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Gene Review

Mmp10  -  matrix metallopeptidase 10 (stromelysin 2)

Rattus norvegicus

Synonyms: MMP-10, Matrix metalloproteinase-10, SL-2, Stromelysin-2, Transformation-associated protein 34A, ...
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High impact information on Mmp10

  • The transformed rat embryo cell lines with high metastatic potential were found to produce high levels of the stromelysin 1 (MMP-3) and stromelysin 2 (MMP-10) proteases, while the nonmetastatic lines produced low or undetectable levels of these two enzymes [1].
  • The nucleotide sequence of 34A cDNA was determined, and a search of GenBank revealed that it is identical to that of rat transin-2 [2].
  • Immunoselection of recombinant clones from a KNRK-specific lambda gt11 cDNA library allowed identification of the 59K and 10K proteins as transin 2 and an S-100-related calcium-binding protein identified as p9Ka/42A but not previously associated with oncogenic transformation of rat cells [3].
  • Transin 2 detection by a cell-derived antiserum may also suggest the presence of specific cell-surface binding sites for this enzyme [3].
  • Nevertheless, transin-2 RNA is expressed in several transformed rat embryo fibroblast cell lines, and can be induced by a tumour promoter [4].

Anatomical context of Mmp10

  • Suggestive evidence was obtained that the late arising neurons of the medial thalamus (the anterior nuclei, the mediodorsal nucleus, and some or all of the midline nuclei) originate in a portion of the superior neuroepithelial lobule designated as SL2 [5].

Associations of Mmp10 with chemical compounds

  • The good in vitro and in vivo stability and high yields of the Tc-99m complexes of SL1 and SL2 indicate the potential hydrazido-thiols hold for use as a basis in formulating new Tc-99m radiopharmaceuticals, particularly when thiol moieties are used in conjunction with multi-functional phosphorous hydrazide compounds [6].
  • Rechromatography of an eluate from this spot with another solvent system resolved it into three spots (SL1, SL2 and SL3, the mixture being designated as Substance L) which could be visualized either with iodine vapour, ninhydrin or molybdenum reagent [7].

Other interactions of Mmp10

  • Indeed, a stretch of 428 nucleotides of the transin gene containing both exon and intron sequences is 98% conserved in the transin-2 gene [4].
  • Administration of the MMP-10 or the MMP-16 peptide prior to AA induction reduced the arthritic symptoms [8].

Analytical, diagnostic and therapeutic context of Mmp10

  • Neutral-lipophilic Tc-99m chelates with both SL1 and SL2 were formed in high yields (95-97%) as a single species ascertained by electrophoresis and reversed-phase HPLC [6].


  1. Expression of matrix metalloproteinase genes in transformed rat cell lines of high and low metastatic potential. Sreenath, T., Matrisian, L.M., Stetler-Stevenson, W., Gattoni-Celli, S., Pozzatti, R.O. Cancer Res. (1992) [Pubmed]
  2. Molecular cloning and characterization of v-mos-activated transformation-associated proteins. Chan, J.C., Scanlon, M., Zhang, H.Z., Jia, L.B., Yu, D.H., Hung, M.C., French, M., Eastman, E.M. J. Biol. Chem. (1992) [Pubmed]
  3. Transformation of normal rat kidney cells by v-K-ras enhances expression of transin 2 and an S-100-related calcium-binding protein. De Vouge, M.W., Mukherjee, B.B. Oncogene (1992) [Pubmed]
  4. Sequences coding for part of oncogene-induced transin are highly conserved in a related rat gene. Breathnach, R., Matrisian, L.M., Gesnel, M.C., Staub, A., Leroy, P. Nucleic Acids Res. (1987) [Pubmed]
  5. Development of the diencephalon in the rat. VI. Re-evaluation of the embryonic development of the thalamus on the basis of thymidine-radiographic datings. Altman, J., Bayer, S.A. J. Comp. Neurol. (1979) [Pubmed]
  6. Transition metal chemistry of main group hydrazides, Part 14: Evaluation of new Tc-99m chelates of thiol functionalized phosphorus hydrazides. Singh, P.R., Lusiak, P., Volkert, W.A., Ketring, A.R., Holmes, R.A., Katti, K.V. Nucl. Med. Biol. (1995) [Pubmed]
  7. Separation and partial characterization of smooth muscle contractile material in the venom of the scorpion Heterometrus bengalensis. Kar, P.K., Sarangi, B., Datta, A., Gomes, A., Lahiri, S.C. Toxicon (1983) [Pubmed]
  8. Successful immunotherapy with matrix metalloproteinase-derived peptides in adjuvant arthritis depends on the timing of peptide administration. van Bilsen, J.H., Wagenaar-Hilbers, J.P., van der Cammen, M.J., van Dijk, M.E., van Eden, W., Wauben, M.H. Arthritis Res. (2002) [Pubmed]
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