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Gene Review:

Spry4 - sprouty homolog 4 (Drosophila)

Mus musculus

Synonyms: A030006O18Rik, Protein sprouty homolog 4, Spry-4, sprouty4

Perl, A.K. et al., Leeksma, O.C. et al., Klein, O.D. et al., Lee, S.H. et al.

Leeksma, Van Achterberg, Tsumura, Toshima, Eldering, Kroes, Mellink, Spaargaren, Mizuno, Pannekoek, de Vries,

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Disease relevance of Spry4

We show that different Sprouty genes are deployed in different tissue compartments--Spry2 in epithelium and Spry4 in mesenchyme--to prevent diastema tooth formation [1].
Expression of Spry-4 during the saccular and alveolar stages, from E18.5 to postnatal day 21, caused mild emphysema [2].
Expression of Spry-4 from E16.5 to E18.5 reduced lung growth and resulted in perinatal death due to respiratory failure [2].

High impact information on Spry4

Sprouty-4 expression inhibited branching and sprouting of small vessels, resulting in abnormal embryonic development [3].
To determine the temporal requirements for FGF signaling during pulmonary morphogenesis, Sprouty-4 (Spry-4), an intracellular FGF receptor antagonist, was expressed in epithelial cells of the fetal lung under control of a doxycycline-inducible system [2].
5. Effects of Spry-4 on branching were substantially reversed by removal of doxycycline from the dam at E12.5, but not at E13 [2].
By differential display RT-PCR of activated vs. resting umbilical artery smooth muscle cells (SMCs) we detected a new human sprouty gene, which we designated human sprouty 4 (hspry4) based on its homology with murine sprouty 4 [4].

References

Sprouty genes control diastema tooth development via bidirectional antagonism of epithelial-mesenchymal FGF signaling. Klein, O.D., Minowada, G., Peterkova, R., Kangas, A., Yu, B.D., Lesot, H., Peterka, M., Jernvall, J., Martin, G.R. Dev. Cell (2006) [Pubmed]
Temporal effects of Sprouty on lung morphogenesis. Perl, A.K., Hokuto, I., Impagnatiello, M.A., Christofori, G., Whitsett, J.A. Dev. Biol. (2003) [Pubmed]
Inhibition of angiogenesis by a mouse sprouty protein. Lee, S.H., Schloss, D.J., Jarvis, L., Krasnow, M.A., Swain, J.L. J. Biol. Chem. (2001) [Pubmed]
Human sprouty 4, a new ras antagonist on 5q31, interacts with the dual specificity kinase TESK1. Leeksma, O.C., Van Achterberg, T.A., Tsumura, Y., Toshima, J., Eldering, E., Kroes, W.G., Mellink, C., Spaargaren, M., Mizuno, K., Pannekoek, H., de Vries, C.J. Eur. J. Biochem. (2002) [Pubmed]

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SPRY4	Bos taurus
SPRY4	Canis lupus familiaris
spry4	Danio rerio
SPRY4	Gallus gallus
LOC100858637	Gallus gallus
SPRY4	Homo sapiens
SPRY4	Macaca mulatta
SPRY4	Pan troglodytes
Spry4	Rattus norvegicus
spry4	Xenopus (Silurana) tropicalis

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