Gene Review:
CHIC2 - cysteine-rich hydrophobic domain 2
Homo sapiens
Synonyms:
BTL, BrX-like translocated in leukemia, Cysteine-rich hydrophobic domain-containing protein 2
- CHIC2 deletion, a surrogate for FIP1L1-PDGFRA fusion, occurs in systemic mastocytosis associated with eosinophilia and predicts response to imatinib mesylate therapy. Pardanani, A., Ketterling, R.P., Brockman, S.R., Flynn, H.C., Paternoster, S.F., Shearer, B.M., Reeder, T.L., Li, C.Y., Cross, N.C., Cools, J., Gilliland, D.G., Dewald, G.W., Tefferi, A. Blood (2003)
- A new family of small, palmitoylated, membrane-associated proteins, characterized by the presence of a cysteine-rich hydrophobic motif. Cools, J., Mentens, N., Marynen, P. FEBS Lett. (2001)
- A spontaneous internal deletion of the c-myb protooncogene enhances transcriptional activation in bovine T lymphoma cells. Ishiguro, N., Ohzono, T., Shinagawa, T., Horiuchi, M., Shinagawa, M. J. Biol. Chem. (1994)
- Fusion of a novel gene, BTL, to ETV6 in acute myeloid leukemias with a t(4;12)(q11-q12;p13). Cools, J., Bilhou-Nabera, C., Wlodarska, I., Cabrol, C., Talmant, P., Bernard, P., Hagemeijer, A., Marynen, P. Blood (1999)
- Dynamics of chemosensitivity and chromosomal instability in recurrent glioblastoma. Spiegl-Kreinecker, S., Pirker, C., Marosi, C., Buchroithner, J., Pichler, J., Silye, R., Fischer, J., Micksche, M., Berger, W. Br. J. Cancer (2007)
- Cough and hypereosinophilia due to FIP1L1-PDGFRA fusion gene with tyrosine kinase activity. Chung, K.F., Hew, M., Score, J., Jones, A.V., Reiter, A., Cross, N.C., Bain, B.J. Eur. Respir. J. (2006)
- Systemic mastocytosis (SM) associated with chronic eosinophilic leukemia (SM-CEL): detection of FIP1L1/PDGFRalpha, classification by WHO criteria, and response to therapy with imatinib. Florian, S., Esterbauer, H., Binder, T., Müllauer, L., Haas, O.A., Sperr, W.R., Sillaber, C., Valent, P. Leuk. Res. (2006)
