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Chemical Compound Review

calphostin C     1-[3,10-dihydroxy-12-[2-(4...

Synonyms: AG-K-64299, KBioGR_000240, KBioSS_000240, ACMC-20d0wl, C6303_SIGMA, ...
 
 
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Disease relevance of Ucn 1028 C

 

High impact information on Ucn 1028 C

  • The protein kinase C (PKC) inhibitor calphostin C prevented the stimulatory effect [6].
  • This effect can be reversed by the simultaneous incubation of PDGF-BB in the presence of calphostin C, a potent and selective inhibitor of protein kinase C. In contrast, incubation of cells in the presence of bFGF potentiates IL-1beta-induced production of NO and is functionally associated with an increased rate of apoptosis of mesangial cells [7].
  • Studies with the protein kinase C inhibitor, Calphostin C, suggest that the inhibition of reactive oxygen species release and lipid oxidation is due to an inhibition of protein kinase C activity by alpha tocopherol [8].
  • The participation of protein kinase C in the Rab4 regulation by CCK was confirmed by calphostin C pretreatment of acini [9].
  • Consistent with this possibility, engagement of CD151 by the substrate-adsorbed anti-CD151 mAb induced prominent Cdc42-dependent filopodial extension, which along with E-cadherin puncta formation, was strongly inhibited by calphostin C, a protein kinase C (PKC) inhibitor [10].
 

Chemical compound and disease context of Ucn 1028 C

  • Pertussis toxin, which inactivates Gi, and calphostin C, a protein kinase C inhibitor, each partially inhibited calcitonin-induced Shc tyrosine phosphorylation, Shc-Grb2 association, and Erk1/2 phosphorylation [11].
  • Pretreatment with 1-octadecyl-2-methyl-rac-glycero-3-phosphocholine and calphostin C prevented the activation of ribose PRPP synthetase and PRPP pyrophosphatase as well as increase in Rib-1,5-P2 and activation of phosphofructokinase 30 s after hypoxia [12].
  • Pertussis toxin (PTX), the phospholipase C (PLC) inhibitor U73122, the protein kinase C (PKC) inhibitor calphostin C, the Ca(2+)-dependent PKC inhibitor Gö 6976 and the phosphatidylinositol 3-kinase (PI 3-kinase) inhibitor LY294002 blocked the PE-mediated induction of the hsp70 gene promoter [13].
  • Furthermore, calphostin C did not block phenylephrine-induced situs inversus [14].
  • TNF-alpha secretion in response to both Nocardia fractions was inhibited by sphingosine, staurosporine and calphostin C, known PKC inhibitors, as well as by a PKC depletion procedure [15].
 

Biological context of Ucn 1028 C

 

Anatomical context of Ucn 1028 C

 

Associations of Ucn 1028 C with other chemical compounds

 

Gene context of Ucn 1028 C

 

Analytical, diagnostic and therapeutic context of Ucn 1028 C

References

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  28. Interleukin 10 is induced by recombinant HIV-1 Nef protein involving the calcium/calmodulin-dependent phosphodiesterase signal transduction pathway. Brigino, E., Haraguchi, S., Koutsonikolis, A., Cianciolo, G.J., Owens, U., Good, R.A., Day, N.K. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
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