculus

Synonyms: Mater, Mater protein, Maternal antigen that embryos require, NACHT, LRR and PYD domains-containing protein 5, Nalp5, ...

Tong, Z.B. et al., Nelson, L.M., Pennetier, S. et al., Horikawa, M. et al., Tong, Z.B. et al., et al.

Nelson, Tong, Gold, De Pol, Vanevski, Dorward, Sena, Palumbo, Bondy, Nelson, Tong, Nelson, Dean, Pennetier, Perreau, Uzbekova, Thélie, Delaleu, Mermillod, Dalbiès-Tran,

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Disease relevance of Nlrp5

While investigating this animal model we cloned a novel gene that encodes an ooplasm-specific antigen associated with autoimmune oophoritis in mice [1].

High impact information on Nlrp5

We show here that Mater, a mouse oocyte protein dependent on the maternal genome, is essential for embryonic development beyond the two-cell stage [2].
Sequence analysis of Mater identified allelic, strain-specific splice variants between A/J and C57BL/6J mice making it an attractive candidate gene for Aod5 [3].
Here we show the expressional profile of Mater and its protein during oogenesis and embryogenesis as well as its subcellular localization in oocytes [4].
Taken together, our data indicate that Mater gene transcription and protein translation are active during oogenesis, but appear inactive during early embryogenesis [4].
By ribonuclease protection assay, Mater mRNA was abundant in germinal vesicle oocytes, but was undetectable in all stages of preimplantation embryos [4].

Biological context of Nlrp5

BACKGROUND: Mater (Maternal Antigen that Embryos Require), also known as Nalp5 (NACHT, leucine rich repeat and PYD containing 5), is an oocyte-specific maternal effect gene required for early embryonic development beyond the two-cell stage in mouse [5].
The longest open reading frame (3333 bp) encodes an oocyte-specific protein, designated OP1 (ooplasm-specific protein 1) [6].
MATER (Maternal Antigen That Embryos Require) is an ooplasm-specific protein first identified as an antigen (OP1) associated with ovarian autoimmunity in mice [7].

Associations of Nlrp5 with chemical compounds

Protein BLAST analysis of the NALP14 sequence revealed 2 previously reported germ cell-specific homologs (i.e., MATER [Maternal Antigen That Embryos Require], RNH2 [RiboNuclease/Angiogenin Inhibitor 2], and NALP4c) [8].

Other interactions of Nlrp5

Based on its role in preimplantation development, we have designated this antigen Maternal Antigen That Embryos Require (MATER) [1].

Analytical, diagnostic and therapeutic context of Nlrp5

In situ hybridization showed that Mater mRNA appeared progressively less abundant in oocytes beyond type 5a primary follicles [4].

References

Autoimmune ovarian failure: comparing the mouse model and the human disease. Nelson, L.M. J. Soc. Gynecol. Investig. (2001) [Pubmed]
Mater, a maternal effect gene required for early embryonic development in mice. Tong, Z.B., Gold, L., Pfeifer, K.E., Dorward, H., Lee, E., Bondy, C.A., Dean, J., Nelson, L.M. Nat. Genet. (2000) [Pubmed]
Interacting quantitative trait loci control loss of peripheral tolerance and susceptibility to autoimmune ovarian dysgenesis after day 3 thymectomy in mice. Roper, R.J., Ma, R.Z., Biggins, J.E., Butterfield, R.J., Michael, S.D., Tung, K.S., Doerge, R.W., Teuscher, C. J. Immunol. (2002) [Pubmed]
Developmental expression and subcellular localization of mouse MATER, an oocyte-specific protein essential for early development. Tong, Z.B., Gold, L., De Pol, A., Vanevski, K., Dorward, H., Sena, P., Palumbo, C., Bondy, C.A., Nelson, L.M. Endocrinology (2004) [Pubmed]
MATER protein expression and intracellular localization throughout folliculogenesis and preimplantation embryo development in the bovine. Pennetier, S., Perreau, C., Uzbekova, S., Thélie, A., Delaleu, B., Mermillod, P., Dalbiès-Tran, R. BMC Dev. Biol. (2006) [Pubmed]
A mouse gene encoding an oocyte antigen associated with autoimmune premature ovarian failure. Tong, Z.B., Nelson, L.M. Endocrinology (1999) [Pubmed]
Mater encodes a maternal protein in mice with a leucine-rich repeat domain homologous to porcine ribonuclease inhibitor. Tong, Z.B., Nelson, L.M., Dean, J. Mamm. Genome (2000) [Pubmed]
The mouse germ-cell-specific leucine-rich repeat protein NALP14: a member of the NACHT nucleoside triphosphatase family. Horikawa, M., Kirkman, N.J., Mayo, K.E., Mulders, S.M., Zhou, J., Bondy, C.A., Hsu, S.Y., King, G.J., Adashi, E.Y. Biol. Reprod. (2005) [Pubmed]

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