Disease relevance of S100a4

• The decrease in enzymic activity ranged from 16 to 19% for the slow-growing tumors (Hepatomas 44, 28A, and 9633), 2 to 9% for the intermediate-growing tumors (Hepatomas 38B, 7795, and 5123A), and 0% for the fast-growing tumors (Hepatomas 7288C, 7777, and 42A) [1].
• The expression of pEL98 (mts1) was also found to be correlated with motile and invasive abilities in various clones derived from Lewis lung carcinoma [2].

High impact information on S100a4

• The conservation of primary and secondary structure between 42A, 42C, and the other proteins suggests a possible role for them in the regulation of cell growth and differentiation [3].
• Placental calcium binding protein in rats. Apparent identity with vitamin D-dependent calcium binding protein from rat intestine [4].
• Immunoselection of recombinant clones from a KNRK-specific lambda gt11 cDNA library allowed identification of the 59K and 10K proteins as transin 2 and an S-100-related calcium-binding protein identified as p9Ka/42A but not previously associated with oncogenic transformation of rat cells [5].
• Metastasis-associated S100A4 (Mts1) protein is expressed in subpopulations of sensory and autonomic neurons and in Schwann cells of the adult rat [6].
• S100A4 (Mts1) is a member of a family of calcium-binding proteins of the EF-hand type, which are widely expressed in the nervous system, where they appear to be involved in the regulation of neuron survival, plasticity, and response to injury or disease [6].

Biological context of S100a4

• The induction of 42A and 42C mRNAs and repression of S100 beta mRNA remained if nerve regeneration was prevented.(ABSTRACT TRUNCATED AT 250 WORDS)[7]
• The expression level of pEL98 (mts1) correlated well with cell motility, which was examined by measuring cell tracks by phagokinesis [2].

Anatomical context of S100a4

• The levels of 42C and 42A mRNAs in sciatic nerve increased 4- and 14-fold, respectively, by postnatal day 23 compared to postnatal day 2 [7].
• Calvasculin encodes mRNA termed pEL-98, 18A2, 42A, p9Ka, or mts1, found to be elevated in several metastatic cell lines [8].
• In this procedure, we take advantage of our previous finding that white, but not gray matter astrocytes express the calcium-binding protein S100A4 [9].

Associations of S100a4 with chemical compounds

• The MTT 5 min metabolic inclusion test and MTS 1 h quantitative assay results correlated closely with those obtained by the 3HTdR, trypan blue dye exclusion, and fluorescein diacetate (FDA) methods [10].

References