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Chemical Compound Review

CHEMBL80254     (2R,3R,4R)-2- (hydroxymethyl)pyrrolidine- 3...

Synonyms: SureCN143519, D1542_SIGMA, CHEBI:222938, CCG-204461, Lopac0_000366, ...
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High impact information on AIDS001116


Biological context of AIDS001116


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Analytical, diagnostic and therapeutic context of AIDS001116

  • A high speed, selective, and robust capillary electrophoresis (CE) method with high capacity was developed and validated for determination of assay of 1,4-dideoxy-1,4-imino-D-arabinitol in active pharmaceutical ingredients, solutions, and tablets during the development work at preclinical and Phase I and II clinical studies [8].


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  2. Diverse effects of two allosteric inhibitors on the phosphorylation state of glycogen phosphorylase in hepatocytes. Latsis, T., Andersen, B., Agius, L. Biochem. J. (2002) [Pubmed]
  3. Regioselective and diastereoselective amination of polybenzyl ethers using chlorosulfonyl isocyanate: total syntheses of 1,4-dideoxy-1,4-imino-D-arabinitol and (-)-lentiginosine. Kim, I.S., Zee, O.P., Jung, Y.H. Org. Lett. (2006) [Pubmed]
  4. Use of the glucosidase inhibitor 1,4-dideoxy-1,4-imino-D-arabinitol as a probe to investigate hypertrehalosemic hormone-mediated change in carbohydrate and lipid metabolism in the cockroach, Periplaneta americana. Oguri, E., Steele, J.E. Arch. Insect Biochem. Physiol. (2006) [Pubmed]
  5. Pharmacokinetics and anti-hyperglycaemic efficacy of a novel inhibitor of glycogen phosphorylase, 1,4-dideoxy-1,4-imino-d- arabinitol, in glucagon-challenged rats and dogs and in diabetic ob/ob mice. Mackay, P., Ynddal, L., Andersen, J.V., McCormack, J.G. Diabetes, obesity & metabolism. (2003) [Pubmed]
  6. Polyhydroxylated pyrrolidine and piperidine alkaloids from Adenophora triphylla var. japonica (Campanulaceae). Asano, N., Nishida, M., Miyauchi, M., Ikeda, K., Yamamoto, M., Kizu, H., Kameda, Y., Watson, A.A., Nash, R.J., Fleet, G.W. Phytochemistry (2000) [Pubmed]
  7. Synthesis of naturally occurring iminosugars from D-fructose by the use of a zinc-mediated fragmentation reaction. Lauritsen, A., Madsen, R. Org. Biomol. Chem. (2006) [Pubmed]
  8. Development and validation of a capillary electrophoresis-indirect photometric detection method for the determination of the non-UV-absorbing 1,4-dideoxy-1,4-imino-D-arabinitol in active pharmaceutical ingredients, solutions and tablets using an internal standard. Jamali, B., Nielsen, H.M. Journal of chromatography. A. (2003) [Pubmed]
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