The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Gene Review

DMD  -  dystrophin

Bos taurus

This record was replaced with 540755.
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of DMD

  • MDCK cells were infected with influenza virus and the virus was raised in the presence of various amounts of DMDP [1].

High impact information on DMD

  • DMDP did cause some inhibition of mannose incorporation into the lipid-linked monosaccharides, but incorporation into lipid-linked oligosaccharides was not greatly affected, and incorporation into protein was stimulated [1].
  • 2,5-Dihydroxymethyl-3,4-dihydroxypyrrolidine (DMDP) is a pyrrolidine alkaloid that was isolated from the plant, Lonchocarpus sericeus [1].
  • In the present study, DMDP was tested as an inhibitor of glycoprotein processing [1].
  • DMDP did not inhibit the incorporation of [3H]leucine into protein in MDCK cells, nor did it inhibit virus production as measured by plaque counts or hemagglutination assays [1].
  • We conclude that adjuvant activity (and memory formation) of liposomes with antigen exposed on their surface occurs irrespective of the presence or absence of splenic macrophages, and that DMDP liposomes could be useful in drug targeting with antigenic liposomes [2].

Anatomical context of DMD

  • In digestion trial 2, 3% NH3-treated cornstalks produced higher (P greater than .01) DMD, DM intake and cell wall digestibility than untreated cornstalks [3].
  • Macrophages in the murine spleen were eliminated by the intravenous administration of dichloromethylene-diphosphonate (DMDP) encapsulated in liposomes [2].

Associations of DMD with chemical compounds


  1. The pyrrolidine alkaloid, 2,5-dihydroxymethyl-3,4-dihydroxypyrrolidine, inhibits glycoprotein processing. Elbein, A.D., Mitchell, M., Sanford, B.A., Fellows, L.E., Evans, S.V. J. Biol. Chem. (1984) [Pubmed]
  2. Immunomodulation with liposomes: the immune response elicited by liposomes with entrapped dichloromethylene-diphosphonate and surface-associated antigen or hapten. Claassen, E., Kors, N., van Rooijen, N. Immunology (1987) [Pubmed]
  3. Ammonia treatment of corn plant residues: digestibilities and growth rates. Paterson, J.A., Klopfenstein, T.J., Britton, R.A. J. Anim. Sci. (1981) [Pubmed]
  4. Periparturient changes in intake, ruminal capacity, and digestive characteristics in beef cows consuming alfalfa hay. Stanley, T.A., Cochran, R.C., Vanzant, E.S., Harmon, D.L., Corah, L.R. J. Anim. Sci. (1993) [Pubmed]
  5. Polyhydroxylated pyrrolidine and piperidine alkaloids from Adenophora triphylla var. japonica (Campanulaceae). Asano, N., Nishida, M., Miyauchi, M., Ikeda, K., Yamamoto, M., Kizu, H., Kameda, Y., Watson, A.A., Nash, R.J., Fleet, G.W. Phytochemistry (2000) [Pubmed]
  6. Characterization of an in vitro model of calcification in retinal pigmented epithelial cells. Sugitani, H., Wachi, H., Murata, H., Sato, F., Mecham, R.P., Seyama, Y. J. Atheroscler. Thromb. (2003) [Pubmed]
WikiGenes - Universities