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Gene Review

Atxn1  -  ataxin 1

Rattus norvegicus

Synonyms: Ataxin-1, Sca1, Spinocerebellar ataxia type 1 protein homolog
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High impact information on Atxn1


Biological context of Atxn1

  • Oxidative damage of mutant ataxin-1 protein increased its recruitment in nuclear aggregates and increased cell death [3].

Analytical, diagnostic and therapeutic context of Atxn1

  • Sorted BM cells showed positive for Sca-1 (Ataxin-1) by immunofluorescence staining [6].
  • By using direct immunocytochemistry of BrU incorporated to RNA in the nuclei, we evaluated the effect of mutant huntingtin and ataxin-1 on general transcription in primary cortical and cerebellar neurons [7].


  1. Sca-1 expression identifies stem cells in the proximal region of prostatic ducts with high capacity to reconstitute prostatic tissue. Burger, P.E., Xiong, X., Coetzee, S., Salm, S.N., Moscatelli, D., Goto, K., Wilson, E.L. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  2. Transgene-activated mesenchymal cells for articular cartilage repair: a comparison of primary bone marrow-, perichondrium/periosteum- and fat-derived cells. Park, J., Gelse, K., Frank, S., von der Mark, K., Aigner, T., Schneider, H. The journal of gene medicine. (2006) [Pubmed]
  3. Oxidative stimuli affect polyglutamine aggregation and cell death in human mutant ataxin-1-expressing cells. Kim, S.J., Kim, T.S., Hong, S., Rhim, H., Kim, I.Y., Kang, S. Neurosci. Lett. (2003) [Pubmed]
  4. Ethanol induces cell-cycle activity and reduces stem cell diversity to alter both regenerative capacity and differentiation potential of cerebral cortical neuroepithelial precursors. Santillano, D.R., Kumar, L.S., Prock, T.L., Camarillo, C., Tingling, J.D., Miranda, R.C. BMC neuroscience [electronic resource]. (2005) [Pubmed]
  5. Prominent expression of spinocerebellar ataxia type-1 (SCA1) gene encoding ataxin-1 in LH-producing cells, LbetaT2. Ogawa, S., Aikawa, S., Kato, T., Tomizawa, K., Tsukamura, H., Maeda, K., Petric, N., Elsaesser, F., Kato, Y. J. Reprod. Dev. (2004) [Pubmed]
  6. Differentiation of bone marrow cells into cells that express liver-specific genes in vitro: implication of the Notch signals in differentiation. Okumoto, K., Saito, T., Hattori, E., Ito, J.I., Adachi, T., Takeda, T., Sugahara, K., Watanabe, H., Saito, K., Togashi, H., Kawata, S. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
  7. General transcriptional repression by polyglutamine disease proteins is not directly linked to the presence of inclusion bodies. Hoshino, M., Tagawa, K., Okuda, T., Okazawa, H. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
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