Disease relevance of Reproductive Medicine

• AIF-1 protein was present in greater amounts in peritoneal fluid from patients with endometriosis than in women without it (P < 0.01), and its concentration correlated with the Revised American Society for Reproductive Medicine score (rs = 0.693; P < 0.0001) [1].
• The reproductive health of women with von Willebrand Disease unresponsive to DDAVP: results of an international survey. On behalf of the Subcommittee on von Willebrand Factor of the Scientific and Standardization Committee of the ISTH [2].
• While there is substantial evidence of the importance of endogenous and exogenous estrogen in reproductive health and chronic disease, there is little consideration of androgens in women's health [3].
• DESIGN: Focus group meetings with reproductive health experts, semistructured interviews with infertility patients, and content analysis of an infertility message board to determine content domains of the CD-ROM [4].
• Dietary soy intake is associated with protection from breast cancer, but questions persist on the potential risks of the major soy isoflavone genistein (GEN) on female reproductive health [5].

Psychiatry related information on Reproductive Medicine

• METHODS: A total of 230 9th and 11th graders at a Colombian high school (69% of enrolled students) were anonymously surveyed about selected reproductive health behaviors using the Centers for Disease Control and Prevention's self-administered Youth Risk Behavior Survey. RESULTS: The response rate was >90% [6].

High impact information on Reproductive Medicine

• Although there are specific challenges to using genetic approaches in reproductive medicine, the following report summarizes mapping efforts for three diseases: adrenal hypoplasia congenita, hypergonadotropic ovarian failure, and polycystic ovary syndrome [7].
• Estrogen replacement therapy is one of the most controversial issues in the field of reproductive medicine [8].
• This review appraises current knowledge with a focus on the questionable basis for using androgen therapy to improve male reproductive health during aging [9].
• The dynamic effects of hormones on seizure expression and of seizures on reproductive health complicate the management of epilepsy in women [10].
• CONCLUSIONS: Men with CF desire more sexual and reproductive health information [11].

Chemical compound and disease context of Reproductive Medicine

• However, due to a lack of information for GPs about some areas of male sexual and reproductive health, e.g., androgen deficiency and male infertility, a case based practical approach to GP education was recommended [12].
• Factors associated with the reproductive health risk behavior of high school students in the Republic of the Marshall Islands [13].
• Infertility is a sad reality and it is now evident that several aspects of male reproductive health have changed for the worse over the past 30-50 years. para-nonylphenol (p-NP), an environmental toxicant with oestrogenic properties, was tested for its effect on male fertility potential [14].

Biological context of Reproductive Medicine

• The realization that estrogens are essential for proper maintenance of spermatogenesis, as well as growing evidence pointing to the deleterious effects of estrogen-like chemicals on male reproductive health, has made it imperative to dissect the role estrogens play in the male [15].
• CONTEXT: Despite its frequency, the polycystic ovary syndrome (PCOS) is still a difficult diagnosis in endocrinology, gynecology, and reproductive medicine [16].
• The authors examined the effects of caffeine consumption on waiting time to conception in the Reproductive Health Study, a retrospective study of 1,430 non-contracepting, parous women interviewed between July 1989 and June 1990 at Fishkill, New York, and Burlington, Vermont. Information was obtained on 2,501 pregnancies since 1980 [17].
• Maternal vitamin A or beta-carotene supplementation resulted in a reduction in the prevalence of selected illness symptoms during late pregnancy, at the time of birth and during 6 mo postpartum, suggesting that a diet adequate in vitamin A may be important for improving women's reproductive health [18].
• It was concluded that induction of luteolysis with PGF2 alpha in lactating dairy cattle with unobserved estrus and a palpable functional CL will be an effective addition to reproductive health programs [19].

Anatomical context of Reproductive Medicine

• A combination of immature oocyte cryopreservation for later maturation and IVF will provide the opportunity to establish oocyte banks and help overcome some of the practical and ethical dilemmas that are currently shadowing the field of reproductive medicine [20].
• Hormonally active chemicals in the environment such as DDT have been associated with declining male reproductive health, especially semen quality [21].

Associations of Reproductive Medicine with chemical compounds

• Therefore, numerous potential agonists/antagonists working together through several steroid-dependent signalling pathways could prove to be hazardous to human reproductive health [22].
• These reproducible results indicate that toxaphene can disturb hormonal signals mediated by the ER and suggest that these environmental chemicals have potential endocrine disrupting activities which may affect the reproductive health and increase the risk of carcinogenesis [23].
• METHODS: Serum DDT/DDE was analyzed in 466 nonsmoking, nulliparous women recruited from Anhui province in China between 1996 and 1998 as part of a reproductive health study of textile workers [24].
• Serum levels of testosterone do not provide evidence of selection bias in studies of male reproductive health [25].
• Scientific and public concern exists about potential reproductive health effects of persistent chlorinated organic chemicals, such as polychlorinated biphenyls (PCBs), dichlorodiphenyltrichloroethane (DDT), and dichlorodiphenyldichloroethylene (DDE, the most stable daughter compound of DDT) [26].

Gene context of Reproductive Medicine

• Prolactin and reproductive medicine [27].
• Inhibin, activin, and follistatin in reproductive medicine [28].
• Since the PR is essential for regulating key female reproductive processes, such as uterine proliferation, implantation, and maintenance of pregnancy, its increased expression suggests that soy phytoestrogen exposure during reproductive development may have long-term reproductive health consequences [29].
• Information concerning the reproductive health of women with CF has been limited to small or single-center studies [30].
• Fish consumption and other characteristics of reproductive-aged Michigan anglers--a potential population for studying the effects of consumption of Great Lakes fish on reproductive health [31].

Analytical, diagnostic and therapeutic context of Reproductive Medicine

• OBJECTIVE: To critically appraise the content of the American Society for Reproductive Medicine (ASRM)/Society for Reproductive Technology (SART) Registry [32].
• The objectives of this study were to determine whether flight attendants are more likely than teachers (comparison group) to experience circadian disruption, as measured by melatonin production, and to identify metrics of circadian disruption for epidemiologic studies of reproductive health in which biomonitoring is infeasible [33].
• To gain insight into the role of ovarian biopsy in reproductive medicine, we conducted a cross-sectional study in infertile patients with ovarian dysfunction and correlated follicle stimulating hormone (FSH) and estradiol serum concentrations with ovarian follicular counts [34].
• The July 1989 US Supreme Court decision in Webster v Reproductive Health Services restricts both women's access to legal abortion and physicians' latitude when performing abortions [35].

References