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Gene Review

OSBPL3  -  oxysterol binding protein-like 3

Homo sapiens

Synonyms: KIAA0704, ORP-3, ORP3, OSBP-related protein 3, OSBP3, ...
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High impact information on OSBPL3


Biological context of OSBPL3


Anatomical context of OSBPL3


Associations of OSBPL3 with chemical compounds


Regulatory relationships of OSBPL3

  • Analysis of a chimeric ORP3:OSBP protein suggests that ligand binding by the C-terminal domain of OSBP induces allosteric changes that activate the N-terminal targeting modules of ORP3 [2].

Other interactions of OSBPL3

  • The ORP-1 and -2 mRNA expression levels were similar to or higher than that of OSBP while the ORP-3 to -6 mRNAs were detected at lower levels in specific tissues [5].
  • Here we performed basic characterization of subfamily III, which consists of three members: ORP3, ORP6, and ORP7 [3].

Analytical, diagnostic and therapeutic context of OSBPL3

  • To further characterize the gene, we cloned ORP3 cDNA from PCR products and identified multiple splice variants [6].


  1. ORP-3, a human oxysterol-binding protein gene differentially expressed in hematopoietic cells. Gregorio-King, C.C., Collier, G.R., McMillan, J.S., Waugh, C.M., McLeod, J.L., Collier, F.M., Kirkland, M.A. Blood (2001) [Pubmed]
  2. Targeting of OSBP-related protein 3 (ORP3) to endoplasmic reticulum and plasma membrane is controlled by multiple determinants. Lehto, M., Hynynen, R., Karjalainen, K., Kuismanen, E., Hyvärinen, K., Olkkonen, V.M. Exp. Cell Res. (2005) [Pubmed]
  3. Subfamily III of mammalian oxysterol-binding protein (OSBP) homologues: the expression and intracellular localization of ORP3, ORP6, and ORP7. Lehto, M., Tienari, J., Lehtonen, S., Lehtonen, E., Olkkonen, V.M. Cell Tissue Res. (2004) [Pubmed]
  4. The R-Ras interaction partner ORP3 regulates cell adhesion. Lehto, M., Mäyränpää, M.I., Pellinen, T., Ihalmo, P., Lehtonen, S., Kovanen, P.T., Groop, P.H., Ivaska, J., Olkkonen, V.M. J. Cell. Sci. (2008) [Pubmed]
  5. Family of human oxysterol binding protein (OSBP) homologues. A novel member implicated in brain sterol metabolism. Laitinen, S., Olkkonen, V.M., Ehnholm, C., Ikonen, E. J. Lipid Res. (1999) [Pubmed]
  6. ORP3 splice variants and their expression in human tissues and hematopoietic cells. Collier, F.M., Gregorio-King, C.C., Apostolopoulos, J., Walder, K., Kirkland, M.A. DNA Cell Biol. (2003) [Pubmed]
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