Disease relevance of DMD

• MDCK cells were infected with influenza virus and the virus was raised in the presence of various amounts of DMDP [1].

High impact information on DMD

• DMDP did cause some inhibition of mannose incorporation into the lipid-linked monosaccharides, but incorporation into lipid-linked oligosaccharides was not greatly affected, and incorporation into protein was stimulated [1].
• 2,5-Dihydroxymethyl-3,4-dihydroxypyrrolidine (DMDP) is a pyrrolidine alkaloid that was isolated from the plant, Lonchocarpus sericeus [1].
• In the present study, DMDP was tested as an inhibitor of glycoprotein processing [1].
• DMDP did not inhibit the incorporation of [3H]leucine into protein in MDCK cells, nor did it inhibit virus production as measured by plaque counts or hemagglutination assays [1].
• We conclude that adjuvant activity (and memory formation) of liposomes with antigen exposed on their surface occurs irrespective of the presence or absence of splenic macrophages, and that DMDP liposomes could be useful in drug targeting with antigenic liposomes [2].

Anatomical context of DMD

• In digestion trial 2, 3% NH3-treated cornstalks produced higher (P greater than .01) DMD, DM intake and cell wall digestibility than untreated cornstalks [3].
• Macrophages in the murine spleen were eliminated by the intravenous administration of dichloromethylene-diphosphonate (DMDP) encapsulated in liposomes [2].

Associations of DMD with chemical compounds

• Ruminal VFA, pH, NH3, and total tract DM digestibility (DMD) were measured during three 7-d periods (average of 58 d before calving, 16 d before calving, and 25 d after calving) [4].
• Adenophora triphylla var. japonica (Campanulaceae) yielded two new alkaloids, the 6-C-butyl derivative of 2R,5R-bis(hydroxymethyl)-3R,4R-dihydroxypyrrolidine (DMDP) and alpha-1-C-ethyl-fagomine, together with the known alkaloids 1,4-dideoxy-1,4-imino-D-arabinitol, 1-deoxynojirimycin, and 1-deoxymannojirimycin [5].
• The Pi-induced calcification, as assessed by the o-cresolphthalein complexone method, Goldenbergs method, and von Kossa staining, was completely inhibited by treatment with clodronate (DMDP) and phosphonoformic acid (PFA) and was weakly suppressed by treatment with levamisole [6].

References