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Gene Review

Add1  -  adducin 1 (alpha)

Rattus norvegicus

Synonyms: Alpha-adducin, Erythrocyte adducin subunit alpha
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Disease relevance of Add1


High impact information on Add1


Chemical compound and disease context of Add1

  • In this short editorial review, we summarize the recent experimental, clinical and epidemiological evidence that contributed to our understanding of the pathogenetic mechanisms that lead to hypertension associated with the alpha-adducin Gly460Trp polymorphism and its interaction with ouabain [6].
  • In rats and humans, mutation of the alpha-adducin subunit leads to the stimulation of the sodium (Na(+)), potassium (K(+))-adenosine triphosphate (ATP)-ase activity in renal tubular cells, increased renal Na(+) reabsorption, and, subsequently, hypertension [6].

Biological context of Add1


Anatomical context of Add1


Associations of Add1 with chemical compounds

  • Plasma ouabain levels increase with the number of copies of the mutated alpha-adducin allele [6].

Other interactions of Add1

  • In the present study, a genomewide search with 264 informative markers was undertaken in 251 (Milan hypertensive strain x Milan normotensive strain) F2 rats to further investigate the contribution of the adducin gene family (Add1, Add2, and Add3) and to identify novel quantitative trait loci (QTLs) that affect blood pressure [7].


  1. Association between the alpha-adducin Gly460Trp polymorphism and systolic blood pressure in familial combined hyperlipidemia. Beeks, E., Janssen, R.G., Kroon, A.A., Keulen, E.T., Geurts, J.M., de Leeuw, P.W., de Bruin, T.W. Am. J. Hypertens. (2001) [Pubmed]
  2. 35H, a sequence isolated as a protein kinase C binding protein, is a novel member of the adducin family. Dong, L., Chapline, C., Mousseau, B., Fowler, L., Ramsay, K., Stevens, J.L., Jaken, S. J. Biol. Chem. (1995) [Pubmed]
  3. Transformation-sensitive changes in expression, localization, and phosphorylation of adducins in renal proximal tubule epithelial cells. Fowler, L., Dong, L., Bowes, R.C., van de Water, B., Stevens, J.L., Jaken, S. Cell Growth Differ. (1998) [Pubmed]
  4. Effect of Add1 gene transfer on blood pressure in reciprocal congenic strains of Milan rats. Tripodi, G., Florio, M., Ferrandi, M., Modica, R., Zimdahl, H., Hubner, N., Ferrari, P., Bianchi, G. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
  5. Spatial and sub-cellular localization of the membrane cytoskeleton-associated protein alpha-adducin in the rat brain. Seidel, B., Zuschratter, W., Wex, H., Garner, C.C., Gundelfinger, E.D. Brain Res. (1995) [Pubmed]
  6. Adducin and hypertension. Staessen, J.A., Bianchi, G. Pharmacogenomics (2005) [Pubmed]
  7. Genetic mapping of blood pressure quantitative trait loci in Milan hypertensive rats. Zagato, L., Modica, R., Florio, M., Torielli, L., Bihoreau, M.T., Bianchi, G., Tripodi, G. Hypertension (2000) [Pubmed]
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