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Gene Review

ARHGEF26  -  Rho guanine nucleotide exchange factor...

Homo sapiens

Synonyms: CSGEF, DKFZP434D146, HMFN1864, Rho guanine nucleotide exchange factor 26, SGEF, ...
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Disease relevance of SGEF


High impact information on SGEF

  • Full-length SGEF activated RhoG, but not Rac, when expressed in fibroblasts [3].
  • Scanning electron microscopy of fibroblasts demonstrated that SGEF induced dorsal ruffles that were morphologically similar to those generated by constitutively active RhoG, but not constitutively active Rac1 [3].
  • Transient expression of SGEF stimulated fibroblast uptake of 10-kDa dextran, a marker of macropinocytosis [3].
  • SGEF (SH3-containing Guanine Nucleotide Exchange Factor) is a RhoGEF of unknown function [3].
  • SGEF required its proline-rich amino-terminus to generate dorsal, but not lateral, membrane ruffles and a functional SH3 domain to colocalize with filamentous actin at sites of membrane protrusion [3].

Biological context of SGEF


Anatomical context of SGEF

  • We found the SGEF protein to be expressed in many established cell lines and highly expressed in human liver tissue [3].

Associations of SGEF with chemical compounds

  • The SGEF mRNA is widely expressed in human tissues, and the predicted 871-amino acid SGEF protein contains Dbl homology and pleckstrin homology domains as well as an N-terminal proline-rich domain, a C-terminal Src homology 3 domain, and two nuclear localization signals [2].

Other interactions of SGEF

  • SGEF, a RhoG guanine nucleotide exchange factor that stimulates macropinocytosis [3].
  • One included Neogenin, WASF1 and SGEF genes, which may have a role in differentiation or development [4].


  1. Differential activation and function of Rho GTPases during Salmonella-host cell interactions. Patel, J.C., Gal??n, J.E. J. Cell Biol. (2006) [Pubmed]
  2. Isolation of the novel human guanine nucleotide exchange factor Src homology 3 domain-containing guanine nucleotide exchange factor (SGEF) and of C-terminal SGEF, an N-terminally truncated form of SGEF, the expression of which is regulated by androgen in prostate cancer cells. Qi, H., Fournier, A., Grenier, J., Fillion, C., Labrie, Y., Labrie, C. Endocrinology (2003) [Pubmed]
  3. SGEF, a RhoG guanine nucleotide exchange factor that stimulates macropinocytosis. Ellerbroek, S.M., Wennerberg, K., Arthur, W.T., Dunty, J.M., Bowman, D.R., DeMali, K.A., Der, C., Burridge, K. Mol. Biol. Cell (2004) [Pubmed]
  4. Identification of novel E2F1 target genes regulated in cell cycle-dependent and independent manners. Iwanaga, R., Komori, H., Ishida, S., Okamura, N., Nakayama, K., Nakayama, K.I., Ohtani, K. Oncogene (2006) [Pubmed]
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