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Gene Review

Nsf  -  N-ethylmaleimide sensitive fusion protein

Mus musculus

Synonyms: AI316878, AU020090, AU067812, N-ethylmaleimide sensitive factor, N-ethylmaleimide-sensitive fusion protein, ...
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Disease relevance of Nsf


High impact information on Nsf

  • Nitric oxide regulates exocytosis by S-nitrosylation of N-ethylmaleimide-sensitive factor [1].
  • NO inhibits NSF disassembly of soluble NSF attachment protein receptor (SNARE) complexes by nitrosylating critical cysteine residues of NSF [1].
  • S-nitrosylation of NSF augments its binding to the AMPAR GluR2 subunit [5].
  • Thus, AMPAR recycling elicited by NMDA neurotransmission is mediated by a cascade involving NMDA activation of neuronal NO synthase to form NO, leading to S-nitrosylation of NSF which is thereby activated, enabling it to bind to GluR2 and promote the receptor's surface expression [5].
  • H(2)O(2) decreases the ability of NSF to hydrolyze adenosine triphosphate and to disassemble the soluble NSF attachment protein receptor complex [6].

Biological context of Nsf


Anatomical context of Nsf


Associations of Nsf with chemical compounds


Physical interactions of Nsf


Regulatory relationships of Nsf


Other interactions of Nsf


Analytical, diagnostic and therapeutic context of Nsf


  1. Nitric oxide regulates exocytosis by S-nitrosylation of N-ethylmaleimide-sensitive factor. Matsushita, K., Morrell, C.N., Cambien, B., Yang, S.X., Yamakuchi, M., Bao, C., Hara, M.R., Quick, R.A., Cao, W., O'Rourke, B., Lowenstein, J.M., Pevsner, J., Wagner, D.D., Lowenstein, C.J. Cell (2003) [Pubmed]
  2. The gene for soluble N-ethylmaleimide sensitive factor attachment protein alpha is mutated in hydrocephaly with hop gait (hyh) mice. Hong, H.K., Chakravarti, A., Takahashi, J.S. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  3. Live Salmonella recruits N-ethylmaleimide-sensitive fusion protein on phagosomal membrane and promotes fusion with early endosome. Mukherjee, K., Siddiqi, S.A., Hashim, S., Raje, M., Basu, S.K., Mukhopadhyay, A. J. Cell Biol. (2000) [Pubmed]
  4. A novel inhibitor of N-ethylmaleimide-sensitive factor decreases leukocyte trafficking and peritonitis. Morrell, C.N., Matsushita, K., Lowenstein, C.J. J. Pharmacol. Exp. Ther. (2005) [Pubmed]
  5. S-nitrosylation of N-ethylmaleimide sensitive factor mediates surface expression of AMPA receptors. Huang, Y., Man, H.Y., Sekine-Aizawa, Y., Han, Y., Juluri, K., Luo, H., Cheah, J., Lowenstein, C., Huganir, R.L., Snyder, S.H. Neuron (2005) [Pubmed]
  6. Hydrogen peroxide regulation of endothelial exocytosis by inhibition of N-ethylmaleimide sensitive factor. Matsushita, K., Morrell, C.N., Mason, R.J., Yamakuchi, M., Khanday, F.A., Irani, K., Lowenstein, C.J. J. Cell Biol. (2005) [Pubmed]
  7. Direct interaction of N-ethylmaleimide-sensitive factor with GABA(A) receptor beta subunits. Goto, H., Terunuma, M., Kanematsu, T., Misumi, Y., Moss, S.J., Hirata, M. Mol. Cell. Neurosci. (2005) [Pubmed]
  8. SNAP-25 Ser187 does not mediate phorbol ester enhancement of hippocampal synaptic transmission. Finley, M.F., Scheller, R.H., Madison, D.V. Neuropharmacology (2003) [Pubmed]
  9. Developmentally regulated switch in alternatively spliced SNAP-25 isoforms alters facilitation of synaptic transmission. Bark, C., Bellinger, F.P., Kaushal, A., Mathews, J.R., Partridge, L.D., Wilson, M.C. J. Neurosci. (2004) [Pubmed]
  10. Functional repair of motor endplates after botulinum neurotoxin type A poisoning: biphasic switch of synaptic activity between nerve sprouts and their parent terminals. de Paiva, A., Meunier, F.A., Molgó, J., Aoki, K.R., Dolly, J.O. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  11. A mechanism underlying AMPA receptor trafficking during cerebellar long-term potentiation. Kakegawa, W., Yuzaki, M. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  12. Role of SNAP23 in insulin-induced translocation of GLUT4 in 3T3-L1 adipocytes. Mediation of complex formation between syntaxin4 and VAMP2. Kawanishi, M., Tamori, Y., Okazawa, H., Araki, S., Shinoda, H., Kasuga, M. J. Biol. Chem. (2000) [Pubmed]
  13. Analysis of SNAP-25 immunoreactivity in hippocampal inhibitory neurons during development in culture and in situ. Frassoni, C., Inverardi, F., Coco, S., Ortino, B., Grumelli, C., Pozzi, D., Verderio, C., Matteoli, M. Neuroscience (2005) [Pubmed]
  14. Distribution of synaptosomal-associated protein 25 in nerve growth cones and reduction of neurite outgrowth by botulinum neurotoxin A without altering growth cone morphology in dorsal root ganglion neurons and PC-12 cells. Morihara, T., Mizoguchi, A., Takahashi, M., Kozaki, S., Tsujihara, T., Kawano, S., Shirasu, M., Ohmukai, T., Kitada, M., Kimura, K., Okajima, S., Tamai, K., Hirasawa, Y., Ide, C. Neuroscience (1999) [Pubmed]
  15. The PDZ-binding motif of the beta2-adrenoceptor is essential for physiologic signaling and trafficking in cardiac myocytes. Xiang, Y., Kobilka, B. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  16. A 29-kilodalton Golgi soluble N-ethylmaleimide-sensitive factor attachment protein receptor (Vti1-rp2) implicated in protein trafficking in the secretory pathway. Xu, Y., Wong, S.H., Tang, B.L., Subramaniam, V.N., Zhang, T., Hong, W. J. Biol. Chem. (1998) [Pubmed]
  17. Characterization of Rab5:Q79L-stimulated endosome fusion. Barbieri, M.A., Li, G., Mayorga, L.S., Stahl, P.D. Arch. Biochem. Biophys. (1996) [Pubmed]
  18. Cycling of NMDA receptors during trafficking in neurons before synapse formation. Washbourne, P., Liu, X.B., Jones, E.G., McAllister, A.K. J. Neurosci. (2004) [Pubmed]
  19. HMG-CoA reductase inhibitors inhibit endothelial exocytosis and decrease myocardial infarct size. Yamakuchi, M., Greer, J.J., Cameron, S.J., Matsushita, K., Morrell, C.N., Talbot-Fox, K., Baldwin, W.M., Lefer, D.J., Lowenstein, C.J. Circ. Res. (2005) [Pubmed]
  20. Cross talk between tetanus neurotoxin-insensitive vesicle-associated membrane protein-mediated transport and L1-mediated adhesion. Alberts, P., Rudge, R., Hinners, I., Muzerelle, A., Martinez-Arca, S., Irinopoulou, T., Marthiens, V., Tooze, S., Rathjen, F., Gaspar, P., Galli, T. Mol. Biol. Cell (2003) [Pubmed]
  21. Two distinct genes drive expression of seven tomosyn isoforms in the mammalian brain, sharing a conserved structure with a unique variable domain. Groffen, A.J., Jacobsen, L., Schut, D., Verhage, M. J. Neurochem. (2005) [Pubmed]
  22. Expression and function of SNAP-25 as a universal SNARE component in GABAergic neurons. Tafoya, L.C., Mameli, M., Miyashita, T., Guzowski, J.F., Valenzuela, C.F., Wilson, M.C. J. Neurosci. (2006) [Pubmed]
  23. N-ethylmaleimide-sensitive factor is required for the synaptic incorporation and removal of AMPA receptors during cerebellar long-term depression. Steinberg, J.P., Huganir, R.L., Linden, D.J. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  24. Structural determinants of synaptobrevin 2 function in synaptic vesicle fusion. Deák, F., Shin, O.H., Kavalali, E.T., Südhof, T.C. J. Neurosci. (2006) [Pubmed]
  25. Syntaxin 6 regulates Glut4 trafficking in 3T3-L1 adipocytes. Perera, H.K., Clarke, M., Morris, N.J., Hong, W., Chamberlain, L.H., Gould, G.W. Mol. Biol. Cell (2003) [Pubmed]
  26. The DEP domain determines subcellular targeting of the GTPase activating protein RGS9 in vivo. Martemyanov, K.A., Lishko, P.V., Calero, N., Keresztes, G., Sokolov, M., Strissel, K.J., Leskov, I.B., Hopp, J.A., Kolesnikov, A.V., Chen, C.K., Lem, J., Heller, S., Burns, M.E., Arshavsky, V.Y. J. Neurosci. (2003) [Pubmed]
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