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Gene Review

Ras64B  -  Ras oncogene at 64B

Drosophila melanogaster

Synonyms: BcDNA:RE36103, C-ras2, CG1167, D-ras-2, D-ras2, ...
 
 
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Disease relevance of Ras64B

 

High impact information on Ras64B

 

Biological context of Ras64B

  • In the case of Dras2, the nucleotide sequence fo the genomic clone was determined [6].
  • The Drosophila Ras2 and Rop gene pair: a dual homology with a yeast Ras-like gene and a suppressor of its loss-of-function phenotype [7].
  • The cellular signal transduction pathways by which C3G, a RAS family guanine nucleotide exchange factor, mediates v-crk transformation are not well understood [8].
  • The transcription start sites of the ras2 gene and the flanking transcription unit were determined by external primer extension with T4 DNA polymerase and by RNAase-protection assay and were found to be only 94 nucleotides apart [9].
  • We isolated and delimitated the Drosophila ras2 promoter region, determined its sequence and mapped the transcription units expressed in this region [9].
 

Anatomical context of Ras64B

  • Rop and Ras2, members of the Sec1 and Ras families, are localized in the outer membranes of labyrinthine channels and vesicles of Drosophila nephrocyte, the garland cell [10].
 

Associations of Ras64B with chemical compounds

  • In the yeast Saccharomyces cerevisiae, the RAS gene products serve as essential function by regulating cyclic adenosine monophosphate metabolism [11].
 

Other interactions of Ras64B

  • We have also established that the Rop and Ras2 genes are located within the 63E-64A genomic domain at 64A10,11 [12].
  • We describe the developmental effects of the expression of a normal and mutated Drosophila ras gene ras2 in transgenic Drosophila [13].
 

Analytical, diagnostic and therapeutic context of Ras64B

References

  1. Characterization and developmental expression of a Drosophila ras oncogene. Mozer, B., Marlor, R., Parkhurst, S., Corces, V. Mol. Cell. Biol. (1985) [Pubmed]
  2. Noonan syndrome and related disorders: dysregulated RAS-mitogen activated protein kinase signal transduction. Gelb, B.D., Tartaglia, M. Hum. Mol. Genet. (2006) [Pubmed]
  3. High-throughput retroviral tagging to identify components of specific signaling pathways in cancer. Mikkers, H., Allen, J., Knipscheer, P., Romeijn, L., Hart, A., Vink, E., Berns, A., Romeyn, L. Nat. Genet. (2002) [Pubmed]
  4. Photoreceptor cell differentiation requires regulated proteolysis of the transcriptional repressor Tramtrack. Li, S., Li, Y., Carthew, R.W., Lai, Z.C. Cell (1997) [Pubmed]
  5. JUN cooperates with the ETS domain protein pointed to induce photoreceptor R7 fate in the Drosophila eye. Treier, M., Bohmann, D., Mlodzik, M. Cell (1995) [Pubmed]
  6. The Drosophila ras oncogenes: structure and nucleotide sequence. Neuman-Silberberg, F.S., Schejter, E., Hoffmann, F.M., Shilo, B.Z. Cell (1984) [Pubmed]
  7. The Drosophila Ras2 and Rop gene pair: a dual homology with a yeast Ras-like gene and a suppressor of its loss-of-function phenotype. Salzberg, A., Cohen, N., Halachmi, N., Kimchie, Z., Lev, Z. Development (1993) [Pubmed]
  8. Activation of the Drosophila C3G leads to cell fate changes and overproliferation during development, mediated by the RAS-MAPK pathway and RAP1. Ishimaru, S., Williams, R., Clark, E., Hanafusa, H., Gaul, U. EMBO J. (1999) [Pubmed]
  9. A bidirectional promoter is regulating the Drosophila ras2 gene. Cohen, N., Salzberg, A., Lev, Z. Oncogene (1988) [Pubmed]
  10. Rop and Ras2, members of the Sec1 and Ras families, are localized in the outer membranes of labyrinthine channels and vesicles of Drosophila nephrocyte, the garland cell. Halachmi, N., Feldman, M., Kimchie, Z., Lev, Z. Eur. J. Cell Biol. (1995) [Pubmed]
  11. The ras oncogene--an important regulatory element in lower eucaryotic organisms. Gibbs, J.B., Marshall, M.S. Microbiol. Rev. (1989) [Pubmed]
  12. A genetic analysis of the 63E-64A genomic region of Drosophila melanogaster: identification of mutations in a replication factor C subunit. Harrison, S.D., Solomon, N., Rubin, G.M. Genetics (1995) [Pubmed]
  13. Expression of an activated ras gene causes developmental abnormalities in transgenic Drosophila melanogaster. Bishop, J.G., Corces, V.G. Genes Dev. (1988) [Pubmed]
 
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