Disease relevance of AIF1

• Peritoneal macrophages from endometriosis patients secreted more AIF-1 than those from unaffected women (P < 0.05) [1].

High impact information on AIF1

• Expression of allograft inflammatory factor-1 in human eutopic endometrium and endometriosis: possible association with progression of endometriosis [1].
• AIF-1 release from macrophages was stimulated by IL-1beta (P < 0.01) and interferon-gamma (P < 0.05) [1].
• AIF-1 derived from peritoneal macrophages may also possibly play a significant role in the pathophysiology and progression of endometriosis [1].
• Expression has also been shown in human placentas and bovine embryos, suggesting that AIF-1 may be involved in reproductive function [1].
• AIF-1 protein was present in greater amounts in peritoneal fluid from patients with endometriosis than in women without it (P < 0.01), and its concentration correlated with the Revised American Society for Reproductive Medicine score (rs = 0.693; P < 0.0001) [1].

Biological context of AIF1

• AIF-1 mRNA was present in developing placenta through Gestation Day 36, and abundant levels were observed in adult bovine spleen and lung [2].
• These results demonstrate for the first time that AIF-1 is expressed in eutopic endometrium and endometriotic tissue, suggesting that AIF-1 is one cytokine in the local network involved in the onset of menstruation [1].
• Daintain is highly similar in amino acid sequence to allograft inflammatory factor-1 (AIF-1) [3].

Analytical, diagnostic and therapeutic context of AIF1

• RT-PCR, Western blot analysis, and immunohistochemistry showed that AIF-1 mRNA and protein were expressed both in eutopic endometrium and in endometriotic tissue [1].
• Allograft inflammatory factor-1 (AIF-1) is a cytokine originally identified in rat cardiac allografts with chronic rejection [1].

References