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Gene Review

SPRY4  -  sprouty homolog 4 (Drosophila)

Homo sapiens

Synonyms: Protein sprouty homolog 4, Spry-4
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Disease relevance of SPRY4


High impact information on SPRY4

  • This PXXPXR motif binds directly to the N-terminal Src homology domain 3 of Grb2, and when added onto the C terminus of Spry4 the resultant chimera inhibits the Ras/ERK pathway [2].
  • Homology analysis further showed that the core promoter region of the hSpry4 gene exhibits significant similarity to the 5'-flanking region of the mouse gene [3].
  • Transient transfection using luciferase reporter gene constructs with progressive deletions of the hSpry4 5'-flanking region revealed that the core promoter activity is located within the proximal 0.4-kb region, whereas the minimal ERK-inducible promoter activity is between -69 and -31 [3].
  • The hSpry4 gene spans > 14 kb and is organized in three exons and two introns [3].
  • FGF18, FGF20 and SPRY4 are potent targets of the canonical WNT signaling pathway in the gastrointestinal tract [4].

Biological context of SPRY4


Anatomical context of SPRY4


Associations of SPRY4 with chemical compounds


Other interactions of SPRY4

  • We previously showed that TESK1 interacts with Sprouty-4 (referred to as Spry4), an inhibitor of growth factor-induced Ras/MAP (mitogen-activated protein) kinase signalling, but the functional role of this interaction has remained unknown [5].

Analytical, diagnostic and therapeutic context of SPRY4


  1. FGF signaling inhibitor, SPRY4, is evolutionarily conserved target of WNT signaling pathway in progenitor cells. Katoh, Y., Katoh, M. Int. J. Mol. Med. (2006) [Pubmed]
  2. A Src Homology 3-binding Sequence on the C Terminus of Sprouty2 Is Necessary for Inhibition of the Ras/ERK Pathway Downstream of Fibroblast Growth Factor Receptor Stimulation. Lao, D.H., Chandramouli, S., Yusoff, P., Fong, C.W., Saw, T.Y., Tai, L.P., Yu, C.Y., Leong, H.F., Guy, G.R. J. Biol. Chem. (2006) [Pubmed]
  3. Genomic structure and promoter characterization of the human Sprouty4 gene, a novel regulator of lung morphogenesis. Ding, W., Bellusci, S., Shi, W., Warburton, D. Am. J. Physiol. Lung Cell Mol. Physiol. (2004) [Pubmed]
  4. FGF signaling network in the gastrointestinal tract (review). Katoh, M., Katoh, M. Int. J. Oncol. (2006) [Pubmed]
  5. Sprouty-4 negatively regulates cell spreading by inhibiting the kinase activity of testicular protein kinase. Tsumura, Y., Toshima, J., Leeksma, O.C., Ohashi, K., Mizuno, K. Biochem. J. (2005) [Pubmed]
  6. Assignment of human sprouty 4 gene to chromosome segment 5q32 approximately 33 and analysis of its pattern of expression. Liu, H., Chen, J.Z., Gu, S.H., Dai, J.L., Zhao, E.P., Huang, L., Xu, W.X., Xie, Y., Mao, Y.M. J. Genet. (2003) [Pubmed]
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