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MeSH Review:

Campanulaceae

Asano, N. et al., Ishimaru, K. et al., Wu, B. et al., Lee, K.J. et al., Lee, K.J. et al., et al.

Asano, Nishida, Miyauchi, Ikeda, Yamamoto, Kizu, Kameda, Watson, Nash, Fleet, Ishimaru, Osabe, Yan, Fujioka, Mihashi, Tanaka, Okinaka, Shimada, Nakano-Shimada, Ohbayashi, Kiyokawa, Kikuchi,

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Disease relevance of Campanulaceae

DC (Campanulaceae), on the progress of acute carbon tetrachloride (CCl4)-induced hepatic fibrosis were investigated in the rat [1].

High impact information on Campanulaceae

DC (Campanulaceae), Changkil saponins (CKS), on the tert-butyl hydroperoxide (t-BHP)-induced oxidative injury (hepatotoxicity) in cultured rat primary hepatocytes and in rat livers [2].
Cirsium purpuratum and Campanula punctata ssp. hondoensis formed single structural types of Arum- and Paris-type, respectively, whereas P. cuspidatum and Clematis stans formed both Arum- and Paris-type morphologies [3].
Two polyacetylene glycosides, lobetyol 9-O-glc(6)-(1)rha (pratialin-A) and lobetyol 9-O-glc(6)-(1)glc(6)-(1)glc (pratialin-B), were isolated from Pratia nummularia (Campanulaceae) callus and hairy root cultures and their chemical structures were determined by analysis of spectroscopic data [4].
DC (Campanulaceae) on carbon tetrachloride (CC14)-induced hepatotoxicity and the possible mechanisms involved in this protection were investigated in mice [5].
DC (Campanulaceae), Changkil (CK), on acetaminophen (APAP)-induced hepatotoxicities and the possible protective mechanisms involved were investigated in mice [6].

Anatomical context of Campanulaceae

DC (Campanulaceae), Changkil saponins (CKS), inhibited cyclooxygenase-2 (COX-2) expression in cultured lipopolysaccharide-activated macrophages [7].

Associations of Campanulaceae with chemical compounds

Four new phenylpropanoid derivatives, barbatosides A-D, and a new catechin, barbatoflavan, were isolated from the whole plant of Campanula barbata L [8].
Polyhydroxylated pyrrolidine and piperidine alkaloids from Adenophora triphylla var. japonica (Campanulaceae) [9].
Homonojirimycin analogues and their glucosides from Lobelia sessilifolia and Adenophora spp. (Campanulaceae) [10].
Adenophora triphylla var. japonica (Campanulaceae) yielded two new alkaloids, the 6-C-butyl derivative of 2R,5R-bis(hydroxymethyl)-3R,4R-dihydroxypyrrolidine (DMDP) and alpha-1-C-ethyl-fagomine, together with the known alkaloids 1,4-dideoxy-1,4-imino-D-arabinitol, 1-deoxynojirimycin, and 1-deoxymannojirimycin [9].
Selective accumulation of delphinidin derivatives in tobacco using a putative flavonoid 3',5'-hydroxylase cDNA from Campanula medium [11].

Gene context of Campanulaceae

(Campanulaceae), showed good inhibitory activity against both PGHS isoenzymes [12].

References

Suppressive effects of Platycodon grandiflorum on the progress of carbon tetrachloride-induced hepatic fibrosis. Lee, K.J., Kim, J.Y., Jung, K.S., Choi, C.Y., Chung, Y.C., Kim, D.H., Jeong, H.G. Arch. Pharm. Res. (2004) [Pubmed]
Protective effect of saponins derived from roots of Platycodon grandiflorum on tert-butyl hydroperoxide-induced oxidative hepatotoxicity. Lee, K.J., Choi, C.Y., Chung, Y.C., Kim, Y.S., Ryu, S.Y., Roh, S.H., Jeong, H.G. Toxicol. Lett. (2004) [Pubmed]
Arbuscular mycorrhizal colonization of the dominant plant species in primary successional volcanic deserts on the Southeast slope of Mount Fuji. Wu, B., Isobe, K., Ishii, R. Mycorrhiza (2004) [Pubmed]
Polyacetylene glycosides from Pratia nummularia cultures. Ishimaru, K., Osabe, M., Yan, L., Fujioka, T., Mihashi, K., Tanaka, N. Phytochemistry (2003) [Pubmed]
Protective effect of Platycodi radix on carbon tetrachloride-induced hepatotoxicity. Lee, K.J., Jeong, H.G. Food Chem. Toxicol. (2002) [Pubmed]
Hepatoprotective effects of Platycodon grandiflorum on acetaminophen-induced liver damage in mice. Lee, K.J., You, H.J., Park, S.J., Kim, Y.S., Chung, Y.C., Jeong, T.C., Jeong, H.G. Cancer Lett. (2001) [Pubmed]
Inhibitory Effect of the Saponins Derived from Roots of Platycodon grandiflorum on Carrageenan-Induced Inflammation. Kim, J.Y., Hwang, Y.P., Kim, D.H., Han, E.H., Chung, Y.C., Roh, S.H., Jeong, H.G. Biosci. Biotechnol. Biochem. (2006) [Pubmed]
Flavonoids and phenylpropanoid derivatives from Campanula barbata. Cuendet, M., Potterat, O., Hostettmann, K. Phytochemistry (2001) [Pubmed]
Polyhydroxylated pyrrolidine and piperidine alkaloids from Adenophora triphylla var. japonica (Campanulaceae). Asano, N., Nishida, M., Miyauchi, M., Ikeda, K., Yamamoto, M., Kizu, H., Kameda, Y., Watson, A.A., Nash, R.J., Fleet, G.W. Phytochemistry (2000) [Pubmed]
Homonojirimycin analogues and their glucosides from Lobelia sessilifolia and Adenophora spp. (Campanulaceae). Ikeda, K., Takahashi, M., Nishida, M., Miyauchi, M., Kizu, H., Kameda, Y., Arisawa, M., Watson, A.A., Nash, R.J., Fleet, G.W., Asano, N. Carbohydr. Res. (2000) [Pubmed]
Selective accumulation of delphinidin derivatives in tobacco using a putative flavonoid 3',5'-hydroxylase cDNA from Campanula medium. Okinaka, Y., Shimada, Y., Nakano-Shimada, R., Ohbayashi, M., Kiyokawa, S., Kikuchi, Y. Biosci. Biotechnol. Biochem. (2003) [Pubmed]
Prostaglandin-H-synthase (PGHS)-1 and -2 microtiter assays for the testing of herbal drugs and in vitro inhibition of PGHS-isoenzyms by polyunsaturated fatty acids from Platycodi radix. Reininger, E.A., Bauer, R. Phytomedicine (2006) [Pubmed]

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