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Gene Review

CHIC2  -  cysteine-rich hydrophobic domain 2

Homo sapiens

Synonyms: BTL, BrX-like translocated in leukemia, Cysteine-rich hydrophobic domain-containing protein 2
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Disease relevance of CHIC2


High impact information on CHIC2


Analytical, diagnostic and therapeutic context of CHIC2

  • The c-Myb protein (75 kDa) was detected in Pr2181 but not as a clear band in BLT2, while BTL-PC3 exhibited a 65-kDa c-Myb band in immunoprecipitation tests with anti-Myb antiserum [3].


  1. CHIC2 deletion, a surrogate for FIP1L1-PDGFRA fusion, occurs in systemic mastocytosis associated with eosinophilia and predicts response to imatinib mesylate therapy. Pardanani, A., Ketterling, R.P., Brockman, S.R., Flynn, H.C., Paternoster, S.F., Shearer, B.M., Reeder, T.L., Li, C.Y., Cross, N.C., Cools, J., Gilliland, D.G., Dewald, G.W., Tefferi, A. Blood (2003) [Pubmed]
  2. A new family of small, palmitoylated, membrane-associated proteins, characterized by the presence of a cysteine-rich hydrophobic motif. Cools, J., Mentens, N., Marynen, P. FEBS Lett. (2001) [Pubmed]
  3. A spontaneous internal deletion of the c-myb protooncogene enhances transcriptional activation in bovine T lymphoma cells. Ishiguro, N., Ohzono, T., Shinagawa, T., Horiuchi, M., Shinagawa, M. J. Biol. Chem. (1994) [Pubmed]
  4. Fusion of a novel gene, BTL, to ETV6 in acute myeloid leukemias with a t(4;12)(q11-q12;p13). Cools, J., Bilhou-Nabera, C., Wlodarska, I., Cabrol, C., Talmant, P., Bernard, P., Hagemeijer, A., Marynen, P. Blood (1999) [Pubmed]
  5. Dynamics of chemosensitivity and chromosomal instability in recurrent glioblastoma. Spiegl-Kreinecker, S., Pirker, C., Marosi, C., Buchroithner, J., Pichler, J., Silye, R., Fischer, J., Micksche, M., Berger, W. Br. J. Cancer (2007) [Pubmed]
  6. Cough and hypereosinophilia due to FIP1L1-PDGFRA fusion gene with tyrosine kinase activity. Chung, K.F., Hew, M., Score, J., Jones, A.V., Reiter, A., Cross, N.C., Bain, B.J. Eur. Respir. J. (2006) [Pubmed]
  7. Systemic mastocytosis (SM) associated with chronic eosinophilic leukemia (SM-CEL): detection of FIP1L1/PDGFRalpha, classification by WHO criteria, and response to therapy with imatinib. Florian, S., Esterbauer, H., Binder, T., Müllauer, L., Haas, O.A., Sperr, W.R., Sillaber, C., Valent, P. Leuk. Res. (2006) [Pubmed]
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