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Gene Review:

FDCSP - follicular dendritic cell secreted protein

Homo sapiens

Synonyms: C4orf7, FDC secreted protein, FDC-SP, Follicular dendritic cell secreted peptide, UNQ733/PRO1419

Marshall, A.J. et al., Nakamura, S. et al.

Marshall, Du, Draves, Shikishima, HayGlass, Clark,

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Disease relevance of C4orf7

We provide evidence that FDC-SP is posttranslationally modified and secreted and can bind to the surface of B lymphoma cells, but not T lymphoma cells, consistent with a function as a secreted mediator acting upon B cells [1].
In addition, FDC-SP is expressed in leukocyte-infiltrated tonsil crypts and by LPS- or Staphylococcus aureus Cowan strain 1-activated leukocytes, suggesting that FDC-SP can also be produced in response to innate immunity signals [1].

High impact information on C4orf7

Furthermore, we find that binding of FDC-SP to primary human B cells is markedly enhanced upon activation with the T-dependent activation signals such as anti-CD40 plus IL-4 [1].
Strikingly, FDC-SP is highly expressed in germinal center light zone, a pattern consistent with expression by FDC [1].
FDC-SP, a novel secreted protein expressed by follicular dendritic cells [1].
The FDC-SP gene lies on chromosome 4q13 adjacent to clusters of proline-rich salivary peptides and C-X-C chemokines [1].
Together our data identify FDC-SP as a unique secreted peptide with a distinctive expression pattern within the immune system and the ability to specifically bind to activated B cells [1].

Biological context of C4orf7

FDC-SP has a very restricted tissue distribution and is expressed by activated FDCs from tonsils and TNF-alpha-activated FDC-like cell lines, but not by B cell lines, primary germinal center B cells, or anti-CD40 plus IL-4-activated B cells [1].

Anatomical context of C4orf7

Identification of genes preferentially expressed in periodontal ligament: specific expression of a novel secreted protein, FDC-SP [2].
Since only normal tissue was examined, these findings suggest that FDC-SP plays an important but previously unsuspected role within oral connective tissue [2].

Other interactions of C4orf7

Also within this group is the gene for follicular dendritic cell secreted protein (FDC-SP), a small protein like statherin in saliva, not previously found in PDL [2].

References

FDC-SP, a novel secreted protein expressed by follicular dendritic cells. Marshall, A.J., Du, Q., Draves, K.E., Shikishima, Y., HayGlass, K.T., Clark, E.A. J. Immunol. (2002) [Pubmed]
Identification of genes preferentially expressed in periodontal ligament: specific expression of a novel secreted protein, FDC-SP. Nakamura, S., Terashima, T., Yoshida, T., Iseki, S., Takano, Y., Ishikawa, I., Shinomura, T. Biochem. Biophys. Res. Commun. (2005) [Pubmed]

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