High impact information on Optc

• The Optc gene was less than 4 kb from the Prelp gene [1].
• RESULTS: The Optc gene was localized to mouse chromosome 1 at 74.3 cM and consisted of seven exons spanning 10 kb [1].
• Opticin may represent a marker for ciliary body differentiation [1].
• METHODS: Expressed sequence tags (ESTs) to mouse opticin were identified and the full-length sequence obtained after PCR reactions using a 15-day-postconception (dpc) whole-mouse embryo cDNA library [1].
• In situ hybridization localized opticin mRNA exclusively to the presumptive ciliary body during development and to the nonpigmented ciliary epithelium of the adult mouse eye [1].

Biological context of Optc

• Synteny and the expression patterns of these genes suggest that the dspg3l and optcl are the orthologs to the mammalian dspg3 and optc genes, respectively [2].

Anatomical context of Optc

• Like epiphycans in other species, dspg3l is exclusively expressed in the developing notochord and cartilage. optcl is expressed transiently in the developing nervous system, eyes and somites much like opticin [2].

Associations of Optc with chemical compounds

• Epiphycan (DSPG3) and opticin are two class III small leucine-rich proteoglycans (SLRP) [2].

Analytical, diagnostic and therapeutic context of Optc

• The mouse chromosomal localization of Optc was determined by radiation hybrid mapping and its genomic structure determined using an Optc-containing BAC clone [1].

References