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Gene Review

OPTC  -  opticin

Homo sapiens

Synonyms: OPT, Oculoglycan, Opticin
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Disease relevance of OPTC


High impact information on OPTC


Biological context of OPTC

  • The coding sequence of OPTC was amplified by PCR from genomic DNA of POAG patients, followed by SSCP, DHPLC and DNA sequencing [5].
  • Synteny and the expression patterns of these genes suggest that the dspg3l and optcl are the orthologs to the mammalian dspg3 and optc genes, respectively [6].

Anatomical context of OPTC

  • Western blotting with a specific peptide antibody detects Optc in iris, ciliary body and retina in the human eye and suggests that the protein is post-translationally modified [7].
  • In situ hybridisation studies have previously demonstrated opticin expression by the posterior non-pigmented ciliary epithelium [8].
  • Opticin and GH were also colocalized in the retina in retinal ganglion cells [9].
  • The current study was conducted to investigate the possibility that opticin binds retinal GH in the vitreous of the chick embryo [9].
  • RESULTS: Opticin was immunolocalised to the basal cell surface and basement membrane material of the non-pigmented CBE in nine donor eyes as well as four hyperplastic lesions of the CBE (Fuchs's adenoma) [2].

Associations of OPTC with chemical compounds


Other interactions of OPTC


Analytical, diagnostic and therapeutic context of OPTC


  1. Protein localization in the human eye and genetic screen of opticin. Friedman, J.S., Faucher, M., Hiscott, P., Biron, V.L., Malenfant, M., Turcotte, P., Raymond, V., Walter, M.A. Hum. Mol. Genet. (2002) [Pubmed]
  2. Neoplastic transformation of ciliary body epithelium is associated with loss of opticin expression. Assheton, D.C., Guerin, E.P., Sheridan, C.M., Bishop, P.N., Hiscott, P.S. The British journal of ophthalmology (2007) [Pubmed]
  3. Characterization of opticin and evidence of stable dimerization in solution. Le Goff, M.M., Hindson, V.J., Jowitt, T.A., Scott, P.G., Bishop, P.N. J. Biol. Chem. (2003) [Pubmed]
  4. Identification in vitreous and molecular cloning of opticin, a novel member of the family of leucine-rich repeat proteins of the extracellular matrix. Reardon, A.J., Le Goff, M., Briggs, M.D., McLeod, D., Sheehan, J.K., Thornton, D.J., Bishop, P.N. J. Biol. Chem. (2000) [Pubmed]
  5. Evaluation of the OPTC gene in primary open angle glaucoma: functional significance of a silent change. Acharya, M., Mookherjee, S., Bhattacharjee, A., Thakur, S.K., Bandyopadhyay, A.K., Sen, A., Chakrabarti, S., Ray, K. BMC Mol. Biol. (2007) [Pubmed]
  6. Molecular cloning and expression of two small leucine-rich proteoglycan (SLRP) genes, dspg3l and optcl, in zebrafish. Zhou, W., Shirabe, K., Kuwada, J.Y. Gene Expr. Patterns (2006) [Pubmed]
  7. Cloning, modeling, and chromosomal localization for a small leucine-rich repeat proteoglycan (SLRP) family member expressed in human eye. Hobby, P., Wyatt, M.K., Gan, W., Bernstein, S., Tomarev, S., Slingsby, C., Wistow, G. Mol. Vis. (2000) [Pubmed]
  8. Immunolocalisation of opticin in the human eye. Ramesh, S., Bonshek, R.E., Bishop, P.N. The British journal of ophthalmology. (2004) [Pubmed]
  9. Opticin binds retinal growth hormone in the embryonic vitreous. Sanders, E.J., Walter, M.A., Parker, E., Arámburo, C., Harvey, S. Invest. Ophthalmol. Vis. Sci. (2003) [Pubmed]
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