The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

suc1  -  cyclin-dependent protein kinase regulatory...

Schizosaccharomyces pombe 972h-

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of suc1


High impact information on suc1

  • Therefore, the cdc25+, cdc13+, and suc1+ gene products are important for regulating p34cdc2 protein kinase activity during entry into, progress through, and exit from mitosis [2].
  • The product of the fission yeast suc1 gene (p13), which inhibits the entry into mitosis in Xenopus extracts, completely blocks tyrosine dephosphorylation and kinase activation [3].
  • cdc2+ encodes a protein kinase that is required during both G1 and G2 phases of the cell division cycle in fission yeast. suc1+ is an essential gene that was originally identified as a plasmid-borne sequence that could rescue certain temperature-sensitive cdc2 mutants [1].
  • In our study, we have characterized the biochemical effect of loss of suc1 function on specific cdc2-cyclin complexes [4].
  • We also show that a dramatic increase in the level of the cdc13 protein is associated with loss of suc1 [4].

Biological context of suc1

  • The suppressing activity of suc1 is observed when it is present on a multicopy number plasmid [5].
  • One such suppressor, CKS1, was found to encode an 18-kilodalton protein that shared a high degree of homology with the suc1+ protein (p13) of Schizosaccharomyces pombe (67% amino acid sequence identity) [6].
  • An in vivo deletion of the complete brd1 open reading frame is not lethal but cells exhibit thermosensitivity, with reductions in both cell growth and stationary phase survival at 36 degrees C. brd1 maps adjacent to the gene suc1, but is expressed separately to give a low abundance 2.1 kb mRNA [7].

Anatomical context of suc1

  • BACKGROUND: The 113-residue alpha+beta protein suc1 is a member of the cyclin-dependent kinase subunit (cks) family of proteins that are involved in regulation of the eukaryotic cell cycle [8].

Associations of suc1 with chemical compounds

  • We have investigated the role of proline residues in suc1, a member of the cyclin-dependent kinase (cks) family of proteins, whose known function is to bind to and regulate the activity of the major mitotic cdk [9].

Regulatory relationships of suc1


Other interactions of suc1

  • We provide evidence that loss of suc1 function affects the kinase activity of the two distinct mitotic forms of the cdc2 kinase [4].
  • The biochemical functions of the cdc10 and suc1 gene products have not yet been elucidated [10].
  • We used suc1 as the target gene for disruption and ura4 as the selectable marker [11].

Analytical, diagnostic and therapeutic context of suc1


  1. p13suc1 acts in the fission yeast cell division cycle as a component of the p34cdc2 protein kinase. Brizuela, L., Draetta, G., Beach, D. EMBO J. (1987) [Pubmed]
  2. Regulation of p34cdc2 protein kinase during mitosis. Moreno, S., Hayles, J., Nurse, P. Cell (1989) [Pubmed]
  3. Fission yeast p13 blocks mitotic activation and tyrosine dephosphorylation of the Xenopus cdc2 protein kinase. Dunphy, W.G., Newport, J.W. Cell (1989) [Pubmed]
  4. p13suc1 of Schizosaccharomyces pombe regulates two distinct forms of the mitotic cdc2 kinase. Basi, G., Draetta, G. Mol. Cell. Biol. (1995) [Pubmed]
  5. The fission yeast cell cycle control gene cdc2: isolation of a sequence suc1 that suppresses cdc2 mutant function. Hayles, J., Beach, D., Durkacz, B., Nurse, P. Mol. Gen. Genet. (1986) [Pubmed]
  6. The Saccharomyces cerevisiae CKS1 gene, a homolog of the Schizosaccharomyces pombe suc1+ gene, encodes a subunit of the Cdc28 protein kinase complex. Hadwiger, J.A., Wittenberg, C., Mendenhall, M.D., Reed, S.I. Mol. Cell. Biol. (1989) [Pubmed]
  7. A fission yeast gene mapping close to suc1 encodes a protein containing two bromodomains. Aves, S.J., Hindley, J., Phear, G.A., Tongue, N. Mol. Gen. Genet. (1995) [Pubmed]
  8. The folding pathway of the cell-cycle regulatory protein p13suc1: clues for the mechanism of domain swapping. Schymkowitz, J.W., Rousseau, F., Irvine, L.R., Itzhaki, L.S. Structure (2000) [Pubmed]
  9. Sequence conservation provides the best prediction of the role of proline residues in p13suc1. Schymkowitz, J.W., Rousseau, F., Itzhaki, L.S. J. Mol. Biol. (2000) [Pubmed]
  10. Control over the onset of DNA synthesis in fission yeast. Simanis, V., Hayles, J., Nurse, P. Philos. Trans. R. Soc. Lond., B, Biol. Sci. (1987) [Pubmed]
  11. A study of integrative transformation in Schizosaccharomyces pombe. Grallert, B., Nurse, P., Patterson, T.E. Mol. Gen. Genet. (1993) [Pubmed]
  12. Leishmania mexicana p12cks1, a homologue of fission yeast p13suc1, associates with a stage-regulated histone H1 kinase. Mottram, J.C., Grant, K.M. Biochem. J. (1996) [Pubmed]
WikiGenes - Universities