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Gene Review

Ppp1r1a  -  protein phosphatase 1, regulatory...

Mus musculus

Synonyms: 0610038N18Rik, I-1, IPP-1, Protein phosphatase 1 regulatory subunit 1A, Protein phosphatase inhibitor 1, ...
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Disease relevance of Ppp1r1a


Psychiatry related information on Ppp1r1a


High impact information on Ppp1r1a


Chemical compound and disease context of Ppp1r1a


Biological context of Ppp1r1a


Anatomical context of Ppp1r1a


Associations of Ppp1r1a with chemical compounds

  • In contrast, conditioned place preference to cocaine is reduced in mice lacking DARPP-32, I-1, or both phosphoproteins [6].
  • Contraction in response to acetylcholine as well as Ca(2+) sensitivity were similar between WT and I-1((-/-)) aorta [21].
  • 4. In the portal vein, I-1 protein ablation was associated with a significant (P < 0.05) rightward shift in the EC(50) of isoproterenol relaxation (EC(50) = 10.4 +/- 1.4 nM) compared to the WT value (EC(50) = 3.5 +/- 0.2 nM) [21].
  • 5. Despite the prevalence of I-1 and its activation by PKA in the aorta, I-1 does not appear to play a significant role in contractile or relaxant responses to any pharmacomechanical or electromechanical agonists used [21].
  • 3. Despite the significant presence of I-1 in WT aorta, phenylephrine and KCl concentration- isometric force relations in the presence or absence of the PKA pathway activator isoproterenol (isoprenaline) were unchanged compared to I-1((-/-)) aorta. cGMP-dependent protein kinase (PKG) relaxation pathways were also not different [21].

Physical interactions of Ppp1r1a


Enzymatic interactions of Ppp1r1a


Regulatory relationships of Ppp1r1a


Other interactions of Ppp1r1a


Analytical, diagnostic and therapeutic context of Ppp1r1a


  1. Inhibition of plasminogen activators or matrix metalloproteinases prevents cardiac rupture but impairs therapeutic angiogenesis and causes cardiac failure. Heymans, S., Luttun, A., Nuyens, D., Theilmeier, G., Creemers, E., Moons, L., Dyspersin, G.D., Cleutjens, J.P., Shipley, M., Angellilo, A., Levi, M., Nübe, O., Baker, A., Keshet, E., Lupu, F., Herbert, J.M., Smits, J.F., Shapiro, S.D., Baes, M., Borgers, M., Collen, D., Daemen, M.J., Carmeliet, P. Nat. Med. (1999) [Pubmed]
  2. Plasminogen activator inhibitor-1 gene-deficient mice. II. Effects on hemostasis, thrombosis, and thrombolysis. Carmeliet, P., Stassen, J.M., Schoonjans, L., Ream, B., van den Oord, J.J., De Mol, M., Mulligan, R.C., Collen, D. J. Clin. Invest. (1993) [Pubmed]
  3. Hepatic fibrosis, glomerulosclerosis, and a lipodystrophy-like syndrome in PEPCK-TGF-beta1 transgenic mice. Clouthier, D.E., Comerford, S.A., Hammer, R.E. J. Clin. Invest. (1997) [Pubmed]
  4. Oncogenes in Ras signalling pathway dictate host-cell permissiveness to herpes simplex virus 1. Farassati, F., Yang, A.D., Lee, P.W. Nat. Cell Biol. (2001) [Pubmed]
  5. A Novel Molecular Targeting Compound as K-samII/FGF-R2 Phosphorylation Inhibitor, Ki23057, for Scirrhous Gastric Cancer. Nakamura, K., Yashiro, M., Matsuoka, T., Tendo, M., Shimizu, T., Miwa, A., Hirakawa, K. Gastroenterology (2006) [Pubmed]
  6. Reduction of cocaine place preference in mice lacking the protein phosphatase 1 inhibitors DARPP 32 or Inhibitor 1. Zachariou, V., Benoit-Marand, M., Allen, P.B., Ingrassia, P., Fienberg, A.A., Gonon, F., Greengard, P., Picciotto, M.R. Biol. Psychiatry (2002) [Pubmed]
  7. Development of venous occlusions in mice transgenic for the plasminogen activator inhibitor-1 gene. Erickson, L.A., Fici, G.J., Lund, J.E., Boyle, T.P., Polites, H.G., Marotti, K.R. Nature (1990) [Pubmed]
  8. DARPP-32: regulator of the efficacy of dopaminergic neurotransmission. Fienberg, A.A., Hiroi, N., Mermelstein, P.G., Song, W., Snyder, G.L., Nishi, A., Cheramy, A., O'Callaghan, J.P., Miller, D.B., Cole, D.G., Corbett, R., Haile, C.N., Cooper, D.C., Onn, S.P., Grace, A.A., Ouimet, C.C., White, F.J., Hyman, S.E., Surmeier, D.J., Girault, J., Nestler, E.J., Greengard, P. Science (1998) [Pubmed]
  9. Plasminogen activator inhibitor-1 is a critical downstream target of p53 in the induction of replicative senescence. Kortlever, R.M., Higgins, P.J., Bernards, R. Nat. Cell Biol. (2006) [Pubmed]
  10. Selective inhibitors of the osteoblast proteasome stimulate bone formation in vivo and in vitro. Garrett, I.R., Chen, D., Gutierrez, G., Zhao, M., Escobedo, A., Rossini, G., Harris, S.E., Gallwitz, W., Kim, K.B., Hu, S., Crews, C.M., Mundy, G.R. J. Clin. Invest. (2003) [Pubmed]
  11. Metformin prevents alcohol-induced liver injury in the mouse: Critical role of plasminogen activator inhibitor-1. Bergheim, I., Guo, L., Davis, M.A., Lambert, J.C., Beier, J.I., Duveau, I., Luyendyk, J.P., Roth, R.A., Arteel, G.E. Gastroenterology (2006) [Pubmed]
  12. Vascular Endothelial Growth Factor Tyrosine Kinase Inhibitor AZD2171 and Fractionated Radiotherapy in Mouse Models of Lung Cancer. Cao, C., Albert, J.M., Geng, L., Ivy, P.S., Sandler, A., Johnson, D.H., Lu, B. Cancer Res. (2006) [Pubmed]
  13. Aging accelerates endotoxin-induced thrombosis : increased responses of plasminogen activator inhibitor-1 and lipopolysaccharide signaling with aging. Yamamoto, K., Shimokawa, T., Yi, H., Isobe, K., Kojima, T., Loskutoff, D.J., Saito, H. Am. J. Pathol. (2002) [Pubmed]
  14. Entrapment of Rho ADP-ribosylated by Clostridium botulinum C3 exoenzyme in the Rho-guanine nucleotide dissociation inhibitor-1 complex. Genth, H., Gerhard, R., Maeda, A., Amano, M., Kaibuchi, K., Aktories, K., Just, I. J. Biol. Chem. (2003) [Pubmed]
  15. Proteasome Inhibitor PS-341 Induces Apoptosis in Cisplatin-resistant Squamous Cell Carcinoma Cells by Induction of Noxa. Fribley, A.M., Evenchik, B., Zeng, Q., Park, B.K., Guan, J.Y., Zhang, H., Hale, T.J., Soengas, M.S., Kaufman, R.J., Wang, C.Y. J. Biol. Chem. (2006) [Pubmed]
  16. Receptor activator of NF-kappaB ligand, macrophage inflammatory protein-1alpha, and the proteasome: novel therapeutic targets in myeloma. Oyajobi, B.O., Mundy, G.R. Cancer (2003) [Pubmed]
  17. Dopamine D(1) receptor-induced gene transcription is modulated by DARPP-32. Svenningsson, P., Fienberg, A.A., Allen, P.B., Moine, C.L., Lindskog, M., Fisone, G., Greengard, P., Fredholm, B.B. J. Neurochem. (2000) [Pubmed]
  18. Expression and genomic characterization of protein phosphatase inhibitor-1: a novel marker for mesothelium in the mouse. McLaren, L., Boyle, S., Mason, J.O., Bard, J.B. Mech. Dev. (2000) [Pubmed]
  19. Gene expression profiling of mice with genetically modified muscle glycogen content. Parker, G.E., Pederson, B.A., Obayashi, M., Schroeder, J.M., Harris, R.A., Roach, P.J. Biochem. J. (2006) [Pubmed]
  20. Phosphorylation of protein phosphatase-1 inhibitors, inhibitor-1 and DARPP-32, in renal medulla. Higuchi, E., Nishi, A., Higashi, H., Ito, Y., Kato, H. Eur. J. Pharmacol. (2000) [Pubmed]
  21. Is myosin phosphatase regulated in vivo by inhibitor-1? Evidence from inhibitor-1 knockout mice. Carr, A.N., Sutliff, R.L., Weber, C.S., Allen, P.B., Greengard, P., de Lanerolle, P., Kranias, E.G., Paul, R.J. J. Physiol. (Lond.) (2001) [Pubmed]
  22. DARPP-32 and inhibitor-1 are expressed in pancreatic beta-cells. Lilja, L., Meister, B., Berggren, P.O., Bark, C. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
  23. Analysis of the binding of pro-urokinase and urokinase-plasminogen activator inhibitor-1 complex to the low density lipoprotein receptor-related protein using a Fab fragment selected from a phage-displayed Fab library. Horn, I.R., Moestrup, S.K., van den Berg, B.M., Pannekoek, H., Nielsen, M.S., van Zonneveld, A.J. J. Biol. Chem. (1995) [Pubmed]
  24. Phosphorylation of protein phosphatase inhibitor-1 by Cdk5. Bibb, J.A., Nishi, A., O'Callaghan, J.P., Ule, J., Lan, M., Snyder, G.L., Horiuchi, A., Saito, T., Hisanaga , S., Czernik, A.J., Nairn, A.C., Greengard, P. J. Biol. Chem. (2001) [Pubmed]
  25. Plasminogen activator inhibitor-1 expression and secretion are stimulated by growth hormone and interleukin-6 in 3T3-L1 adipocytes. Kralisch, S., Klein, J., Lossner, U., Blüher, M., Paschke, R., Stumvoll, M., Fasshauer, M. Mol. Cell. Endocrinol. (2006) [Pubmed]
  26. Insulin-like growth factor II inhibits glucose-induced insulin exocytosis. Zhang, Q., Berggren, P.O., Larsson, O., Hall, K., Tally, M. Biochem. Biophys. Res. Commun. (1998) [Pubmed]
  27. Lack of plasminogen activator inhibitor-1 promotes growth and abnormal matrix remodeling of advanced atherosclerotic plaques in apolipoprotein E-deficient mice. Luttun, A., Lupu, F., Storkebaum, E., Hoylaerts, M.F., Moons, L., Crawley, J., Bono, F., Poole, A.R., Tipping, P., Herbert, J.M., Collen, D., Carmeliet, P. Arterioscler. Thromb. Vasc. Biol. (2002) [Pubmed]
  28. Differential requirement for type I and type II transforming growth factor beta receptor kinase activity in ligand-mediated receptor endocytosis. Anders, R.A., Doré, J.J., Arline, S.L., Garamszegi, N., Leof, E.B. J. Biol. Chem. (1998) [Pubmed]
  29. Partial inhibition of PP1 alters bidirectional synaptic plasticity in the hippocampus. Jouvenceau, A., Hédou, G., Potier, B., Kollen, M., Dutar, P., Mansuy, I.M. Eur. J. Neurosci. (2006) [Pubmed]
  30. Tumor necrosis factor alpha is a key component in the obesity-linked elevation of plasminogen activator inhibitor 1. Samad, F., Uysal, K.T., Wiesbrock, S.M., Pandey, M., Hotamisligil, G.S., Loskutoff, D.J. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  31. Signals transducers and activators of transcription (STAT)-induced STAT inhibitor-1 (SSI-1)/suppressor of cytokine signaling-1 (SOCS-1) suppresses tumor necrosis factor alpha-induced cell death in fibroblasts. Morita, Y., Naka, T., Kawazoe, Y., Fujimoto, M., Narazaki, M., Nakagawa, R., Fukuyama, H., Nagata, S., Kishimoto, T. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  32. Targeted disruption of Smad3 reveals an essential role in transforming growth factor beta-mediated signal transduction. Datto, M.B., Frederick, J.P., Pan, L., Borton, A.J., Zhuang, Y., Wang, X.F. Mol. Cell. Biol. (1999) [Pubmed]
  33. Signal transducer and activator of transcription (STAT)-induced STAT inhibitor 1 (SSI-1)/suppressor of cytokine signaling 1 (SOCS1) inhibits insulin signal transduction pathway through modulating insulin receptor substrate 1 (IRS-1) phosphorylation. Kawazoe, Y., Naka, T., Fujimoto, M., Kohzaki, H., Morita, Y., Narazaki, M., Okumura, K., Saitoh, H., Nakagawa, R., Uchiyama, Y., Akira, S., Kishimoto, T. J. Exp. Med. (2001) [Pubmed]
  34. Inhibitory role of plasminogen activator inhibitor-1 in arterial wound healing and neointima formation: a gene targeting and gene transfer study in mice. Carmeliet, P., Moons, L., Lijnen, R., Janssens, S., Lupu, F., Collen, D., Gerard, R.D. Circulation (1997) [Pubmed]
  35. Measurement of plasminogen activator inhibitor 1 in biologic fluids with a murine monoclonal antibody-based enzyme-linked immunosorbent assay. Declerck, P.J., Alessi, M.C., Verstreken, M., Kruithof, E.K., Juhan-Vague, I., Collen, D. Blood (1988) [Pubmed]
  36. Localization in mammalian brain of G-substrate, a specific substrate for guanosine 3',5'-cyclic monophosphate-dependent protein kinase. Detre, J.A., Nairn, A.C., Aswad, D.W., Greengard, P. J. Neurosci. (1984) [Pubmed]
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