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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Oophoritis


High impact information on Oophoritis

  • A strong argument against an autoimmune pathogenesis of POF in these patients is the nearly absent histological confirmation (the presence of an oöphoritis) in these cases (< 3%) [2].
  • These T cells, which produced comparable amounts of interleukin 4 and interferon gamma in vitro, were able to transfer oophoritis to normal recipients [3].
  • Herein we show that blockage of glycoprotein (gp)39 and CD40 interaction with gp39 monoclonal antibody (mAb) results in the failure to induce both autoimmune oophoritis and autoantibody production [3].
  • Study on cellular events in post-thymectomy autoimmune oophoritis in mice. II. Requirement of Lyt-1 cells in normal female mice for the prevention of oophoritis [4].
  • The phenotypic spectrum of AOD is characterized by the development of anti-ovarian autoantibodies, oophoritis, and atrophy [5].

Chemical compound and disease context of Oophoritis

  • We describe the clinical course of three women with presumptive autoimmune oophoritis who developed multiple follicles but very low to undetectable estradiol levels [6].
  • In mice with oophoritis, circulating autoantibodies against, ooplasm, zona pellucida, or steroid-producing cells were constantly detected by immunohistochemical assay [7].
  • Levels of estradiol 17 beta (E2) and testosterone (T) did not vary in the Tx-3 mice compared to those of the intact mice through 21 months of age but progesterone levels were lower during the exacerbation of the autoimmune oophoritis and tumor development [8].
  • Oophoritis in a dog with abnormal corpus luteum function [9].

Anatomical context of Oophoritis


Gene context of Oophoritis

  • Congenic mapping studies revealed that Aod1 controls susceptibility to oophoritis and comprises two linked QTL with opposing allelic effects [13].
  • Manipulations that restored the postnatal shift to an adult Th1-dominant pattern ameliorated the autoimmune oophoritis [14].
  • Murine postthymectomy autoimmune oophoritis develops in association with a persistent neonatal-like Th2 response [14].
  • When mated, recovered mice were fertile and produced normal litters; and, as recipients of a ZP3-specific T cell line, their ovaries developed oophoritis [10].
  • Oophoritis resistance was not explicable by immunosuppressive effect of CFA priming, nor by suppression of pathogenic T cells [10].

Analytical, diagnostic and therapeutic context of Oophoritis


  1. Xanthogranulomatous oophoritis and salpingitis: late sequelae of inadequately treated staphylococcal PID. Punia, R.S., Aggarwal, R., Amanjit, n.u.l.l., Mohan, H. Indian journal of pathology & microbiology. (2003) [Pubmed]
  2. Premature ovarian failure and ovarian autoimmunity. Hoek, A., Schoemaker, J., Drexhage, H.A. Endocr. Rev. (1997) [Pubmed]
  3. The relative contribution of the CD28 and gp39 costimulatory pathways in the clonal expansion and pathogenic acquisition of self-reactive T cells. Griggs, N.D., Agersborg, S.S., Noelle, R.J., Ledbetter, J.A., Linsley, P.S., Tung, K.S. J. Exp. Med. (1996) [Pubmed]
  4. Study on cellular events in post-thymectomy autoimmune oophoritis in mice. II. Requirement of Lyt-1 cells in normal female mice for the prevention of oophoritis. Sakaguchi, S., Takahashi, T., Nishizuka, Y. J. Exp. Med. (1982) [Pubmed]
  5. Aod1, the immunoregulatory locus controlling abrogation of tolerance in neonatal thymectomy-induced autoimmune ovarian dysgenesis, maps to mouse chromosome 16. Wardell, B.B., Michael, S.D., Tung, K.S., Todd, J.A., Blankenhorn, E.P., McEntee, K., Sudweeks, J.D., Hansen, W.K., Meeker, N.D., Griffith, J.S. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  6. Selective theca cell dysfunction in autoimmune oophoritis results in multifollicular development, decreased estradiol, and elevated inhibin B levels. Welt, C.K., Falorni, A., Taylor, A.E., Martin, K.A., Hall, J.E. J. Clin. Endocrinol. Metab. (2005) [Pubmed]
  7. Acute oocyte loss in experimental autoimmune oophoritis as a possible model of premature ovarian failure. Miyake, T., Taguchi, O., Ikeda, H., Sato, Y., Takeuchi, S., Nishizuka, Y. Am. J. Obstet. Gynecol. (1988) [Pubmed]
  8. Plasma protein and hormone profiles associated with autoimmune oophoritis and ovarian tumorigenesis in neonatally thymectomized mice. Michael, S.D., De Angelo, L., Kaikis-Astaras, A. Autoimmunity (1990) [Pubmed]
  9. Oophoritis in a dog with abnormal corpus luteum function. Nickel, R.F., Okkens, A.C., van der Gaag, I., van Haaften, B. Vet. Rec. (1991) [Pubmed]
  10. Altered target organ. A mechanism of postrecovery resistance to murine autoimmune oophoritis. Lou, Y.H., McElveen, F., Adams, S., Tung, K.S. J. Immunol. (1995) [Pubmed]
  11. Effects of alpha-MSH on progesterone and nitric oxide release by cultured ovarian granulosa cells in experimental rat autoimmune oophoritis. Casalino-Matsuda, S.M., Durando, P.E., Celis, M.E. Journal of physiology and biochemistry. (2002) [Pubmed]
  12. Autoimmune oophoritis as a mechanism of follicular dysfunction in women with 46,XX spontaneous premature ovarian failure. Bakalov, V.K., Anasti, J.N., Calis, K.A., Vanderhoof, V.H., Premkumar, A., Chen, S., Furmaniak, J., Smith, B.R., Merino, M.J., Nelson, L.M. Fertil. Steril. (2005) [Pubmed]
  13. Aod1 controlling day 3 thymectomy-induced autoimmune ovarian dysgenesis in mice encompasses two linked quantitative trait loci with opposing allelic effects on disease susceptibility. Roper, R.J., McAllister, R.D., Biggins, J.E., Michael, S.D., Min, S.H., Tung, K.S., Call, S.B., Gao, J., Teuscher, C. J. Immunol. (2003) [Pubmed]
  14. Murine postthymectomy autoimmune oophoritis develops in association with a persistent neonatal-like Th2 response. Maity, R., Caspi, R.R., Nair, S., Rizzo, L.V., Nelson, L.M. Clin. Immunol. Immunopathol. (1997) [Pubmed]
  15. Autoimmune ovarian failure: comparing the mouse model and the human disease. Nelson, L.M. J. Soc. Gynecol. Investig. (2001) [Pubmed]
  16. Autoimmune oophoritis: a histopathologic study of involved ovaries with immunologic characterization of the mononuclear cell infiltrate. Sedmak, D.D., Hart, W.R., Tubbs, R.R. Int. J. Gynecol. Pathol. (1987) [Pubmed]
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